In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5SARS-CoV-2 Omicron BA.1, BA.2 및 BA.5에 대한 치료 항체의 시험관 내 활성Article Published on 2022-07-232022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] active against Alter antibody cilgavimab D614G delta variant European Fold change growth less Lineage lineage B.1 monoclonal antibodies monoclonal antibody Mutation neutralising not enhanced omicron reduction replacement SARS-CoV-2 significantly Sotrovimab Spectrum spike glycoprotein strain therapeutic therapeutic antibodies Tixagevimab union variant of SARS-CoV-2 variants [DOI] 10.1038/s41598-022-16964-z PMC 바로가기 [Article Type] Article
Persistence of immunity and impact of third dose of inactivated COVID-19 vaccine against emerging variants면역의 지속성과 새로운 변이체에 대한 비활성화된 COVID-19 백신 3차 접종의 영향Clinical Trial Published on 2022-07-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] (alpha Alpha Antibody titers B cell memory Beta booster booster dose Breakthrough infection breakthrough infections Cell mediated immunity clinical concern Controlled trial COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Delta dose double-blind Effectiveness Heterologous homologous humoral humoral and cell mediated immunity Immunity immunogenicity inactivated India injection injection site itching magnitude neutralization titer Neutralizing antibodies neutralizing antibody omicron Pain persistence Phase 2 question Randomized controlled trial recipient redness registry responses Safe Serious Adverse Event Serious Adverse Events slight increase strain Trial registration vaccination variant variants VOCs within 6 months [DOI] 10.1038/s41598-022-16097-3 PMC 바로가기 [Article Type] Clinical Trial
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
The Impact of D614G Mutation of SARS-COV-2 on the Efficacy of Anti-viral Drugs: A Comparative Molecular Docking and Molecular Dynamics StudySARS-COV-2의 D614G 돌연변이가 항바이러스제의 효능에 미치는 영향: 분자 도킹 및 분자 역학 비교 연구Article Published on 2022-07-062022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] affected Analysis antiviral drug antiviral drugs binding affinities binding affinity Cell cell surface Characteristics Comparative Coronaviruses cytarabine D614G D614G variant docking method docking result docking results drug Dynamics evaluated exhibited Impact In-vitro Interaction molecular docking molecular dynamics Molecular dynamics simulation mutated Mutation parameter rate of infection receptor reliability reported ribavirin Spike protein the binding affinity the RBD the spike protein was performed [DOI] 10.1007/s00284-022-02921-6 PMC 바로가기 [Article Type] Article
Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant오미크론 변이체의 진화와 출현으로 이어지는 SARS-CoV-2의 돌연변이 캐스케이드Article Published on 2022-07-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Alpha Analysis cascade COVID-19 D614G Delta emergence events Evolution followed by Genome genomes GISAID H655Y Lambda majority Mutation mutations non-structural protein Non-synonymous Non-synonymous mutation NSP, non-structural protein nucleocapsid protein omicron Omicron variant ORF6 P681H performed Phylogeny RdRP rdrp, RNA dependent RNA polymerase. Repository RNA RNA dependent RNA polymerase RNA polymerase SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2, COVID-19, genome-wide, evolution, variants, VOC, VOI, VUM, SNP, mutation, non-synonymous, silent mutation, spike, RNA dependent RNA polymerase, NSP, UTR: Abbreviations: VOC, variant of co silent SNP specific clade Transmissibility untranslated region UTR UTR, untranslated region variant variant of SARS-CoV-2 variants variants of concern VoC VOI, variant of interest VUM, variant under monitoring while whole genome [DOI] 10.1016/j.virusres.2022.198765 PMC 바로가기 [Article Type] Article
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Alpha antagonist antagonists applied BA.1 Beta Caco2 cells Cathepsin-L cell entry cells cellular entry chlorpromazine Combination Compound D614G Delta drug Drug repurposing Drug screening Entry inhibitor FDA-approved drugs G protein G protein coupled receptor antagonist G-protein help highest identify Infection route inhibit inhibitors lentiviral Lentiviral vector lentiviral vectors mechanism membrane fusion omicron pathway phenothiazine preference pseudotyped pseudovirus pseudoviruses receptor receptor antagonist Receptor binding receptors respiratory responsible resulting SARS-CoV-2 several variant several variants Severe acute respiratory syndrome specific inhibitors spike variant synergistic targets TMPRSS2 variant variant of concern viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
Immunoinformatic paradigm predicts macrophage and T-cells epitope responses against globally conserved spike fragments of SARS CoV-2 for universal vaccination면역 정보 패러다임은 보편적 백신 접종을 위해 SARS CoV-2의 전 세계적으로 보존된 스파이크 단편에 대한 대식세포 및 T 세포 에피토프 반응을 예측합니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] allele antigenicity bioinformatics CD4+ CD4+ cells conserved country COVID-19 COVID-19 case COVID-19 cases D614G Delta develop Effect epitope Epitopes examined facilitated glycosylation H-bonding help highest HLA-DRB5 IC50 IEDB immunogenicity In silico mutation and antigenicity in some in-silico Inconclusive increase interactions introduced Macrophage MHC class MHC class and CD4+ cells MHC class II MHC-II mutant Mutation omicron predict Proteases reactivity receptors representation response responses against RMSD RMSD plot SARS CoV SARS CoV-2 SARS CoV-2 spike protein SARS-CoV-2 SARS-CoV-2 spike screened Screening sequence Spike protein stability SVMTriP T-cell Universal universal vaccination vaccination Vaccination strategy Vaccine variants Variation VaxiJen V2.0 [DOI] 10.1016/j.intimp.2022.108847 PMC 바로가기 [Article Type] Article
SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)Article Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant variants variants of concern variants of interest Variation viral infection virus VOCs VOIs [DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article
Reduced neutralizing antibody potency of COVID-19 convalescent vaccinated plasma against SARS-CoV-2 Omicron variantSARS-CoV-2 오미크론 변이체에 대한 COVID-19 회복기 백신 접종 혈장의 중화 항체 효능 감소Article Published on 2022-07-012022-09-11 Journal: Vox Sanguinis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-IgG Anti-S1 antibody assays B.1 best binding coefficient collected convalescent convalescent plasma correlated correlation coefficient COVID-19 D614G Donor fraction highest IgG IgG level Immunocompromised patient Immunocompromised patients Infection median Mutation NAb Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant plasma Quantitative reduced relationship resulting SARS-CoV-2 selected significantly lower Spearman Strains threshold titre titres vaccination variant [DOI] 10.1111/vox.13279 PMC 바로가기 [Article Type] Article
Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and IndiaB.1.1.7(알파) 및 B.1.617.2(델타)의 비교 유전체학, 진화 역학 및 RBD-hACE2 수용체 결합 패턴이 영국 및 인도의 대유행 반응과 관련됨Article Published on 2022-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed B.1.1.7 B.1.617.2 binding Cluster Comparative Comparative genomics COVID-19 infection Critical D614G Delta delta variant Epidemiology Evolutionary epidemiology Frequency genome sequence geographical distribution hACE2 help increase in India L452R MD simulation molecular Mutation mutations N501Y offer P681R pandemic performed phylogenetics plot Receptor binding reference strain Scatter plot scatter plots second second wave Spread stability submission Transmission variance Variance of UK and India. variant variants was performed Wuhan [DOI] 10.1016/j.meegid.2022.105282 PMC 바로가기 [Article Type] Article