T and B cell Epitope analysis of SARS‐CoV‐2 S protein based on immunoinformatics and experimental researchOriginal Article Published on 2020-12-152022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] Analysis Antigen antigenic epitope antigenicity antigens antiviral therapy B cell B cell epitopes can be used caused complex conserved COVID‐19 develop docking effective Fatality rate highest HLA identify immunoinformatics induce Interaction isolate lack leucocyte Molecular dynamics simulation morbidity and mortality Novel coronavirus pandemic peptide peptide epitope predicted Prevent Research S protein SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 selected T and B cell epitopes T cell T cell epitope T cell epitopes T cell immune response T cell response target Vaccine Vaccine design [DOI] 10.1111/jcmm.16200 PMC 바로가기 [Article Type] Original Article
Association between biomarkers and COVID-19 severity and mortality: a nationwide Danish cohort study바이오마커와 COVID-19 심각도 및 사망률 사이의 연관성: 덴마크 전국 코호트 연구Article Published on 2020-12-022022-09-11 Journal: BMJ Open [Category] MERS, SARS, 바이오마커, [키워드] adjusted Admission adult intensive & age and gender Analysis association baseline level baseline levels Biochemistry Biomarker Biomarkers Bootstrapping C reactive protein cohort study Composite composite endpoint COVID-19 severity Critical Critical care CRP D-dimer death Denmark died Diseases EGFR elevated evaluate filtration rates general medicine (see internal medicine) glomerular filtration rate hospital ICU Infectious diseases Intensive intensive care intensive care unit internal medicine leucocyte leucocytes median age National normal outcome Patient patients with COVID-19 procalcitonin registry data retrospective cohort study risk significantly higher troponin urea ureas with COVID-19 [DOI] 10.1136/bmjopen-2020-041295 PMC 바로가기 [Article Type] Article
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular ScienceCOVID-19의 내피 기능 장애: 죽상경화증 및 혈관 생물학을 위한 ESC 실무 그룹 및 ESC 기초 심혈관 과학 위원회의 입장 보고서Review Published on 2020-12-012022-09-11 Journal: Cardiovascular Research [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome addition Affect affected affecting angiotensin angiotensin-converting enzyme 2 ARDS Arrhythmias Atherosclerosis basic Biology Biomarker cardiac effects Cardiology cardiovascular cardiovascular complication cardiovascular complications cardiovascular system Coagulation contribute convalescent COVID-19 patient convalescent COVID-19 patients Council COVID-19 COVID-19 pandemic COVID-19 patients cytokine cytokine release Cytokine storm Disseminated intravascular coagulation driver dysfunction Early detection Effect Effects endothelial Endothelial cell endothelial cells endothelial function Endothelium European evaluated Evidence evidence of expression fatal COVID-19 Follow-up group healthcare identify include infection with SARS-CoV-2 Inflammatory intravascular coagulation Kawasaki disease leucocyte Lungs Mortality myocardial damage myocarditis pathophysiology Patient position Prevalence question receptor recruitment required Research respiratory distress Respiratory distress syndrome risk stratification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Science Society syndrome systemic inflammatory the SARS-CoV-2 virus tissue damage Vascular endothelium vasculature Vasculitis working [DOI] 10.1093/cvr/cvaa230 PMC 바로가기 [Article Type] Review
Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques면역 정보학 및 구조 기반 약물 발견 기술을 사용하여 잠재적 치료제를 위한 SARS-CoV2 뉴클레오캡시드 단백질 표적화Article Published on 2020-12-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, 치료제, [키워드] Analysis antigens approach B-cell B-cell epitope B-cell epitopes bioinformatics candidate complex coronavirus Coverage COVID-19 Critical docking Drug discovery epitope Epitope-based vaccine Epitopes help identify IFN-γ Immunity Immuno-informatics induce inhibitor leucocyte life cycle molecular dynamics Molecular dynamics simulation N protein N-protein N-terminal domain non-allergenic non-toxic nucleocapsid nucleocapsid protein Occurrence Protein ribonucleoprotein SARS-CoV2 SARS-CoV2 infection sequence Stage Structure T-cell epitope T-cell epitopes targeting the N protein therapeutic intervention therapeutic interventions therapeutic option therapeutic options Vaccine Viral viral genome viral life cycle zidovudine zidovudine triphosphate [DOI] 10.1016/j.biopha.2020.110914 PMC 바로가기 [Article Type] Article
