Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers고도로 노출되었지만 감염되지 않은 의료 종사자 사이에서 SARS-CoV-2에 대한 감수성에서 ACE2 유전적 다형성의 역할Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] A allele ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 COVID-19 COVID-19 patients drug target evaluate Evaluating Genetic Genetic polymorphism Genetic variant genetic variants healthcare worker help hospitalized patient identify increased risk individual polymorphism role SARS-CoV-2 SARS-COV-2 infection selected single-nucleotide single-nucleotide polymorphism SNP susceptibility susceptible T allele uninfected variant with COVID-19 [DOI] 10.1080/22221751.2021.1902755 PMC 바로가기 [Article Type] Article
Virologic Features of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in ChildrenArticle Published on 2021-12-012022-11-16 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome age analyzed Asymptomatic children children with COVID-19 collected Community coronavirus coronavirus 2 coronavirus disease COVID-19 creating Critical Cytopathic effect data-driven disease severity Evolution genetic variants Guidance median age mitigate observation Older pandemic pediatric pediatric COVID-19 polymerase chain populations public health quantified respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence SARS-CoV-2 viral load severe disease social distancing Swab symptom duration Transmission Vaccination strategy Vaccine variant viral culture viral dynamics viral loads whole genome sequence [DOI] 10.1093/infdis/jiab509 PMC 바로가기
The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19Covid-19로 인한 사이토 카인 폭풍의 치료를위한 중간 엽 줄기 세포의 잠재력Review Published on 2021-11-262022-09-10 Journal: BioMed Research International [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected approved caused circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient droplet transmission Effect genetic variants Gingiva healing immune disorder immune responses immune systems mechanism mesenchymal stem cell Mesenchymal stem cells MSCs multiple organ failure oral cavity outbreak Potential public health regulate respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus stability STEM stem cells storm syndrome therapeutic activity tissue Transmission treatment for COVID-19 variants of SARS-CoV-2 [DOI] 10.1155/2021/3178796 PMC 바로가기 [Article Type] Review
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its first variants in fourplex real-time quantitative reverse transcription-PCR assaysResearch Report Published on 2021-11-252022-10-30 Journal: Microbial Cell [Category] COVID-19, [키워드] 229E acute respiratory syndrome amplification amplify approach B2M circulating circulating variant clinical sample coding sequence contagious coronavirus COVID-19 detection dominant early diagnosis Efficacy envelope evaluated exhibited False-positive Genes genetic variants human coronavirus identify Infection Internal control linear locked nucleic acid (LNA) molecular diagnostics mutant Mutation nine NL63 nucleic acid nucleotide OC43 pandemic Patient populations positive Prevent primer-probe set probe quantified Quantitative real-time TaqMan reverse transcription PCR assays required Respiratory pathogens Result reverse transcription PCR reverse transcription-PCR RNA transcripts rRT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral RNA selective sequence spike Spread TaqMan the Spike transmission of SARS-CoV-2 variant viral strain virus wild-type [DOI] 10.15698/mic2022.01.767 PMC 바로가기 [Article Type] Research Report
Survey of SARS-CoV-2 genetic diversity in two major Brazilian cities using a fast and affordable Sanger sequencing strategy빠르고 저렴한 Sanger 염기서열분석 전략을 사용하여 브라질의 두 주요 도시에서 SARS-CoV-2 유전적 다양성 조사Article Published on 2021-11-012022-09-11 Journal: Genomics [Category] SARS, 변종, 치료기술, [키워드] amplify approach China circulating detect diagnostic procedures disease severity dissemination dominant followed by fragment fragment of genetic diversity genetic variants genetic variants. immunodeficiency less management measles virus P.2 variant Patient Patient management primer Primers Protein Rapid Sanger sequencing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein Spread survey the SARS-CoV-2 genome the Spike transmission rates Vaccine variant variants variants of SARS-CoV-2 virus virus genotypes [DOI] 10.1016/j.ygeno.2021.10.015 PMC 바로가기 [Article Type] Article
IFNL4 genetic variant can predispose to COVID-19IFNL4 유전자 변이체는 Covid-19를 유리하게 할 수 있습니다Article Published on 2021-10-272022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] 95% CI age allele antiviral activity caused clearance confirmation contribute Control Coronaviruses COVID-19 COVID-19 patient disease disease severity General population Genetic association study Genetic variant genetic variants Genotype IFNL4 Infectious disease Infectious diseases Interferon lambda investigated mechanism not affected other infectious diseases overexpressed patients with COVID-19 polymorphism Predictive risk factor RNA viruses SARS-CoV-2 SARS-COV-2 infection Sex shown significantly lower T allele viral infection with COVID-19 [DOI] 10.1038/s41598-021-00747-z PMC 바로가기 [Article Type] Article
