ENCODE – Page 5 – Communicable Diseases Research

The glycosylation in SARS-CoV-2 and its receptor ACE2

SARS-CoV-2 및 그 수용체 ACE2의 글리코실화

Review

Published on 2021-11-152022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 치료기술, 치료제,

SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems

SARS-CoV-2는 보체 및 키닌 시스템의 활성화를 통해 COVID-19 병리를 악화시킵니다

Immunology

Published on 2021-11-052022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법,

[키워드] activate Activation acute respiratory syndrome best binding blockade bradykinin C1q classical pathway complement complement system contribute COVID-19 Efficiency ELISA ENCODE generate Genome globular head Human plasma include inflammatory pathway Kallikrein Kallikrein-kinin system Kinin kinin-kallikrein system membrane molecular weight multi-organ failure normal human plasma nucleocapsid peptide peptides platform post COVID “long-haulers” Protein receptor Recombinant protein respiratory SARS-CoV-2 Severe acute respiratory syndrome solid phase SPR structural protein structural proteins surface plasmon resonance System the SARS-CoV-2 therapeutic Treatment treatment of COVID-19 Trigger triggers turn Vasoactive Viral viral particle
[DOI] 10.3389/fimmu.2021.767347 PMC 바로가기 [Article Type] Immunology

Neural connectome prospectively encodes the risk of post-traumatic stress disorder (PTSD) symptom during the COVID-19 pandemic

Research article

Published on 2021-11-012022-10-05
Journal: Neurobiology of Stress [Category] 유전자 메커니즘,

GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism

GDF15: 철 대사와 관련된 COVID-19의 면역 조절제 및 전략

Review

Published on 2021-11-012022-09-11
Journal: Trends in endocrinology and metabolism: TEM [Category] Coronavirus, SARS, 바이오마커, 신약개발, 치료법,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus alteration angiotensin appear association attachment cardiovascular diseases caused contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Cytokine storm death domain drug therapy ENCODE endothelial envelope enzyme expressed GDF15 growth host cell host cells Immunity increases in iron iron homeostasis Iron metabolism life cycle mediator membrane metabolism multiorgan failure nucleocapsid outcome pandemic Patient patients with COVID-19 progression of disease Proteins provide Receptor-binding domain respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural protein structural proteins subunit syndrome target TGF-β therapeutic therapy tissue tissue damage Tolerance transforming growth factor vascular dysfunction virus Virus life cycle with COVID-19
[DOI] 10.1016/j.tem.2021.08.011 PMC 바로가기 [Article Type] Review

Effect of SARS-CoV-2 proteins on vascular permeability

Research Article

Published on 2021-10-252022-10-31
Journal: eLife [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Affect affected Analysis applied catalytic CD31 characterized cloned Coagulation complications coronavirus disease COVID-19 Cytokine storm dead detrimental Effect Effects ENCODE endothelial endothelial cells Endothelial dysfunction Endothelium expressed expression Human human cell identify IL-6 Infection lung damage Manifestations mutant NSP2 organs other tissue overexpression PPI PPI network predicted Protein protein interactions Protein–protein interaction Proteins reduced SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein severe disease significant changes in the disease the SARS-CoV-2 Vascular vascular dysfunction vascular permeability vasculature Viral protein von Willebrand factor while ZO-1 β-catenin
[DOI] 10.7554/eLife.69314 PMC 바로가기 [Article Type] Research Article

Structure-Based Primer Design Minimizes the Risk of PCR Failure Caused by SARS-CoV-2 Mutations

SARS-CoV-2 돌연변이로 인한 PCR 실패 위험을 최소화하는 구조 기반 프라이머 설계

Cellular and Infection Microbiology

Published on 2021-10-252022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 치료기술, 치료법, 치료제,

[키워드] 3′ end addition Affect Amino acid amino acid residue caused codon coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 test effective ENCODE evade failure false-negative golden standard Health less Mutation N protein nucleic acid nucleic acid sequence nucleocapsid nucleotide nucleotides occur pair PCR primer Primers principle Protein qPCR test Qualitative quantitative reverse-transcription PCR resulting reverse transcription-PCR RT-qPCR RT-qPCR test SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence significantly the SARS-CoV-2 thermal stability Tryptophan Vaccine variant variants
[DOI] 10.3389/fcimb.2021.741147 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Search for RNA aptamers against non-structural protein of SARS-CoV-2: Design using molecular dynamics approach

Research

Published on 2021-10-122022-10-28
Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19,

Emerging Mutations in Nsp1 of SARS-CoV-2 and Their Effect on the Structural Stability

Article

Published on 2021-10-062022-10-28
Journal: Pathogens [Category] COVID-19,

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

광범위하게 지시된 SARS-CoV-2-특이적 CD4+ T 세포 반응에는 급성 및 소실된 COVID-19 환자의 막 및 핵단백질 내에서 자주 검출되는 펩티드 특이성이 포함됩니다.

Research Article

Published on 2021-09-162022-09-10
Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법, 치료제,

[키워드] assays Author average binding affinity breadth CD4+ T cell Cohort cohort of patient COVID-19 cytokine data set defined dominant elicited ELISPOT ENCODE enzyme epitope Epitopes Ex vivo examined FIVE Frequency HLA HLA binding HLA class II ICS IFN-γ immune response immune responses immunological Immunopathogenesis in vitro include individual individual immune response interferon interferon-γ intracellular cytokine staining M protein membrane MHC class N protein novel nucleoprotein one patient overlapping Patient patients peptide peptides phenotype Protein resolved response response frequency SARS-CoV-2 envelope SARS-CoV-2 genome SARS-COV-2 infection screened Specificities specificity Spike protein structural protein structural proteins subsequent T cell T cell epitope T cell response T cell responses T cells tetramer the N protein the SARS-CoV-2 the spike protein to define Vaccine design Viral Viral proteins vitro cultivation
[DOI] 10.1371/journal.ppat.1009842 PMC 바로가기 [Article Type] Research Article

Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study

SARS-CoV-2 측방유동항원 검사의 비교 성능 및 임상 검체에서 감염성 바이러스 검출과의 연관성: 단일 센터 실험실 평가 연구

Articles

Published on 2021-09-012022-09-10
Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 치료기술, 치료제,

[키워드] alternative technology Analysis Antigen association B.1.1.7 B.1.1.7 variant be positive cassette clinical sample clinical samples collected Community Comparative comparison Comprehensive copy number cornerstone correlation COVID-19 Ct value Ct values Culture Department Device diagnostic diagnostic test disease severities dominant ENCODE evaluated except for family finding FIVE Fluorescence foundation funding Genotype greater group head Head-to-head comparison health-care help highest household contacts identify implementation infected individual infected individuals infectious sample Infectious virus Inpatient Inpatients King Laboratory Lateral lateral flow LFD limit of detection limitation London Longitudinal studies longitudinal study Medical Research Council naso-oropharyngeal swab not affected Outpatient outpatients PCR PCR cycle PCR testing PFUs plaque-forming unit positive Quantitative quantitative culture question raised ranged Rapid Rapid test real-time RT-PCR reduced RNA RT-rtPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 testing selected sensitivities sensitivity Specificities specificity spring St Thomas' Hospital Support Surescreen Swab swabs Test test result tested Thoma threshold UK variant B.1.1.7 understanding Vero E6 VERO E6 cells Viral viral culture viral growth Viral RNA virus virus culture virus infectivity Wellcome Trust were assessed were used whole-genome sequencing
[DOI] 10.1016/S2666-5247(21)00143-9 PMC 바로가기 [Article Type] Articles