conformational change – Page 5 – Communicable Diseases Research

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach

Research Article

Published on 2021-10-262022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

Distant residues modulate conformational opening in SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질의 구조적 개방을 조절하는 먼 잔류물

408

Published on 2021-10-262022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종,

[키워드] A570D ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all-atom molecular dynamics simulations Analysis antibody applied attachment binding conformational conformational change conserved contagious coronavirus correlation correlations COVID-19 D614G mutation Data analysis Distant drug drug design drug resistance effort Epidemics event focus Health crisis host cells hotspot identify implication independent independent component analysis Infection initiated involved membrane modulate molecular molecular biophysics molecular dynamics Molecular dynamics simulation monoclonal antibodies monoclonal antibody multiple coronaviruses mutant Mutation mutations new strain Novel coronavirus Outbreaks pandemic predicted Protein public health crisis RBD RBD region receptor Receptor-binding domain Region residue residues respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Significance Significant Spike protein Spike proteins statistical mechanics the RBD the receptor-binding domain the spike protein therapeutic Therapeutics Transmissibility treat Vaccine virulence virus structure
[DOI] 10.1073/pnas.2100943118 PMC 바로가기 [Article Type] 408

Generation of False-Positive SARS-CoV-2 Antigen Results with Testing Conditions outside Manufacturer Recommendations: A Scientific Approach to Pandemic Misinformation

Research Article

Published on 2021-10-202022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

[키워드] Abbott abrogated acute respiratory syndrome Ag-RDT Ag-RDTs antibodies antibody Antigen Anxiety buffer Care claimed clinical methods component condition conditions conducted conformational change coronavirus coronavirus disease country COVID-19 Critical demonstrated diagnostics Direct dissemination Epidemiology experiment extreme False positive False-positive False-positive results generate Generation Health help Interaction Laboratory mechanism media misinformation NaCl nonspecific occur offer PanBio Panbio assay pandemic positive control professionals proteinase public health Reactions recommendation recommendations reduce required resources Result resulting SARS-CoV-2 SARS-CoV-2 antigen shown specimen Support supported temperature tested Testing Treatment Tween 20 Virology while
[DOI] 10.1128/Spectrum.00683-21 PMC 바로가기 [Article Type] Research Article

GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2

GB-2가 ACE2와 야생형 사이의 상호작용을 차단하고 SARS-CoV-2의 스파이크 단백질 돌연변이

Article

Published on 2021-10-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, 변종, 진단, 치료제,

[키워드] (+)-Catechin (Pubchem CID: 9064) ACE2 B.1.351 Beta Beta variant binding can not catechin clinical study confirmed case conformational change coronavirus disease Coronavirus disease 2019 dose-dependent manner E484K E484K mutation Epsilon Epsilon variant flavin GB-2 Glycyrrhiza uralensis Health Organization induce Infection inhibit inhibited Interaction K417N L452R Lineage monoclonal antibodies multiple mutation multiple mutations Mutation N501Y Neutralizing activity Neutralizing antibodies neutralizing antibody outbreak Prophylaxis RBD Receptor binding domain reduced reported resistance to neutralizing antibodies SARS-CoV-2 SARS-CoV-2 variant single mutation spike Spike protein Temple the disease the RBD the spike protein theaflavin Theaflavin (Pubchem CID: 135403798) Theaflavin 3-gallate (Pubchem CID: 136825044). Tian Transmissibility variant variants wild type wild-type World Health Organization Wuhan Wuhan, China
[DOI] 10.1016/j.biopha.2021.112011 PMC 바로가기 [Article Type] Article

Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses

Article

Published on 2021-09-172022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection

