downregulated – Page 5 – Communicable Diseases Research

Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different Severities

Immunology

Published on 2022-01-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling Pathways

COVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석

Research Article

Published on 2021-12-242022-09-10
Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization
[DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article

Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome

세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행

Immunology

Published on 2021-12-092022-08-31
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] ACE2 expression activated adjusted alveolar cell among others Analysis analyzed ARDS ARDS patients bind Biomarker Biomarkers carrier carriers Cell cell-free microRNAs cell-to-cell communication cells circulating community acquired pneumonia controls Corona COVID-19 COVID-19 ARDS patient COVID-19 pneumonia CXCL8 Differential gene expression differential gene expression analysis differentially expressed miRNA downregulated epithelial evaluated EVs Extracellular vesicles function group healthy control healthy controls IL6 increase Inflammatory inhibited interleukin interleukin-6 interleukin-8 investigated let-7e-5p log2FC lung Lung diseases mechanically ventilated patient mediators miR-146 miR-146a-5p miRNA miRNAs mRNA mRNA transcript mRNA transcripts nasal epithelium network network analysis neutrophil neutrophil recruitment olfactory OR52N2 pathophysiology Pathways Pneumonia Precipitation prospectively studied receptor regulate regulated respiratory Result resulting RNA sequencing SARS-CoV-2 spike protein secrete Sepsis Severe Acute Respiratory Corona Virus-2 Syndrome severe COVID-19 Signaling signaling pathway significantly small RNA small RNA sequencing Spike protein symptomatic patient syndrome the healthy therapeutic targets TLR4 Toll-like receptor toll-like receptor 4 total RNA transcript upregulated Vesicle with COVID-19
[DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology

Early Response of CD8+ T Cells in COVID-19 Patients

Article

Published on 2021-12-032022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

[키워드] apoptotic CD3+ CD8 CD8+ CD8+ T cell CD8+ T cells Cell COVID-19 COVID-19 patient cytokine disease disease course downregulated effector memory FASL faster form Frequency gene expression pattern gene expression profile GNLY granulysin granzyme B granzymes GzmA GzmB GZMK healthy control healthy controls IFN-γ IFN-γ immune response interferon-γ investigated lack Ligand lymphocyte Mild Mild symptom moderate mRNA expression nine Patient perforin Peripheral blood predictor PRF1 progressed progression proportion Protein response SARS-COV-2 infection SARS-CoV2 significantly subpopulation the disease
[DOI] 10.3390/jpm11121291 PMC 바로가기 [Article Type] Article

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.

Article

Published on 2021-12-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data

다발성 골수종과 COVID-19 사이의 유전적 특성에 대한 새로운 통찰력: 유전자 발현 옴니버스 마이크로어레이와 암 게놈 아틀라스 데이터의 통합 생물정보학 분석

Comparative Study

Published on 2021-12-012022-09-11
Journal: International journal of laboratory hematology [Category] SARS, 유전자 메커니즘,

[키워드] 95% CI association bioinformatics Bioinformatics analysis Cancer Characteristics Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cox regression analysis COX6C Cytochrome C cytochrome c oxidase data set DEGs differentially expressed gene Differentially expressed genes domain downregulated expression Factor Features FIVE Functional enrichment analysis Gene Expression Genetic Genome Hematological malignancy identify independent Infection Microarray Mild mild illness Multiple Multiple myeloma New NOD2 nucleotide oligomerization overall survival Patient performed Prognosis prognostic biomarker Prognostic biomarkers protein-protein interaction screened severe COVID-19 subunit survival upregulated with COVID-19
[DOI] 10.1111/ijlh.13717 PMC 바로가기 [Article Type] Comparative Study

Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

Research article

Published on 2021-12-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘,

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome

무증상 코비드 -19 감염에서 상향 조절 된 유형 I 인터페론 반응은 개선 된 임상 결과와 관련이 있습니다.

Article

Published on 2021-11-252022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 치료법, 치료제,

[키워드] Antigen presentation approach Asymptomatic Asymptomatic cases Asymptomatic COVID-19 Biomarker Biomarkers blood transcriptome CD177 Clinical outcome Computational biology and bioinformatics COVID-19 COVID-19 case COVID-19 disease disease Disease progression downregulated downregulation dysregulation early response early stage effectively controlled help Host humoral ICAM3 IFN IFNAR2 immunology IMPROVE Infection Inflammatory initial interferon interferons IRF2BP1 IRF2BP2 IRF2BPL IRF4 ISG ISGs limit marker MAVS Microbiology Mild mRNA translation neutrophil pathway Pathways progressive disease protective mechanism protective mechanisms response SAMHD1 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity of COVID-19 significantly SOCS3 stimulated suppression symptomatic disease These data TLR8 Transcriptome Treatment type I interferon type I interferons understanding uninfected upregulated upregulation Viral
[DOI] 10.1038/s41598-021-02489-4 PMC 바로가기 [Article Type] Article

ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

ACE2-유사 카르복시펩티다제 B38-CAP는 SARS-CoV-2로 유발된 폐 손상으로부터 보호합니다

Article

Published on 2021-11-232022-09-12
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 expression acting acute lung injury alleviate angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models carboxypeptidase cardiovascular disease cell entry COVID-19 patients decoy degrade downregulate downregulated edema Elevation endogenous enzymatic activity enzyme Evidence human ACE2 IMPROVE in vivo Infection inhibit inhibit SARS-CoV-2 lung lung edema Lung injury Lung pathology Lungs not neutralize Pathologies pathology peptides PROTECT Protective Protein receptor recombinant Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters significantly soluble ACE2 spike Symptom therapeutic strategy transgenic mice Treatment virus
[DOI] 10.1038/s41467-021-27097-8 PMC 바로가기 [Article Type] Article

Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis

차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견

Case Study

Published on 2021-11-172022-09-01
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome
[DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study