integrin – Page 5 – Communicable Diseases Research

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field

Review

Published on 2021-04-042022-10-31
Journal: Cancers [Category] COVID-19,

T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It Happen

회춘과 증폭을 위한 T 세포 주장; 뇌의 신경전달물질과 신경펩티드로 우리는 그것을 실현할 수 있습니다

Review

Published on 2021-03-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

[키워드] activate activated acute SARS-CoV-2 infection Adoptive Cell Therapy aging binding Brain Can Cancer Cell cell surface chemotactic chronic infections clinical trials CNS cytokine cytokine secretion damage decrease Depression diagnostic Dopamine Effect Effects Efficacy Ex vivo expressed extravasation Gene Expression Glutamate GnRH high risk Immunotherapy IMPROVE induce Infection infections Inflammation Injury integrin integrin-mediated killing limit microorganism microorganisms Migration Mortality natural Nerve-Driven Immunity nervous Neuropeptide Neuropeptide Y Neuropeptides neurotransmitter Neurotransmitters organization organizations other diseases other treatments overcome PD-1 proliferation protocols receptor Rejuvenation repeated SARS-COV-2 infection senescent Somatostatin Stress suggested System T cell T cells tested the cell therapeutic tissue repair trauma
[DOI] 10.3389/fimmu.2021.617658 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Entry Related Viral and Host Genetic Variations: Implications on COVID-19 Severity, Immune Escape, and Infectivity

SARS-CoV-2 진입 관련 바이러스 및 숙주 유전자 변이: COVID-19 심각도, 면역 탈출 및 감염성에 미치는 영향

Review

Published on 2021-03-172022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Adhesion Molecule Affect angiotensin antiviral drugs binding Cell contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determine driving drug enzyme escape Evolution genetic diversity genetic risk Genetic variation Genetic variations Genome geographical regions glycoprotein high risk Host host protein human population human populations immune Immune escape Impact in viral Infectivity integrin intercellular intercellular adhesion molecule Mutation Pathogenesis Pathogens Population Positive selection Precision protease Protein Receptor binding domain Research respiratory S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S glycoprotein SARS-CoV-2 variant SARS-CoV-2 variants Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity spike glycoprotein susceptibility the cell the SARS-CoV-2 TMPRSS2 transmembrane transmembrane protease serine 2 Transmissibility Transmission variants Variation Viral viral evolution viral S virus virus transmissibility vital role vital roles
[DOI] 10.3390/ijms22063060 PMC 바로가기 [Article Type] Review

The Mechanism of PEDV-Carrying CD3 + T Cells Migrate into the Intestinal Mucosa of Neonatal Piglets

Article

Published on 2021-03-122022-10-28
Journal: Viruses [Category] Coronavirus,

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

COVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다

Research Article

Published on 2021-03-112022-09-10
Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues
[DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article

Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential

Host-Microbe Interactions

Published on 2021-01-292022-10-28
Journal: Bioscience Reports [Category] COVID-19,

[키워드] bind binding binding site conserved COVID-19 COVID-19 pandemic COVID19 determinant determine develop Effect effective expressed help Human immune system Hypothesis ICAM-1 immune Immune cell integrin Interaction leukocyte leukocytes LFA1 Mac1 Macrophage macrophages molecular docking ORF7a orf7a protein predict Protein provide receptor required SARS-CoV2 structural homology T lymphocyte the disease
[DOI] 10.1042/BSR20203837 PMC 바로가기 [Article Type] Host-Microbe Interactions

Integrin, Exosome and Kidney Disease

Review

Published on 2021-01-252023-08-30
Journal: Frontiers in Physiology [Category] E형 간염,

[키워드] Exosome extracellular vesicle integrin kidney disease‐diagnosis kidney disease‐therapy
[DOI] 10.3389/fphys.2020.627800 PMC 바로가기 [Article Type] Review

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Review

Published on 2021-01-202022-10-28
Journal: Viruses [Category] COVID-19, MERS,

[키워드] ACE2 activate Activation aggregation Alternative pathway alveolar cell Amino acid amplify Angiogenesis B.1.1.7 binding Biological Blood Cell cell entry clinical Coagulation consequence Consequences contribute COVID-19 developmental domain dysregulation endothelial Endothelial cell ENhance enzyme Factor Factors high variability Host Hypothesis Impact impacts in viral include independent integrin integrin-mediated integrin-mediated signaling Integrins Interaction microthrombi modulated motif Mutation N501Y Numerous pathway Pathways Platelet Platelets Pneumocytes procoagulant receptor Receptor-binding domain resulting RGD motif SARS CoV-2 sequence Signaling signaling pathway spike Spike protein strain stroke suggested susceptibility the receptor-binding domain the SARS-CoV-2 virus the spike protein thrombosis thrombotic tissue tissue damage tissue microenvironment variant viral entry virion virion binding virus widespread
[DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

Review

Published on 2021-01-122022-10-04
Journal: Science Signaling [Category] 유전자 메커니즘,

[키워드] ACE2 affinity binding Amino acid sequences amino acids angiotensin-converting enzyme 2 assays autophagic autophagy autophagy machinery binding bioinformatics candidate cause Cell cell entry complex component components conserved COVID-19 cytoplasmic tail cytosolic develop Disease progression endocytic engage examined host cell host cell surface host-directed therapy hypothese identify implication integrin integrin signaling Integrins Interaction interactions linear mechanism membrane molecular motif overlap peptide Phosphorylation predict predicted Prevent Protein protein domain Proteins PTB receptor recruit regulated Regulatory Replication reported resource SARS-CoV-2 SARS-CoV-2 entry sequence Signaling subunit surface receptor therapeutic tyrosine Vertebrate viral infection viral spike protein virus
[DOI] 10.1126/scisignal.abd0334 PMC 바로가기 [Article Type] Review

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다

Comparative Study

Published on 2021-01-072022-09-10
Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘,

[키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus
[DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study