Research Article

Published on 2021-09-172022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 Analysis Anti-SARS-CoV-2 Activity Anticoagulant anticoagulation aPTT, activated partial thromboplastin time AT, antithrombin binding BoSG, sulfated galactan from the red alga Botryocladia occidentalis characterized chondroitin composed computational simulation conformational change CS, chondroitin sulfate cytotoxic effects demonstrated DMEM, Dulbecco's modified Eagle medium domain DS, dermatan sulfate Effect FDA, US Food and Drug Administration FucCS, fucosylated chondroitin sulfate fucosylated chondroitin sulfate GAG, glycosaminoglycan GlcA, D-glucuronic acid glycan glycans HS, heparan sulfate HSQC, heteronuclear single quantum coherence IbFucCS, FucCS isolated from Isostichopus badionotus IbSF, I. badionotus-derived sulfated fucan Interaction kinetic LvSF, sulfated fucan from the sea urchin Lytechinus variegatus MD, molecular dynamics Molecular modeling mutant N501Y NMR nuclear magnetic resonance occur oligosaccharide Potential treatment PpFucCS, FucCS from the sea cucumber Pentacta pygmaea RBD RBD binding RBD, receptor-binding domain S-protein SA, streptavidin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SF, sulfated fucan SG, sulfated galactan SGP, spike glycoprotein SPR, surface plasmon resonance Structure sulfated surface plasmon resonance UFH, unfractionated heparin viral inhibition wildtype
[DOI] 10.1016/j.jbc.2021.101207 PMC 바로가기 [Article Type] Research Article

The SARS-CoV-2 spike protein is vulnerable to moderate electric fields

Article

Published on 2021-09-132022-10-04
Journal: Nature Communications [Category] SARS, 변종,

[키워드] ACE2 ACE2 receptor B.1.1.7 B.1.351 bind binding biochemical Brazil Cell change Computational biophysics conformational change COVID-19 develop docking exhibit help high affinity host cell host receptor IMPROVE In-vitro Infection prevention long-lasting magnitude MD simulation membrane protein moderate MOST mutant Mutation observé occur P.1 physical Physical sciences Prevent Probability Protein Proteins RBD RBM receptor Receptor binding domain receptor binding motif required responsible SARS-CoV-2 SARS-CoV-2 spike protein South Africa spike structural flexibility tested the RBD the S protein the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein therapy undergo Vaccine variants of concern viral infectivity virus virus entry VoC
[DOI] 10.1038/s41467-021-25478-7 PMC 바로가기 [Article Type] Article

Inactivation Activities of Ozonated Water, Slightly Acidic Electrolyzed Water and Ethanol against SARS-CoV-2

Communication

Published on 2021-09-082022-10-30
Journal: Molecules [Category] COVID-19, SARS,

The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

Review

Published on 2021-08-312022-10-28
Journal: Biology [Category] COVID-19,

[키워드] “cytokine storm” acidosis Anti-inflammatory approach Blood Blood pH Bohr effect Characteristics Clinical outcome conformational change consequence contribute Covid patients COVID-19 COVID-19 patients decrease Deterioration disease dysregulation early stage Effect effort form Gas exchange highlight homeostasis hypoxia immune system infections Inflammation involved Lactate lactic acid less lung mechanism oxygen saturation Pathogenesis pH positive protective antibodies Reactions resulting role S-protein SARS-CoV-2 saturation severe COVID-19 shown simple the disease therapy threshold value thrombosis tissues vicious cycle virus
[DOI] 10.3390/biology10090852 PMC 바로가기 [Article Type] Review

Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

Research Article

Published on 2021-08-312022-10-31
Journal: eLife [Category] COVID-19, MERS, SARS,

[키워드] absence acute respiratory syndrome Analysis Cell conformational conformational change conformations contagious control cell coronavirus COVID-19 Critical described endpoints energy landscapes fusion peptide glycan glycans glycosylation Host host cell induce Infection initial Invasion lack membrane membrane fusion pathogen post-translational modifications postfusion prefusion Protein provide regulate released remained reported reveal SARS-CoV-2 spike steric structural framework Structure the Spike transmembrane Transmission Vaccine viral genome viral particle virus was used while
[DOI] 10.7554/eLife.70362 PMC 바로가기 [Article Type] Research Article