Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium1차 인간 기도 상피에서 SARS-CoV-2 향성의 단일 세포 분해능, 항바이러스 반응 및 요법에 대한 감수성Research Article Published on 2021-01-282022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 치료제, [키워드] airway epithelial cells airway epithelium Antiviral antiviral immunity antiviral responses antiviral therapies antiviral therapy array blocked Cell cell population cell type cell types cellular ciliated cell ciliated cells Ciliated epithelial cells contribute COVID-19 pathogenesis dominant element elements epithelial cell epithelial cell type epithelial cell types epithelial cells expressed Factor flow cytometry gene signatures heterogeneity heterogenous host protease host protease TMPRSS2 Human airway epithelium hyperinflammatory responses IL-6 induction infect infected cell infected cells Infection inhibited initial interferon interferon response ISG ISGs mediator outcome Pathogenesis predominant primary human airway Remdesivir required respiratory respiratory tract RNA-sequencing SARS-CoV-2 SARS-COV-2 infection secretory cell secretory cells Single Cell susceptibility susceptible therapy These cells TMPRSS2 Treatment Treatment response variety Viral viral replication viral tropism [DOI] 10.1371/journal.ppat.1009292 PMC 바로가기 [Article Type] Research Article
Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)Short Communication Published on 2021-01-052022-11-01 Journal: Virus research [Category] COVID-19, MERS, SARS, [키워드] Cell coronavirus disease Course COVID-19 COVID-19 patient COVID-19 severity decrease defined expressed expression Genes healthy controls IFN IFN alpha/beta IFN lambda IFNs Innate immunity interferon Invasive mechanical ventilation IRF7 ISG ISGs Oropharyngeal Patient required respiratory tract SARS-CoV-2 SARS-CoV-2 positive patient stimulated type I upper respiratory tract [DOI] 10.1016/j.virusres.2020.198283 PMC 바로가기 [Article Type] Short Communication
Interferon‐stimulated gene products as regulators of central carbon metabolismViewpoint Published on 2020-12-012022-10-31 Journal: The Febs Journal [Category] Coronavirus, MERS, SARS, [키워드] activate analyses Antigen antiviral immune response antiviral response biochemical carbon metabolism cellular COVID‐19 eicosanoid enzyme Evidence expression GAPDH gene product help immune response immunometabolism individual inhibit inhibiting innate immune response innate immune system interfere ISG ISGs mechanism metabolic product metabolite modulate modulating NFAT nitric oxide NOS Pathways performed Protein Proteins reaction regulate RSAD2 SAM stimulate Support viperin viral disease viral infections viral life cycle Viral proteins viral replication viruses [DOI] 10.1111/febs.15625 PMC 바로가기 [Article Type] Viewpoint
Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infectionResearch Article Published on 2020-11-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied Activation Antiviral effect Brain caused CD4 T cell cellular chemokine Chemokine receptor Clinical sign CNS contributing to coronavirus Coronavirus infection Critical CX3CL1 CX3CR1 cytokine deficiency develop dissemination expression functions IFN IFNs immune protection Infection infiltration interferon-induced protein ISG ISGs lack leukocyte mechanism mice microglial Migration morbidity and mortality murine Neurological deficit neurotropic NK1.1 Pathogenesis PROTECT protective mechanism Protein receptor recruitment reduced regulate restrict significantly Spread stimulated Symptom T cell tissue homeostasis viral clearance Viral load viral replication virus virus load virus replication viruses wild-type [DOI] 10.1371/journal.ppat.1009034 PMC 바로가기 [Article Type] Research Article
Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling PathwaysImmunology Published on 2020-11-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating approach biological activity canonical cells clinical implication consequence COVID-19 Critical cytoplasm element event Evidence group of disease IFN-stimulated gene IFNs immune response interferon ISG ISGs JAK/STAT mammalian target of rapamycin MAP kinase signaling mRNA translation nucleus outcomes Pathways positive Protein SARS-CoV-2 Signal transducer and activator of transcription Signaling signaling cascade signaling pathways Transcription transcriptional activation treat Type Type I IFN type I interferon [DOI] 10.3389/fimmu.2020.606456 PMC 바로가기 [Article Type] Immunology
