Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome숙주 전사체의 통합 생물정보학 분석을 사용하여 COVID-19 병인 및 치료법에 대한 잠재적인 새로운 통찰력 식별Article Published on 2022-01-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis analyzed axon guidance Bioinformatics analysis clinical trials combating COVID-19 COVID-19 pathogenesis database DEGs differentially expressed gene Differentially expressed genes DNA drug drug candidate drug candidates Drug repurposing drug target dysfunction enrichment enrichment analysis entrectinib exacerbate Exemestane expressed fibrosis Functional module analysis gene expression profile help hidden host transcriptome Host transcriptome and drug repurposing hub genes hypercytokinemia identify identifying IMPROVE induce Interaction kinase kinases Lung fibrosis mechanism molecular mechanism molecular mechanisms omeprazole overexpression overlapping Pathogenesis pathogenesis of COVID-19 pathogenic pathway Pathway analysis Pathways performed PPI predicted protein-protein interaction Protein-protein interaction network selected Sema7A System Systems biology target targets TINF2 transcription factor transcription factors transcriptional profile transcriptional profiles Transcriptome Treatment was performed was used [DOI] 10.1016/j.ijbiomac.2021.11.124 PMC 바로가기 [Article Type] Article
Systems Biology and Bioinformatics approach to Identify blood based signatures molecules and drug targets of patient with COVID-19Research article Published on 2021-12-302022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, [키워드] acute respiratory syndrome approach association AURKB bioinformatics Biology Biomarker Biomarker signatures Blood blood cell Blood cells Blood common gene BUB1B CCNB1 Cell connection contagious Coronavirus-2 COVID-19 dataset DEGs diagnose differentially expressed gene Differentially expressed genes disease DLGAP5 drug target effective Gene Expression Gene ontology HJURP hub protein Identified identify infected with SARS-CoV-2 Infection KIF11 Microarray molecular MONITOR mononuclear cell NCAPG New coronavirus Ontology pathophysiology pathway patient with COVID-19 patients with COVID-19 PBMCs PBMCs cell performed Peripheral blood prevalence of COVID-19 progression Research SARS-CoV-2 signaling pathways subjects System therapeutic intervention TOP2A TPX2 transcript transcriptomic Treatment TTK with COVID-19 [DOI] 10.1016/j.imu.2021.100840 [Article Type] Research article
Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19인간의 다양한 암에서 TMPRSS2의 발현 및 임상 결과의 멀티오믹스: COVID-19의 잠재적 치료 표적Original Article Published on 2021-12-242022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, 바이오마커, [키워드] TMPRSS2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis bioinformatics Biomarker Blood Brain Breast Cancer cancer progression cancers clinical consequence clinical consequences Clinical outcome Colorectal cancer contribute coronavirus coronavirus disease correlated correlation COVID‐19 DEGs effective Evidence expressed gene expression Genes Genetic variations humans Immune cell infiltration immune infiltration incidence Infection lung molecular multi‐omics analysis network analysis outbreak ovarian Pathway analysis Pathways Patient potential therapeutic target Prevent Prognosis prognostic prognostic analysis Prognostic biomarkers Prognostic value progression Protein regulate respiratory Respiratory system SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus shown significantly Soft tissue therapeutic target tissue tissues TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumours [DOI] 10.1111/jcmm.17090 PMC 바로가기 [Article Type] Original Article
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
COVID-19 Transcriptomic Atlas: A Comprehensive Analysis of COVID-19 Related Transcriptomics DatasetsGenetics Published on 2021-12-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] anti-viral drug approach atlas bioinformatics Biomarker carried clinical setting clinical settings Comprehensive conditions confounding factor COVID-19 COVID-19 research database dataset datasets DEGs develop differentially expressed gene differentially expressed gene analysis disease severity explain expressed expressed gene Factor faster Gene Expression Gene Expression Omnibus generate GEO help human tissue identify increase in marker material molecular basis Molecular pathology omics analyses pathology Patient R software required Research retrieved SARS – CoV – 2 selected target the disease tissue transcriptomic transcriptomic data Vaccines [DOI] 10.3389/fgene.2021.755222 PMC 바로가기 [Article Type] Genetics
