Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19Research article Published on 2022-05-012022-10-05 Journal: Clinical neurophysiology : official journal of the [Category] 바이오마커, 유전자 메커니즘, [키워드] abnormality Cohort collected Comorbidities COVID-19 COVID-19 pandemic COVID-19 patient Critical died discharge EEG electroencephalogram Electroencephalography epileptiform Factor Hemorrhagic Stroke hospital hospitalized COVID-19 patient hospitalized COVID-19 patients increasing age indication Injury MOST NeuroCOVID New York City nonspecific objective occurred outcome Patient patients patients with COVID-19 performed Result retrospective Risk factors Seizure Seizures severe COVID-19 Significance stroke Treatment [DOI] 10.1016/j.clinph.2022.03.001 [Article Type] Research article
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity혈청 단백질체학으로 연구한 COVID-19에서 레닌-안지오텐신 시스템의 조절장애: 질병의 중증도에 따라 안지오텐시노겐 증가Article Published on 2022-04-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] ACE Activation AGT analyses Analysis angiotensin angiotensinogen bradykinin Cohort complement Complement activation Concentration convalescent coronavirus correlated COVID-19 COVID-19 infection CPN Critically ill critically ill patients disease severity expression expression analysis followed by group healthy probands hospitalized COVID-19 patients hospitalized patient hospitalized patients increase indicated Infection investigated Kallikrein Kallikrein-kinin system KLKB1 KNG1 mass spectrometry pathophysiological pathway patients plasminogen profile Protein protein expression proteomics RAS Renin renin-angiotensin system separated serum Serum protein significantly statistical System was performed [DOI] 10.3390/molecules27082495 PMC 바로가기 [Article Type] Article
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
Hepatitis B and C screening in hospitalized patients with SARS-CoV-2 infectionSARS-CoV-2 감염으로 입원한 환자의 B형 및 C형 간염 검사Article Published on 2022-04-012022-09-11 Journal: Gastroenterología y hepatología [Category] B형 간염, COVID19(2023년), SARS, 진단, 치료기술, [키워드] age Anti-HCV Antiviral treatment antiviral treatments candidate Comorbidities conducted Corticosteroid Corticosteroids COVID-19 Cribado Diagnosis diagnosis of COVID-19 died evaluate expected HBsAg HBV HBV infection HCV Hepatitis hepatitis B hepatitis C hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitals immunosuppressive Infection less limit male marker median age Older Patient patients with COVID-19 positive Prevalence Prevent previous diagnosis Prophylaxis Prospective Study Reactivation receive RNA SARS-CoV-2 SARS-COV-2 infection Screening screening program Spanish tested treated Treatment [DOI] 10.1016/j.gastrohep.2021.09.002 PMC 바로가기 [Article Type] Article
Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 RegistryObservational Study Published on 2022-04-012022-10-04 Journal: Internal and Emergency Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] Acetylsalicylic acid Admission affected Analysis analyzed Cardiovascular disorders collected coronavirus COVID-19 COVID-19 patients determine evaluate evaluated group Health Hospital admission hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU admission in-hospital mortality Inflammation intensive care large sample Mortality no difference outcome Patient patients with COVID-19 Pneumonia Propensity score Protective protective role PSM receiving registry retrospective cohort study Spanish symptomatic thrombosis Treatment was performed [DOI] 10.1007/s11739-021-02870-1 PMC 바로가기 [Article Type] Observational Study
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patientsShort communication Published on 2022-04-012022-10-05 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied association class correlation COVID-19 COVID-19 hospitalization Critically ill genetic marker Genome GWAS Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients independent initiative instrumental variable mendelian randomization obesity objective Patient platform reported Research design Result risk risk factor shown T2D type 2 diabete type 2 diabetes was performed [DOI] 10.1016/j.metabol.2022.155156 [Article Type] Short communication
Study of the effects of interferon β-1a on hospitalized patients with COVID-19: SBMU Taskforce on the COVIFERON study입원한 COVID-19 환자에 대한 인터페론 β-1a의 효과 연구: COVIFERON 연구에 대한 SBMU 태스크포스Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] addition Antiviral conducted control group coronavirus disease Coronavirus disease 2019 COVID-19 died Effect Efficacy group hospital Hospital admission Hospital stay Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients IFN-β1a immunomodulatory functions IMPROVE indicated innate immune system interferon Interferon β-1a interferons Iran median Mortality mortality rate no statistically significant difference outcome P-value Patient patients treated progression Randomized controlled trial regimen Retrospective study selected Severe case severe cases severe COVID-19 standard care standard treatment statistically statistically significant difference Tehran the interferon two group two groups [DOI] 10.1002/jmv.27475 PMC 바로가기 [Article Type] Article
Echocardiographic predictors of mortality and morbidity in COVID-19 disease using focused cardiovascular ultrasoundResearch article Published on 2022-04-012022-10-05 Journal: IJC Heart & Vasculature [Category] 바이오마커, 진단, [키워드] adverse outcome analyzed association Cardiac imaging center Clinical outcome conducted COVID-19 COVID-19 disease COVID-19 pandemic Critical diagnostic died dysfunction echocardiographic parameter echocardiography female highlight hospitalized COVID-19 patients hospitalized patient implication Infection invasive ventilation knowledge LV dysfunction morbidity Mortality multivariable model Patient performed predictor Prognosis prognostic renal replacement therapy Result Retrospective study risk RV dysfunction Shock significantly university utility Venous Thromboembolism ventricular with COVID-19 [DOI] 10.1016/j.ijcha.2022.100982 [Article Type] Research article
Sensitive and specific serological ELISA for the detection of SARS-CoV-2 infectionsSARS-CoV-2 감염 검출을 위한 민감하고 특이적인 혈청학적 ELISAArticle Published on 2022-03-192022-09-11 Journal: Virology Journal [Category] SARS, 치료기술, 치료법, [키워드] 113 patient 113 patients 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody levels Antibody titer Antibody titers approved Asymptomatic collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 cytomegalovirus develop early phase ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Enzyme-linked immunosorbent assay (ELISA) epidemiological data Epstein Barr virus Escherichia coli Hepatitis herpes simplex herpes simplex virus hospitalized COVID-19 patient hospitalized COVID-19 patients human serum identify IgG antibodies IgG immune response immune response immunodeficiency Infection Mild N-protein nucleocapsid protein Nucleocapsid protein (N-protein) number of infected pandemic Pathogens Patient PCR positive PCR test produced Protein provided purified remained RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2 specific antibodies SARS-CoV-2 spike sensitive sensitivity sera serological serological assays serological test serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe symptom severe symptoms specific IgG antibody specificity symptom onset symptomatic infections tested the SARS-CoV-2 triggered Vaccine virus [DOI] 10.1186/s12985-022-01768-4 PMC 바로가기 [Article Type] Article