cleavage site – Page 5 – Communicable Diseases Research

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

SARS-CoV-2 주요 프로테아제에 의한 다양한 바이러스 기질의 인식

Article

Published on 2021-09-102022-09-11
Journal: ACS Infectious Diseases [Category] Coronavirus, SARS, 치료제,

Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding †

Chemistry

Published on 2021-09-062022-10-31
Journal: Chemical Science [Category] COVID-19,

The structural basis of accelerated host cell entry by SARS-CoV-2†

SARS-CoV-2에 의한 가속화된 숙주 세포 진입의 구조적 기초†

Article

Published on 2021-09-012022-09-11
Journal: The Febs Journal [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] accelerate accelerated ACE-2 ACE2-RBD acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Antiviral strategies antiviral strategy base C-terminal domain causative agent cell entry cellular entry cleavage site conserved Contact contagious contribute coronavirus Coronavirus disease 2019 COVID-19 disease domain effective entry receptor enzyme epithelial epithelium exhibit explain faster Features flat furin furin protease HCoVs high-affinity binding host cell human coronavirus hypothese Interaction leads Mutation N-terminal domain notable NTD other proteases pandemic pandemic coronavirus Proteases Protein protein-protein interaction RBD receptor Receptor-binding domain respiratory respiratory epithelia S protein S1 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sialic acid sialic acid-binding domain. Spike protein subunit the receptor-binding domain the S protein the S1 subunit the spike protein Tight binding turn Viral viral RBD viral S viral spike
[DOI] 10.1111/febs.15651 PMC 바로가기 [Article Type] Article

Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19

계절 인간 코로나바이러스 OC43에 대한 면역은 COVID-19의 치명적인 악화를 완화합니다

Article

Published on 2021-08-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analysed antibody Antibody titre antibody titres cleavage cleavage site Clinical course Clinical data conserved coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 cross-reactive antibodies cross-reactive antibody cross-reactivity detect Deterioration develop disease Effect enzyme enzyme-linked immunosorbent assay epitope Epitopes fusion fusion peptide help human coronavirus human coronavirus OC43 Immunity immunogenic Immunosuppression Inpatient Inpatients investigated Mild mitigate not differ OC43 Outpatient outpatients patients with COVID-19 peptide peptides Pneumonia predict produced Prognosis respiratory S2ʹ cleavage site SARS-CoV-2 searched sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe cases Standard therapy titre with COVID-19
[DOI] 10.1016/j.ijid.2021.07.015 PMC 바로가기 [Article Type] Article

PNPLA3 and TLL-1 Polymorphisms as Potential Predictors of Disease Severity in Patients With COVID-19

Cell and Developmental Biology

Published on 2021-06-232022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] 95% CI absence ACE2 Admission Affect angiotensin-converting enzyme 2 binding characterized cleavage site Clinical course Comorbidity consecutive patient contribute Course COVID-19 death determinant disease course early phase Genetic polymorphism Genetic variant Genotype higher risk host cell host gene host receptor host’s cells IFNL3 immune stimulation in silico increased risk infect Infection Inflammation Intensive involved MERTK Mild nasopharyngeal swabs NLRP3 inflammasome nucleic acid older patient outcome pandemic Pathogenesis pathogenesis of COVID-19 pathway Patient PNPLA3 PNPLA3 I148M polymorphism Potential predicted Predictive Prognosis protease Protease activity Protein protein cleavage re-infect Reinfection risk SARS-CoV-2 SARS-COV-2 infection Severity of disease Sex significantly Specific spike subject subsequent Support the SARS-CoV-2 the Spike therapeutic approaches therapy tissue damage TLL-1 upregulation variant were assessed younger patient
[DOI] 10.3389/fcell.2021.627914 PMC 바로가기 [Article Type] Cell and Developmental Biology

Effect of clinical isolate or cleavage site mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell–cell fusion

Research Article

Published on 2021-06-202022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome addition Alter binding cath L, cathepsin L cathepsin L cell entry cell line cleavage cleavage site coronavirus CoV, coronavirus COVID-19 COVID-19, Coronavirus disease 2019 cytoplasmic tail DMEM, Dulbecco's modified Eagle's medium Effect EV, expression vector Evidence examined Factor FBS, fetal bovine serum furin cleavage site fusion protein hACE2, human ACE2 help host cell hpt, hours post transfection identify in viral internal fusion peptide investigated involved lung mammalian cell MEF, mouse embryonic fibroblast membrane fusion MERS, Middle East respiratory syndrome modulate Mutation offer pathogenic PBSN, PBS + 0.02% sodium azide processed protein cleavage protein stability Proteolytic processing residue responsible RIPA, radioimmunoprecipitation assay S trimer S, spike protein S1 and S2 S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2–infected patients SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Spike protein stability subunit the SARS-CoV-2 therapeutic target TMPRSS2, Transmembrane serine protease 2 transmembrane serine protease trimeric TTBS, Tris-buffered saline + Tween-20 variety viral entry Viral protein Virology virus entry while
[DOI] 10.1016/j.jbc.2021.100902 PMC 바로가기 [Article Type] Research Article

The COVID‐19 Menace

Review

Published on 2021-05-072022-10-31
Journal: Global Challenges [Category] COVID-19,

[키워드] acute respiratory syndrome Asymptomatic bind binding site Brain build caused cleavage site Comorbidities complications consequence Consequences contagious coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 determine disease disease spread drugs enzyme furin protease Health immune cells Immunity Infection Local moderate Mortality organs outbreak patients polybasic proteolytic receptors Research SARS‐CoV‐2 SARS‐CoV‐2 sequence severity Spike protein Spread Symptoms the disease tissue tropism transmembrane serine protease Transmission Vaccines Variability virus viruses widespread
[DOI] 10.1002/gch2.202100004 PMC 바로가기 [Article Type] Review

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Research

Published on 2021-04-272022-10-05
Journal: Nature Microbiology [Category] SARS, 치료제,

[키워드] Antiviral Cell cell line cleavage cleavage site cleaved Deletion epithelial cell epithelial cells expression ferret Frequency furin furin cleavage site growth IFITM impair insertion lentiviral Live virus lung lung cell membrane fusion mutant Patient polybasic postmortem tissue primary human airway protease TMPRSS2 Proteins pseudotype Replication required S1/S2 S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 sequence SARS-CoV-2 transmission SARS-CoV-2 virus selective spike glycoprotein Spike protein spike variant the SARS-CoV-2 titre Transmission transmitted Vero E6 virus entry wild-type virus
[DOI] 10.1038/s41564-021-00908-w [Article Type] Research

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

1,051명의 COVID-19 환자로부터 구성된 SARS-CoV-2 스파이크 단백질의 선형 에피토프 풍경

Article

Published on 2021-03-302022-09-12
Journal: Cell Reports [Category] SARS, 진단,

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

Research Article

Published on 2021-03-022022-10-29
Journal: mBio [Category] COVID-19, SARS,