In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesisResearch Article Published on 2020-11-112022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract AKT1 Analysis approach ARDS Cancer candidate cascades Cell changes Coagulation coagulation cascade complement Complication computational analysis COVID-19 Critical Critical case Cytokines storm degranulation degree downstream driver expression Fold change Gene ontology globe host proteins Huh7 IFN-I in silico in vitro in vitro study include Infection inhibit intravascular coagulation IRAK1 IRF3 IRF7 ISG ITGAM KEGG pathway analysis knowledge lack MAPK signaling MAPK1 MAPK1/MAPK3 MAPK3 MAVS mechanism medical intervention mitigate MOST neutrophil degranulation overlap pathway Pathways PD-L1 platelet activation predicted Protein proteomic public health emergency receptor signaling Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 patients Signaling signaling pathway similarity Spread SRC STOM therapeutic targeting thrombosis thrombotic TNF TP53 Traf6 Transcriptome up-regulated VAMP8 viral infection viral pathogenesis [DOI] 10.1016/j.csbj.2020.11.005 PMC 바로가기 [Article Type] Research Article
Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection코로나바이러스에 의한 숙주 세포 수용체-안지오텐신-전환 효소 2 발현 증가는 2019-nCoV(또는 SARS-CoV-2) 감염을 촉진할 수 있습니다Article Published on 2020-11-012022-09-11 Journal: Journal of medical virology [Category] SARS, 유전자 메커니즘, [키워드] 2019-nCoV accelerate ACE2 ACE2 binding ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cellular cellular entry receptor cellular receptor China Cluster coronavirus coronavirus disease Coronaviruses COVID-19 cytokine Cytokines drugs targeting Emerging infectious diseases Epidemic expression facilitate Factor Host host cells Human humans IFN Increasing induce Infection Infectious disease Infectious diseases Inflammatory cytokine Inflammatory cytokines interferons ISG much higher nCoV New coronavirus outbreak Protein public health receptor-angiotensin-converting enzyme 2 Region Replication respiratory risk S protein SARS-CoV S protein SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus significantly spread to Stimulation the SARS-CoV-2 transmitted upregulated virus viruses [DOI] 10.1002/jmv.26139 PMC 바로가기 [Article Type] Article
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor Research Published on 2020-10-192022-10-05 Journal: Nature Genetics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome amino acids angiotensin-converting enzyme 2 atlas binding cause cellular entry Co-infection condition coronavirus COVID-19 expression full-length SARS-CoV-2 independent induce Infection Inflammatory interferon-stimulated gene ISG isoform lack outcomes promote receptor SARS-CoV-2 Spike protein susceptibility target cells the SARS-CoV-2 transcriptionally Tumor tumor microenvironment unlikely Variability virus [DOI] 10.1038/s41588-020-00731-9 [Article Type] Research
Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study라이노바이러스와 인플루엔자 A 바이러스의 간섭: 임상 데이터 분석 및 실험적 감염 연구Article Published on 2020-10-092022-09-10 Journal: The Lancet. Microbe [Category] MERS, 신종인플루엔자, 치료기술, [키워드] 95% CI Affect airway Analysis Antiviral blocking Cell culture cell cultures Clinical data co-occurrence Course COVID-19 pandemic Culture decrease Department Epidemic Epidemics epithelial Europe European country examination expected expression finding fluorescent Frame funding GFP green fluorescent protein H1N1 H1N1pdm09 host cell IAV idea inclusion criteria indicated Infection Influenza influenza A influenza A virus inhibit inoculated Interference interferon interferon response interferon-stimulated gene interferon-stimulated genes Intervention ISG ISGs medical record Medical Sciences Medicine Microscopy mock infection MOI mRNA mucosa Multiplex PCR multiplicity multiplicity of infection Odds ratio pandemic positive Post-infection primary human airway Protein quantitative PCR Replication reporter respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory virus restored resulting reverse transcription Reverse transcription quantitative PCR rhinovirus RNA Seasonal influenza significantly lower Spread Stimulation subsequent System tested the interferon Time frame USA Viral Viral RNA virus was used [DOI] 10.1016/s2666-5247(20)30114-2 PMC 바로가기 [Article Type] Article
Two distinct immunopathological profiles in autopsy lungs of COVID-19Article Published on 2020-10-082022-10-04 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] activated acute respiratory syndrome Autopsy Biomarker caused CD8 cellular characterized coronavirus COVID-19 COVID-19 patient Cytokines damaged differential expression Disease progression expression feature highlight histologic Hospitalization immune response Immunopathogenesis immunopathological Infection infiltrating interferon ISG ISGs Local lung lung damage Lung disease lung tissue Lungs macrophages Mortality normal lung tissue pathogenic Patient patients Peripheral blood profile progression pulmonary damage reaction pattern Respiratory disease SARS-CoV-2 SARS-COV-2 infection Sequencing significantly Stage stimulated T cell tissue transcriptomic Treatment viral infection Viral load viral loads worldwide pandemic [DOI] 10.1038/s41467-020-18854-2 PMC 바로가기 [Article Type] Article