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severityCOVID-19 질병 심각도의 위험 바이오 마커로서 비타민 D- 관련 다형성 및 비타민 D 수준Multicenter Study Published on 2021-10-212022-09-01 Journal: Scientific Reports [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료법, [키워드] activating adaptive Admission AMDHD1 analysed association binding Biomarker characterized Concentration correlation COVID-19 disease severity COVID-19 patients COVID-19 severity CYP24A1 CYP2R1 deficiency DHCR7 disease severity enrolled European population explain genetic background genetic susceptibility genetic variants hospital hospitals Host Immunity Immunogenetics infected with SARS-CoV-2 Infection innate and adaptive immunity outcome Pathways Patient polymorphism Polymorphisms Predictive markers Prevalence Protein Research risk Risk factors SEC23A serum severity survival Trial registration variant variants VDR Viral diseases viral infection Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D pathway was measured [DOI] 10.1038/s41598-021-99952-z PMC 바로가기 [Article Type] Multicenter Study
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE ResidentsUAE 거주자 사이의 비타민 D 대사 경로의 유전적 변이와 COVID-19의 심각성 간의 연관성Article Published on 2021-10-202022-09-10 Journal: Nutrients [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] 25-hydroxyvitamin D affected association Cell COVID-19 COVID-19 severity Critical CYP2R1 deficiency Effect Factor genetic determinant genetic determinants genetic variants Genetic variation Genetic variations genotype data genotypes hospital Human immune system implicated Infection investigated involved mechanism mechanism of action metabolism NADSYN1 outcomes Patient patients with SARS-CoV-2 polymorphism Population potential risk Research resident SARS-CoV-2 SARS-COV-2 infection serum serum 25-hydroxyvitamin D severe COVID-19 severity of COVID-19 single-nucleotide Single-nucleotide polymorphisms Spread two groups UAE United Arab Emirate United Arab Emirates vaccination variant VDR Viral viral infection Vitamin D vitamin D deficiency Vitamin D Metabolism Vitamin D status [DOI] 10.3390/nu13113680 PMC 바로가기 [Article Type] Article
Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR유연한 CFDR을 사용하여 GWAS 발견을 향상시키기 위해 임의의 분포에서 보조 데이터 활용Research Article Published on 2021-10-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach association associations Asthma auxiliary boost can be used category complex complex diseases Conditioning Control correlation covariate detect distribution distributions error rate Evidence evidence of experiments extension false discovery rate FDR functional Genetic genetic association genetic associations Genetic variant genetic variants Genome-wide association studies genomic genomic data genomic region GWAS Human genome identify implementation IMPROVE increase independent Interpretation iterations motivation not significant P -value Pleiotropy power provide Region required resource robust Sample size sensitivity SNP SNPs Statistical power Support Test statistics threshold traits UK Biobank data while [DOI] 10.1371/journal.pgen.1009853 PMC 바로가기 [Article Type] Research Article
Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report전격성 H1N1 및 중증급성호흡기증후군 코로나바이러스-2 감염, 4년 간격으로 뚜렷한 근본 원인 없이: 증례 보고Case Reports Published on 2021-10-082022-09-10 Journal: Journal of Medical Case Reports [Category] MERS, SARS, 변종, 신종인플루엔자, [키워드] acute kidney acute respiratory syndrome Admission age Analysis Antiviral asymptomatic infection autoantibody Case report challenge clinical picture clinical recovery Comorbidity contributing to Coronavirus-2 Course COVID-19 demonstrated disease disease-causing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Exome expression Factor fulminant genetic change Genetic changes genetic defect genetic defects Genetic variant genetic variants H1N1 H1N1 influenza healthy ICU immune immunological impairment indicate Infection infections Influenza intensive care intensive care unit admission interferon Interferon (INF) interferon pathway interferon response interferon-stimulated gene mechanical ventilation mononuclear cell mononuclear cells Pathways Patient Peripheral blood Perturbation reduced respiratory risk factor Risk factors SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity suffered susceptibility the interferon the patient triggered type I Variation Viral viral infection viral infections virus infection [DOI] 10.1186/s13256-021-03113-9 PMC 바로가기 [Article Type] Case Reports