Computational Determination of Potential Multiprotein Targeting Natural Compounds for Rational Drug Design Against SARS-COV-2Article Published on 2021-01-282022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Against Analysis anti-SARS-CoV-2 binding binding energy binding free energy Candidates caused complex complexes Compound COVID-19 COVID-19 pandemic Critical database demonstrated Determination docking docking result drug effective enzyme Enzymes glycyrrhizin imperative inhibit investigated MD simulation mechanism Molecular dynamics simulation MPD3 MPro multiprotein inhibiting natural compounds natural natural antiviral PLPro Potential receptor receptors reported residue RMSD SARS-CoV-2 SARS-COV-2 infection selected stability targeting trajectory van der Waal Virtual screening virus [DOI] 10.3390/molecules26030674 PMC 바로가기 [Article Type] Article
Computational Determination of Potential Inhibitors of SARS-CoV-2 Main ProteaseSARS-CoV-2 주요 프로테아제의 잠재적 억제제의 컴퓨터 결정Article Published on 2020-12-282022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 신약개발, 치료제, [키워드] affinity Alanine applied approach arise binding free energy caused Compound compounds Computational methods contribute darunavir database death decrease Determination determine docking drug effective drug effective drugs FIVE form free energy Glu166 H-bond H-bonds HIV-1 inhibiting inhibitor inhibitors inhibitors of SARS-CoV-2 Interaction leads Ligand molecular docking MPro Novel coronavirus Potential protease reported residue SARS-CoV-2 SARS-CoV-2 Mpro targets tested the disease treat van der Waal virus was used [DOI] 10.1021/acs.jcim.0c00491 PMC 바로가기 [Article Type] Article
Saliva NMR-Based Metabolomics in the War Against COVID-19COVID-19와의 전쟁에서 타액 NMR 기반 대사체학Article Published on 2020-12-152022-09-11 Journal: Analytical Chemistry [Category] SARS, 유전자 메커니즘, [키워드] ACE2 receptors Against approach Brazil changes in clinical phenotype COVID-19 described Determination disease disease course Disease progression effort epithelial cell epithelial cells explain help heterogeneous highlight longitudinal study mechanism metabolism metabolomic metabolomics noninvasive open oral mucosa pathophysiological pathophysiology pathway Pathways public health Saliva salivary salivary gland SARS-CoV-2 Scientific community situation the SARS-CoV-2 therapeutic virus [DOI] 10.1021/acs.analchem.0c04679 PMC 바로가기 [Article Type] Article
Navigating the Quagmire: Comparison and Interpretation of COVID-19 Vaccine Phase 1/2 Clinical TrialsReview Published on 2020-12-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse event adverse events antibody Antibody titers assays candidate clinical Clinical outcome clinical trials comparison COVID-19 Critical Determination Efficacy follow-up time harmonization highest immunogenicity methodological nine outcome outlined pandemic phase phase 3 trial Phase 3 trials profile Protective public health response robust SARS-CoV-2 Serious Adverse Event Study design the vaccine timepoint Vaccine Vaccines Variation [DOI] 10.3390/vaccines8040746 PMC 바로가기 [Article Type] Review
Animals and SARS‐CoV‐2: Species susceptibility and viral transmission in experimental and natural conditions, and the potential implications for community transmissionReview Published on 2020-11-042022-10-29 Journal: Transboundary and emerging diseases [Category] COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] activity acute respiratory syndrome animal Asymptomatic bat caused Clinical sign close contact community transmission companion animals conditions conducted coronavirus COVID‐19 COVID‐19 patients Critical demonstrated Determination determine disease transmission dog Epidemiology evaluate events Evidence experimental animals ferrets gastrointestinal disease global pandemic hamsters implication Infection investigated literature review Mild moderate MOST Naturally novel 2019 coronavirus one health pandemic positive Public health response Research SARS‐CoV‐2 SARS‐CoV‐2 infection Specy Surveillance susceptibility susceptible sustained the disease Transmission transmission studies understanding Viral transmission wildlife zoonoses zoonotic zoonotic disease zoonotic diseases [DOI] 10.1111/tbed.13885 PMC 바로가기 [Article Type] Review