An integrative bioinformatics analysis for identifying hub genes associated with infection of lung samples in patients infected with SARS-CoV-2SARS-CoV-2에 감염된 환자의 폐 샘플 감염과 관련된 허브 유전자 식별을 위한 통합 생물정보학 분석Research Published on 2021-12-172022-09-11 Journal: European Journal of Medical Research [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach approaches Bioinformatics analysis biological processe biological processes BPS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set DDX58 DEGs differentially expressed gene Differentially expressed genes EGR1 function functions Gene ontology Genes genomes GO analysis GSE147507 Guidance Health Organization hub genes human body identify IFIH1 IFITM1 immune responses infected with SARS-CoV-2 Infection International Intersection ISG15 KEGG Kyoto lung OASL online tool pathophysiological mechanism Patient performed PHEIC PPI PPI network processed programming Protein–protein interaction Protein–protein interactions network public health emergency respiratory Result SAMD9 SAMD9L SARS-CoV-2 SARS-COV-2 infection screened selected severe acute respiratory syndrome Coronavirus severity STRING supplementary material TNFSF10 turn Viral viral infection WHO World Health Organization XAF1 [DOI] 10.1186/s40001-021-00609-4 PMC 바로가기 [Article Type] Research
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 InfectionCOVID-19의 유전자 발현 및 전사체 프로파일링 이해: SARS-CoV-2 감염에 대한 보호 면역 유전자 매핑을 위한 이니셔티브Immunology Published on 2021-12-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Against Agilent Analysis Arraystar CASC18 Characteristics Cluster cluster analysis co-expression COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset DEGs determine differentially expressed differentially expressed gene Differentially expressed genes disease pathogenesis DLEU2 element Gene Expression Genetic genetic factor GEO dataset globe GNAS healthy control healthy controls help identify immune immune response initiative inter-individual interactome mapping involved lncRNA mapping Microarray Mild molecular mechanism Pathway enrichment analysis performed Potential biomarker potential biomarkers PPI PPI network Profiling protective immunity protein-coding gene protein-coding genes protein-protein interaction Regulatory regulatory genes response responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient SNHG20 statistical TALAM1 three groups transcriptome profiling UICLM understanding Variability volunteers was used [DOI] 10.3389/fimmu.2021.724936 PMC 바로가기 [Article Type] Immunology
New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data다발성 골수종과 COVID-19 사이의 유전적 특성에 대한 새로운 통찰력: 유전자 발현 옴니버스 마이크로어레이와 암 게놈 아틀라스 데이터의 통합 생물정보학 분석Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] SARS, 유전자 메커니즘, [키워드] 95% CI association bioinformatics Bioinformatics analysis Cancer Characteristics Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cox regression analysis COX6C Cytochrome C cytochrome c oxidase data set DEGs differentially expressed gene Differentially expressed genes domain downregulated expression Factor Features FIVE Functional enrichment analysis Gene Expression Genetic Genome Hematological malignancy identify independent Infection Microarray Mild mild illness Multiple Multiple myeloma New NOD2 nucleotide oligomerization overall survival Patient performed Prognosis prognostic biomarker Prognostic biomarkers protein-protein interaction screened severe COVID-19 subunit survival upregulated with COVID-19 [DOI] 10.1111/ijlh.13717 PMC 바로가기 [Article Type] Comparative Study
Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorderResearch article Published on 2021-12-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, [키워드] Activation Affect Analysis approach biological processe blood gene expression Case report cause characterized coronavirus disease COVID-19 COVID-19 patient COVID-2019 dataset DEGs detect differentially expressed gene disease disorder downregulated dysregulated Genes Genetic immune induce involved mechanism molecular mechanism molecular pathways mononuclear cell Novel coronavirus Parkinson’s disorder pathway Pathways Patient PBMC Peripheral blood recent regulate RELA SARS-CoV-2 SP1 Symptom TP53 transcriptional regulators transcriptional signatures transcriptomic Treatment upregulated [DOI] 10.1016/j.sjbs.2021.07.074 [Article Type] Research article
Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study급성 폐 손상의 조절 및 COVID-19 및 종양 진행과의 연관성에 관여하는 핵심 유전자 : 생물 정보학 및 실험 연구Research Article Published on 2021-11-222022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute lung injury administration analysed anti-inflammatory agents Anti-inflammatory therapy association Atla bioinformatics Bioinformatics analysis cancers caused CCL2 changes in core correlation COVID-19 patient COVID-19 patients datasets DEGs Dexamethasone differentially expressed gene Differentially expressed genes down-regulation element expression functional annotation gene expression pattern gene expression patterns identify Ifi44 infectious involved LPS lung lung damage Lung inflammation lung inflammatory response Lung injury lung tissue marker mechanism mice Mmp8 molecular molecular markers molecular mechanism molecular mechanisms murine murine model neoplasia NODAL non-infectious overlap pathology Patient Plaur progression protein-protein interaction Ptx3 reconstruction Regulation regulatory network respiratory reversed RSAD2 Rtp4 Saa1 SARS-CoV-2 SARS-COV-2 infection SERPINE1 SOCS3 survival susceptible systemic inflammation text mining therapeutic target therapeutic targets Timp1 up-regulated were assessed whole-genome microarray with COVID-19 [DOI] 10.1371/journal.pone.0260450 PMC 바로가기 [Article Type] Research Article