The species Severe acute respiratory syndrome-related coronavirus : classifying 2019-nCoV and naming it SARS-CoV-2Consensus Statement Published on 2020-03-022022-10-31 Journal: Nature Microbiology [Category] COVID-19, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] 2019-nCoV acute respiratory disease acute respiratory syndrome Applied microbiology Biodiversity clade clinical manifestation Committee complement Coronaviridae Study Group coronavirus coronavirus disease COVID-19 CSG Diseases ENhance Epidemic facilitate family Coronaviridae highlight Human human pathogen IMPROVE independent Microbiology outbreak Outbreaks pathogenic virus Phylogeny recognize Research responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection taxonomy the Coronaviridae Virology virus virus–host interaction while zoonotic transmission [DOI] 10.1038/s41564-020-0695-z PMC 바로가기 [Article Type] Consensus Statement
Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system박테리아 단백질 글리코실화 시스템에서 속 수준 글리칸 다양성의 유전적 결정인자Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Bacteria Bacterial bacterial pathogen bacterial species bacterial specy biosynthetic biosynthetic pathway biosynthetic pathways Comparative genomics component components conjunction conservation core genome determine driven by effort event Evolution Express expressed functional gene networks Genes Genetic genetic determinant genetic difference genetic interactions genus glycosylation Host Human human disease human pathogen identify independent influence instance instances Interaction involved isolate isolates loss-of-function Neisseria gonorrhoeae Neisseria meningitidis oligosaccharide oligosaccharides Pathogens pathway Pathways Perspective phylogenetically polymorphism post-translational modification Protein Recombination required robust selective status subset sugar sugars unique [DOI] 10.1371/journal.pgen.1008532 PMC 바로가기 [Article Type] Research Article
Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus InfectionsReview Published on 2019-10-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition alphavirus caused Clinical outcome Coronaviruses evade Genetic Host human pathogen immune evasion immune response immunopathology implicated Infection inflammatory disease Innate innate immune innate immune evasion innate immune response innate immune system interferon less molecular mechanism Pathogenesis pathology positive-sense single-stranded RNA viruses prevalent protective role public health replication capacity Research RNA single-stranded the interferon type I and III interferons viral disease viral infection viral pathogenesis virus viruses [DOI] 10.3390/v11100961 PMC 바로가기 [Article Type] Review
Precision mouse models with expanded tropism for human pathogensArticle Published on 2019-08-262022-11-01 Journal: Nature biotechnology [Category] Coronavirus, Fulltext, MERS, [키워드] Analysis Animal disease models autologous cell types cells clinically endothelial epithelial hematopoietic cells human immune response human lung tissue human pathogen humanized humoral implantation in vivo infect Infection lung lung tissue mice Microbiology Middle East mouse model pathogen Pathogens replicate respiratory syncytial virus respiratory syndrome coronavirus robust T-cell Response virus replication Zika virus [DOI] 10.1038/s41587-019-0225-9 PMC 바로가기 [Article Type] Article
Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In VitroObservation Published on 2018-04-182022-10-30 Journal: mSphere [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome approach cell membrane conformational change contribute coronavirus demonstrated domain Ebola virus ectodomain element event Factor fusion fusion protein glycoprotein human pathogen implicated indicate Influenza Influenza virus Interaction membrane-bound molecular Mutation observation occur prefusion promote Protein protein stability Proteins rabies Rabies virus residue SARS SARS CoV sedimentation equilibrium stability therapeutic thought TMD TMDs transmembrane domain trimeric ultracentrifugation undergo understanding viral entry viral envelope viral family virus [DOI] 10.1128/mSphere.00047-18 PMC 바로가기 [Article Type] Observation
The microbiota protects against respiratory infection via GM-CSF signaling미생물군은 GM-CSF 신호 전달을 통해 호흡기 감염으로부터 보호합니다Article Published on 2017-11-152022-09-14 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 폐렴구균 감염증, [키워드] Actinobacteria activate activating airway alveolar macrophage Bacteria Bacteroidetes clearance Clostridium Defense defined ENhance Enterococcus Extracellular firmicutes GM-CSF Gut Host human pathogen identify identity Immunity Increased Infection interleukin-17A intestinal killing Klebsiella pneumoniae lactobacillus lung Lung infection mechanisms mice microbiota pathogen promote PROTECT Proteobacteria regulate respiratory infection Signaling Staphylococcus aureus Staphylococcus epidermidis stimulate Streptococcus pneumoniae [DOI] 10.1038/s41467-017-01803-x PMC 바로가기 [Article Type] Article
Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent혈통에 의한 신원을 사용하여 지역 Plasmodium falciparum 말라리아 기생충 개체군 간의 연결성 정량화Research Article Published on 2017-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Accessibility Analysis approach assessment association Author best biological processe biological processes can not chance classic classical clinics collected data set descent detect disease dispersal Divergence drug resistance Ecology effort eliminating endangered species Epidemiology Evolution Genetic genomic data Genomics genotyped human pathogen IBD identity identity by descent increasingly inheritance knowledge Local malaria malaria parasite malaria parasites measure Molecular epidemiology nucleotide organism Organisms parasite Plasmodium falciparum Population power provide proximal Recombination required robust sampling sequenced significant decrease Single nucleotide polymorphism single nucleotide polymorphisms SNPs spatiotemporal Spread Surveillance Transmission transmission patterns whole genome [DOI] 10.1371/journal.pgen.1007065 PMC 바로가기 [Article Type] Research Article
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다Research Article Published on 2017-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition Bacterial battery Caenorhabditis Caenorhabditis elegans Cell cellular structure conserved Critical cytological damage Defense defense mechanisms described Diseases dysfunction Effect elegan elegans element Ethanol expand exposure to family functions genetics Health heat homeostasis Host host defense human pathogen hypothermia hypoxia Imbalance immune responses include increasingly indicate Infection innate immune response Innate immunity Interaction intestinal kill leads liquid mammals mechanism mechanisms mitigate mitochondrial organelle organism Organisms overlap overlapping oxidative damage P . aeruginosa pathogen Pathogens pathway Physiology Prevent Protein Pseudomonas aeruginosa pyoverdine recognizing Regulation required respond response secreted selective shown Stress stress response Surveillance threat Toxicity transcriptomics unique upregulation variety virulence [DOI] 10.1371/journal.pgen.1006876 PMC 바로가기 [Article Type] Research Article
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크Research Article Published on 2017-02-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] activity Algorithm Analysis Antibiotic resistance applied approach arising Bacteria Bacterial bases Beta-lactam beta-lactam antibiotics candidate cellular change chromosome coding sequence complement contribute Critical data set data sets dataset dihydrofolate Diversity DNA driver ENhance epistasis epistatic interaction epistatic interactions Evolution experimental work functions Genes Genetic variation Genome Genome-wide association studies Genome-wide association study genomic Genomic analysis genomic data highlight human pathogen hypothese hypotheses identify Interaction interactions lack Linkage disequilibrium loci locus non-susceptibility Organisms over parameter Pathogens pbp1a phenotype pneumococcus polymorphism Polymorphisms Protein pseudouridine recent representing reveal RNA sequence sequences significantly statistical statistical model statistically Streptococcus Streptococcus pneumoniae Streptococcus pyogene Streptococcus pyogenes structural biology synthases Systems biology target targets the strongest trimethoprim underlie virulence [DOI] 10.1371/journal.pgen.1006508 PMC 바로가기 [Article Type] Research Article
The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase VariationPilin N-말단 도메인은 Pilus 단계 변이 동안 Neisseria gonorrhoeae 변환 능력을 유지합니다Research Article Published on 2016-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Amino acid amino acids Antibiotic resistance antigenic variant antigenic variation Bacteria bacterium can not Cell cleavage cleavage site competence Critical Defense demonstrated DNA domain ELISA ELISAs exhibited fiber foreign DNA form function gene transfer genetic determinant genetic determinants gonococcal gonococcal infection gonorrhea horizontal gene Horizontal gene transfer human pathogen Immune escape Infection isolates killing lead locus maintain mechanism Microscopy morphology Mutagenesis Mutation N-terminal N-terminal domain N-terminus natural transformation Neisseria gonorrhoeae neutrophil nonsense mutation Nonsense mutations nucleotide occur pathogenic phase PilE pili pilin pilus producing Protein purification Recombination recombination event Release released required residue residues responsible retained sexually transmitted infection single nucleotide Spread strain Strains subunit the disease these cell These cells thought transfer transformation transmitted twitching Type Type IV pilus undetectable unique uptake variant while wild-type [DOI] 10.1371/journal.pgen.1006069 PMC 바로가기 [Article Type] Research Article