Racial and Ethnic Disparities in COVID-19 Outcomes: Social Determination of HealthCommentary Published on 2020-11-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis black people Boston calculated center coronavirus disease COVID COVID-19 COVID-19 incidence COVID-19 pandemic death decrease Determination disadvantaged populations disparity distribution effective evaluate Factor Gender group Health imperative incidence intersectionality mitigate Mortality National Native occupational risk outcome pandemic poverty Quotient race Racial reported representation resource social determination of health survey The United States was performed [DOI] 10.3390/ijerph17218115 PMC 바로가기 [Article Type] Commentary
Determination of an optimal control strategy for vaccine administration in COVID-19 pandemic treatmentResearch article Published on 2020-11-012022-10-05 Journal: Computer methods and programs in biomedicine [Category] SARS, 치료법, [키워드] Algorithms Analysis biological systems carried China compartmental model Concentration COVID-19 COVID-19 pandemic defined Determination determine Differential evolution algorithm Diseases Effect Epidemic essential element Inclusion infected individual information Inverse problem mathematical Mathematical modeling of COVID-19 Multi-objective optimization novel coronavirus disease Optimal control problem optimization parameter parameters physical predict problem Result subject the epidemic to define Treatment vaccination Vaccine vaccine administration [DOI] 10.1016/j.cmpb.2020.105664 [Article Type] Research article
Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort studyResearch Published on 2020-10-212022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] alteration Anemia C-reactive protein Chest computed tomography clinical examination cohort study computed tomography scan coronavirus disease correlation Course COVID-19 Critical cytokine deficiency demonstrated Determination disease onset evaluated ferritin first COVID-19 symptom hepcidin hospital Hyperferritinemia hyperinflammation increased mortality individual Inflammation inflammation marker interleukin-6 investigated iron homeostasis Iron metabolism Laboratory testing Lung pathology majority Mild MONITOR mononuclear cell mRNA expression multicentre parameter participant Patient patients performance status Peripheral blood physical prospective observational cohort Result SARS-CoV-2 serum severe lung pathology significantly Still subject survived Treatment [DOI] 10.1186/s12931-020-01546-2 PMC 바로가기 [Article Type] Research
Rapid Determination of SARS-CoV-2 antibodies using a bedside, point-of-Care, serological testResearch Article Published on 2020-10-072022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] Bedside chest imaging complementary COVID COVID-19 death Determination Diagnosis diagnostic diagnostics discharge General population high accuracy IgG IgM IgM/IgG immunological infected patients information material MONITOR negative onset of symptom onset of symptoms pandemic Patient patients hospitalized positive Practitioner Rapid Rapid test remained RT–PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivity sera Seroconversion Serological assay serological test serology Social distancing measure specificity subsequent symptom onset tested the SARS-CoV-2 value Ventilation [DOI] 10.1080/22221751.2020.1826892 PMC 바로가기 [Article Type] Research Article
Patient characteristics and admitting vital signs associated with coronavirus disease 2019 (COVID-19)–related mortality among patients admitted with noncritical illness심각하지 않은 질병으로 입원한 환자 중 코로나바이러스 질병 2019(COVID-19) 관련 사망률과 관련된 환자 특성 및 인정하는 활력 징후Original Article Published on 2020-09-152022-09-12 Journal: Infection Control and Hospital Epidemiology [Category] MERS, 진단, [키워드] 95% CI Admission Admitted Patient age Analysis Care Characteristics characterized collected Community Comorbidities Comorbidity coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill Decreased demographic characteristics Determination determine diabete diabetes discharge epidemiologists Factor help hospital Logistic regression mechanical ventilation Mortality MOST oxygen oxygen saturation Patient patient age patient data patients positive recorded Retrospective analysis risk factor Risk factors routine care System The United States United States vital sign vital signs [DOI] 10.1017/ice.2020.461 PMC 바로가기 [Article Type] Original Article