epithelial cell – Page 5 – Communicable Diseases Research

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Enoxaparin은 COVID-19에 대한 유망한 약물 조합인 TMPRSS2의 알파-1-항트립신 억제를 증가시킵니다.

Article

Published on 2022-03-252022-09-11
Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법,

Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammation

COVID-19 관련 급성 호흡 곤란 증후군(ARDS) 및 전신 염증에 대한 새로운 치료 희망으로서의 인간 태반 유래 양막 상피 세포

Review

Published on 2022-03-252022-09-11
Journal: Stem Cell Research & Therapy [Category] SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus aldosterone alveolar fluid clearance amniotic Amniotic membrane angiotensin ARDS cause Cell complications complications of COVID-19 consequence Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged death drug delivery system Efficacy epithelial cell epithelial cells Epithelial stem cells Exosome Exosomes feature fibrosis hAEC Human immune system immunomodulation immunomodulatory effect immunomodulatory effects mechanism membrane multi-organ failure organ organs Prevent question reaction reduce regeneration regenerative medicine Regulation Renin renin-angiotensin-aldosterone system respiratory distress SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stem cells suggested syndrome systemic inflammation therapeutic Therapeutic approach therapeutic option These cells thrombotic Thrombotic events viral variant
[DOI] 10.1186/s13287-022-02794-3 PMC 바로가기 [Article Type] Review

The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3

SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성

Article

Published on 2022-03-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종,

[키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses
[DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article

Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder

COVID-19 모델로 Zebrafish 유충 탐색: 수영 방광에서 SARS-CoV-2 복제 중단 가능성

Article

Published on 2022-03-112022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술,

Exploration of the ocular surface infection by SARS-CoV-2 and implications for corneal donation: An ex vivo study

SARS-COV-2에 의한 안구 표면 감염의 탐색 및 각막 기증에 대한 시사점 : 생체 외 연구

Research Article

Published on 2022-03-012022-09-10
Journal: PLoS Medicine [Category] MERS, SARS, 치료기술,

[키워드] 24 hour 24 hours ACE-2 acute respiratory syndrome aims Algorithms angiotensin angiotensin-converting enzyme 2 bulbar conjunctiva cathepsin cellular entry Conjunctiva Contamination contraindication contraindications Cornea Corneal Corneal Graft Corneal transplantation coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis Ct value Culture culture media decrease diagnosed diagnosed with COVID-19 Donor Donor selection donors enzyme epithelial cell epithelial cells epithelium evaluate Evidence Ex vivo exacerbated exploration expresse expressed expression expression of SARS-CoV-2 expression pattern female genetic material healthy donor immunohistochemistry implication IMPROVE increase in Infection infectious dose inoculation involved lack limbus limited sample size mandatory media median moderate molecular mRNA level nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Not contaminated Ocular surface organ organ culture pandemic pathway Patient PCR positive Positive test Postinfection promote promoted Protein qPCR quantified quantitative PCR question RdRP receptor Replication researcher respiratory respond retrieved reverse transcription Reverse transcription quantitative PCR risk risk of transmission RNA RNA copy RNA sequence RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase Support TCID tested tissue tissue culture tissues TMPRSS2 Transmission utility Viral Viral detection Viral RNA was tested were infected worsened
[DOI] 10.1371/journal.pmed.1003922 PMC 바로가기 [Article Type] Research Article

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

ORF3a에 의해 암호화된 SARS-CoV-2 비로포린은 NLRP3 염증 경로를 유발합니다

Article

Published on 2022-03-012022-09-11
Journal: Virology [Category] SARS, 변종, 치료제,

Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다

Article

Published on 2022-03-012022-09-11
Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제,

[키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition
[DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Induces Cytokine Responses in Human Basophils

SARS-CoV-2는 인간 호염기구에서 사이토카인 반응을 유도합니다

Article

Published on 2022-02-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19

Research

Published on 2022-02-172022-10-31
Journal: Genome Medicine [Category] COVID-19, MERS,

[키워드] ABO airways alteration association calculate CCR1 CD8+ T cell CD8+T cell Cell cell types Cell-mediated immunity cells chemotaxis collected contribute Control COVID-19 COVID-19 infection COVID-19 pandemic CXCR6 cytokine detrimental disease severity dysregulated immune response Effect effective vaccine elevated epithelial cell expressed expressed gene expression facilitate Factor feature functional Genes Genetic genetic architecture genetic determinant GWAS GWAS summary statistics healthy control higher risk Host host genetics IFITM1 Immune cell immune cells immune response Immunity immunological increase in independent Inflammatory Inflammatory cytokines inflammatory storm Interaction involved lung tissues memory Migration Mild moderate mononuclear cell notable Patient PBMC Peripheral blood progression proliferation provide recruitment Result reveal risk S100A12 S100A8 S100A9 scRNA-seq dataset sequencing data severe COVID-19 Severe infection Severe patient severe patients severity of COVID-19 significantly single-cell single-cell sequencing subpopulation subset subtype supplementary material Symptom T cell understanding up-regulated
[DOI] 10.1186/s13073-022-01021-1 PMC 바로가기 [Article Type] Research