host immunity – Page 5 – Communicable Diseases Research

Vitamins and other immune-supportive elements as cofactors for passing the COVID-19 pandemic

Review

Published on 2021-10-292022-10-28
Journal: Beni-Suef University Journal of Basic and Applied Sciences [Category] COVID-19,

The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes

다른 결과를 가진 코로나바이러스 질병 2019 환자의 동적 면역학적 매개변수 풍경

Immunology

Published on 2021-10-292022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] adaptive Adaptive immunity CD14 CD16 CD4 CD45RO CD8 Cell characterized cluster analysis coronavirus disease COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients cutoff value Deceased decrease demonstrated dendritic cell dynamic early phase enrolled expression highlighting HLA-DR host immunity Humoral immunity IgG IL-6 Immunity immunological immunological parameters Inflammatory marker Innate immunity involved landscape lymphocyte Mild Monocytes neutrophil Neutrophils NK cells objective outcome Patient patients Plasma cell Platelet Prognosis proinflammatory monocyte rapid increase reported restored Result severe patients sustained symptom onset systemically T cell T cells these cell
[DOI] 10.3389/fimmu.2021.697622 PMC 바로가기 [Article Type] Immunology

Traditional Chinese Medicine, Qingfei Paidu Decoction and Xuanfei Baidu Decoction, Inhibited Cytokine Production via NF-κB Signaling Pathway in Macrophages: Implications for Coronavirus Disease 2019 (COVID-19) Therapy

Pharmacology

Published on 2021-10-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] A549 cell A549 cells Activation addition analyzed anti-inflammatory activity Baidu Cell chemokine Chinese COVID-19 Cytokine storm Decoction defined demonstrated Efficacy ELISA evaluated expression expression level feature host immunity IFN IFN signaling pathway IFNα and IFNβ immune response in vitro infected with SARS-CoV-2 inhibited Innate immunity interferon-stimulated gene interleukin-6 investigated ISGs IκBα Ligand LPS Macrophage macrophage polarization macrophages marker mechanism Medicine modulation monocyte chemotactic protein-1 network pharmacology neutral red NF-κB signaling pathway NF-κB NF-κB signaling p65 pathway Patient PCR Phosphorylation pro-inflammatory pro-inflammatory cytokine Production Regulation robust RT-qPCR SARS-CoV-2 shown signaling pathway significantly suppressed THP-1 Traditional Traditional Chinese medicine treated Treatment tumor necrosis factor-α type 1 interferon were measured
[DOI] 10.3389/fphar.2021.722126 PMC 바로가기 [Article Type] Pharmacology

Structure-guided antibody cocktail for prevention and treatment of COVID-19

코로나19 예방 및 치료를 위한 구조유도항체 칵테일

Research Article

Published on 2021-10-212022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단,

[키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antivirals approach characterization chimeric chimeric antibodies Combination complex contagious coronavirus COVID-19 COVID-19 pandemic cryo demonstrated develop development disease Disease progression drug resistance drugs effective Efficacy Epitopes escape mutant escape mutants group host immunity in vitro in vivo Microscopy mitigate mutants neutralization activity neutralization test neutralize Neutralizing antibodies neutralizing antibody non-overlapping epitope non-overlapping epitopes Patient plaque reduction neutralization Plaque reduction neutralization test Post-infection Prevent prevent disease progression PRNT Prophylactic pseudovirus RBD Receptor-binding domain receptor-binding motif reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein suggested target the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic drug therapeutic effect therapy treat Treatment utility variants of SARS-CoV-2 Viral Viral load
[DOI] 10.1371/journal.ppat.1009704 PMC 바로가기 [Article Type] Research Article

Neutrophil-Dependent Immunity During Pulmonary Infections and Inflammations

Immunology

Published on 2021-10-192022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

SARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨

Article

Published on 2021-10-152022-09-11
Journal: Virus research [Category] SARS, 치료법,

[키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used
[DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

면역 탈출 변이체 추적을 위한 SARS-CoV-2 RBD 특이적 중화 항체의 결합 핫스팟에 대한 포괄적인 매핑

Research

Published on 2021-10-142022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] accumulation ACE2 binding additive effect Alanine Amino acid antibody antibody escape mutant Antibody-mediated neutralization antigenic antigenic site antigenic sites B.1.351 B.1.617.1 binding binding affinity changes in characterized circulating Comprehensive convalescent individual convalescent individuals convalescent plasma COVID-19 described determinant determinants domain E484K early stage escape mutation Escape variants Evidence Evolution F486L facilitate Host host immunity immune Immune escape impair independent K417N L452R memory B cell memory B cells Mutation N501Y NAb NAbs natural mutation neutralization Neutralizing antibodies neutralizing antibody not affect pandemic provide pseudoviruses RBD RBD antigenic sits RBD mutation RBD-specific antibody reactive Receptor-binding domain Recombinant protein recombinant proteins Result SARS-CoV-2 selected single B cell specific antibodies strain supplementary material Surveillance the RBD Treatment treatment of COVID-19 variant variants variants of SARS-CoV-2 virus was performed
[DOI] 10.1186/s13073-021-00985-w PMC 바로가기 [Article Type] Research

Shortening Epitopes to Survive: The Case of SARS-CoV-2 Lambda Variant

Article

Published on 2021-10-102022-10-28
Journal: Biomolecules [Category] COVID-19, SARS,

An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 Variants

Article

Published on 2021-10-062022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19

SARS 코로나바이러스 2 파파인 유사 프로테아제와 면역 체계 간의 상호 작용: COVID-19 치료를 위한 잠재적 약물 표적

Review

Published on 2021-10-012022-09-11
Journal: Scandinavian journal of immunology [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 complex complex system Compound coronavirus CoV COVID-19 CoVs cytokine production DeISGylating deubiquitinating drug drug target DUB dysregulation Effect enzyme evade Host host immunity immune immune response immune responses immune system infections inhibit inhibitor Innate innate immune responses MAPK Mild mild to moderate moderate molecules multifunctional New coronavirus NF-κB Papain Papain-like protease pathway Pathways PLPro protease public health regulate Respiratory tract infections respiratory virus respiratory viruses SARS Coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 STING suppress TGF-β Treatment treatment of COVID-19 upper respiratory tract upper respiratory tract infections viral spread viruses
[DOI] 10.1111/sji.13044 PMC 바로가기 [Article Type] Review