isolates – Page 5 – Communicable Diseases Research

Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan

일본 히로시마에서 Sanger 시퀀싱 전략을 사용한 SARS-COV-2 변이체의 질량 스크리닝

Article

Published on 2022-02-142022-09-01
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2

SARS-COV-2에 대한 세포 독성 반응에 대한 바이러스 돌연변이 풍경의 영향 예측 된 영향

Research Article

Published on 2022-02-102022-09-10
Journal: PLoS Computational Biology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종,

[키워드] accumulation adaptive affected affecting Algorithm allele Allele families allele family alleles antibodies Asian Author C-terminal change changes in Cluster complexity country COVID-19 susceptibility Critical Cytotoxic T cell deletions eight epitope Epitopes escape escape mutation event except for extreme facilitated genetic background genetic variability genetics Genome genomic HLA class I human allele human population humans immune evasion immune response independent information integration involved isolate isolates Ligand ligands local outbreaks Mutation mutations NCBI Neutralizing occurred pandemic Pandemics Population predicted Prevent Primary infection Protective proteome protocol reduction Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome selective subpopulations Substitution Support surpassed Surveillance susceptible T cell T cell response the SARS-CoV-2 unlikely Variability variant variants Viral viral genome viral genomes viral mutation Viral mutations viral variant virus
[DOI] 10.1371/journal.pcbi.1009726 PMC 바로가기 [Article Type] Research Article

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

SARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다

Research Article

Published on 2022-02-082022-09-10
Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while
[DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article

Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines

Article

Published on 2022-02-052022-10-28
Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS,

[키워드] Adults age airway arising Cell Cell culture cell lines cells changes in children cleavage site co-morbidities Cohort Culture Delta dependent on driving epithelial Evidence Evolution Factor fixation Genetic genetic diversity genotypic growth highlight Host host cell factor host cells human respiratory epithelium in vitro infect isolate isolates LINE morbidity and mortality Mutation nasal passages phenotypic plasticity polybasic primary airway epithelial cells reduced remained respiratory epithelial cells resulting SARS-CoV-2 SARS-CoV-2 evolution several variant spike Strains variant Vero Vero cells viral evolution Virus evolution VoC whole-genome sequencing
[DOI] 10.3390/v14020325 PMC 바로가기 [Article Type] Article

SARS‐CoV‐2 intralineage variation and temporal patterns of COVID‐19 risk factors in three cities of southeastern Brazil: Age, sex, and race

Research Article

Published on 2022-02-012022-10-04
Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 치료기술,

COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis – California and New York, May-November 2021

COVID-19 예방 접종 상태 및 이전 COVID-19 진단에 따른 COVID-19 사례 및 입원 - 캘리포니아 및 뉴욕, 2021년 5월-11월

Article

Published on 2022-01-282022-09-11
Journal: Morbidity and Mortality Weekly Report [Category] 변종,

[키워드] accounted analyzed booster dose booster doses both group both groups cause changed Cohort cohorts completion COVID-19 COVID-19 case COVID-19 diagnosis COVID-19 incidence COVID-19 vaccination death deaths declined delta variant diagnoses Diagnosis diagnosis of COVID-19 Duration of infection eligible Epidemic Epidemiology highest Hospitalization hospitalizations immune evasion Immunity immunization Immunologic Infection infection with SARS-CoV-2 isolates laboratory-confirmed magnitude New New York occurred omicron outcome predominant Prevent previous diagnosis PROTECT public health recommendation Reinfection SARS-COV-2 infection SARS-CoV-2 infections sequenced status study period Surveillance the SARS-CoV-2 three groups vaccination vaccine dose vaccine doses Vaccine-induced immunity variants virus with COVID-19
[DOI] 10.15585/mmwr.mm7104e1 PMC 바로가기 [Article Type] Article

Emerging genetic diversity of SARS-CoV-2 RNA dependent RNA polymerase (RdRp) alters its B-cell epitopes

SARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp)의 유전적 다양성이 B 세포 에피토프를 변경

Article

Published on 2022-01-012022-09-11
Journal: Biologicals : journal of the International Associa [Category] SARS, 변종,

The Usage of Antibiotics by COVID-19 Patients with Comorbidities: The Risk of Increased Antimicrobial Resistance

Article

Published on 2021-12-292022-10-27
Journal: Antibiotics [Category] COVID-19,

[키워드] antibiotic antibiotic susceptibility Antibiotics antimicrobial antimicrobial resistance antimicrobial resistance pattern Antimicrobial stewardship AST Bacterial Bacterial infection Bacterial infections carbapenem Care Chronic kidney disease CKD clinical clinical implication clinics collected Comorbidities Comorbidity conducted COVID-19 COVID-19 patient diffusion method E. coli Health hospital ICU Patients identify Immunocompromised patients Increased inhibitory concentration intensive care unit isolates Klebsiella pneumoniae Local morbidity and mortality MOST pathogen Prevalence prevalent provide resistance surgical susceptibility the patient Treatment urinary tract infection Usage use of antibiotics widespread
[DOI] 10.3390/antibiotics11010035 PMC 바로가기 [Article Type] Article

Evolution of enhanced innate immune evasion by SARS-CoV-2

SARS-CoV-2에 의한 강화된 타고난 면역 회피의 진화

Article

Published on 2021-12-232022-09-10
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법,

[키워드] Activation adaptation airway airway epithelial cell airway epithelial cells Alpha Alpha variant antagonists assays association B.1.1.7 changes in characterization coding region contribute Delta Duration of infection effective effort ENhance epithelial cells expression first-wave Human human-to-human transmission immune responses increase increase in innate immune innate immune response innate immune responses Interaction isolate isolates lead likelihood MAVS mitochondrial Mutation nucleocapsid protein observation omicron ORF6 Orf9b Phosphoproteomics Phosphorylation Protein protein level protein levels Proteins proteomics regulated regulatory region Replication required RNA RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein suppress suppresse suppressed Systems biology the spike protein Transmission upregulation variant variants variants of concern Viral viral adaptation viral replication
[DOI] 10.1038/s41586-021-04352-y PMC 바로가기 [Article Type] Article

Increased Use of Antibiotics in the Intensive Care Unit During Coronavirus Disease (COVID-19) Pandemic in a Brazilian Hospital

Pharmacology

Published on 2021-12-102022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] analyses analyzed anti-infective agents antibiotic Antibiotics autocorrelation Bacteria Bacterial Bacterial infection calculated classification Coinfection concerning contribute COVID-19 COVID-19 pandemic daily dose defined drug resistance hospital ICU Increased infections intensive care unit intensive care units isolate isolates MDR medication multidrug-resistant nine overlap pathogenic agent Patient performed Polymyxin B Primary outcome problems public health regression models reserve retrospective secondary outcome Spread therapeutic treat Treatment use of antibiotics World Health Organization
[DOI] 10.3389/fphar.2021.778386 PMC 바로가기 [Article Type] Pharmacology