The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory InvestigationGenetics Published on 2020-11-092022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Affect affected Analysis analyzed atmospheric biological process booster cardiovascular disease Cell cellular change Characteristics Coagulation coagulation disorders collected contributing to COVID-19 COVID-19 outbreak Cytokine storm Cytokines storm diabete disease distribution endothelial environmental factor Environmental pollution epidemiological Evidence exacerbating Factor Gene Expression gene network growth Hypothesis immune response Inflammatory response Influenza virus investigation involved Italy key factor leucocyte matter modulated modulation molecular molecular mechanisms Molecular signatures molecular target Mortality novel coronavirus disease organ Outbreaks Particulate Particulate matter pathogen pathway Proteins public health receptor receptors cross-talk reproductive SARS-CoV-2 Spread Support Symptom theory therapeutic approaches Toxicity transendothelial migration transmembrane Treatment triggered virus carrier [DOI] 10.3389/fgene.2020.579964 PMC 바로가기 [Article Type] Genetics
The role of host defences in Covid 19 and treatments thereofReview Published on 2020-09-292022-10-30 Journal: Molecular Medicine [Category] COVID-19, [키워드] age ATP boost carbon monoxide catalytic activity cause Chloroquine circulating clinical manifestation clinically co-morbidity coding COVID 19 Critical distribution Donor Efficiency endothelial damage enveloped RNA virus event explain genetic trait growth Guidance heme oxygenase 1 hemoglobin HMOX1 Host hydrogen Hydrogen sulfide include Infection Inflammatory cytokines inhibit Interaction involved leucocyte lung infiltration mechanical ventilation mechanism modulate Paracetamol pathogenic mechanism predicted promoter Protein SARS-CoV-2 Sex shown survivor susceptibility therapeutic intervention Therapeutic strategies Treatment triggered variety [DOI] 10.1186/s10020-020-00216-9 PMC 바로가기 [Article Type] Review
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes단핵구 감소증, 단핵구 형태 이상 및 과염증은 제2형 당뇨병에서 중증 COVID-19의 특징입니다Observational Study Published on 2020-09-112022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상, [키워드] COVID‐19 SARS‐CoV-2 aetiology Affect aggravate Anomaly Care Cell change changes in circulating classical Cohort condition contribute COVID diabetes Diabetic disease course Evidence expression gene expression profile group hospitalised hyperinflammation Hyperinflammatory identifying IL 6 Immune cell immune cells immune response immune responses immunology immunophenotype Increased increased expression Inflammation Inflammatory Inflammatory marker inflammatory markers intensive care interferon leucocyte lymphocyte Lymphocytes lymphocytopenia metabolism Microbiology, Virology & Host Pathogen Interaction mitigate monocyte Monocytes monocytopenia Morphological morphology Mortality observational study pandemic pathway Patient patients peripheral circulation personalised Population precision therapy quantified risk factor severe disease severity T2D target therapeutic target type 1 interferon type 2 diabete type 2 diabetes Variation variations [DOI] 10.15252/emmm.202013038 PMC 바로가기 [Article Type] Observational Study
Role of Biochemical Markers in Invasive Ventilation of Coronavirus Disease 2019 Patients: Multinomial Regression and Survival AnalysisInternal Medicine Published on 2020-08-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% confidence interval acute respiratory distress acute respiratory syndrome Admission Affect age airway Analysis applied biochemical marker C-reactive protein (CRP carried conducted contributing to coronavirus coronavirus disease COVID-19 COVID-19 patients creatinine CRP D-dimer death discharge disease distributions elevated female group hemoglobin hospitalized COVID-19 patients hypernatremia ICU Infectious diseases intensive care invasive invasive ventilation Kaplan-Meier survival curve Laboratory laboratory investigation lactate dehydrogenase LDH leucocyte Leukocytosis log-rank test Lungs Lymphocytes lymphocytopenia males marker material Mortality multinomial logistic regression multinomial regression Neutrophils Non-invasive non-invasive ventilation non-survivor observation Odds ratio Pakistan pandemic pathogen Patient patients PCT positive positive airway pressure predict presenting Pulmonology raised Regression Respiratory failure Respiratory Support Respiratory system responsible Result risk stratification role SARS-CoV-2 serum Serum ferritin serum sodium significantly sodium statistically subject Supplemental oxygen therapy survival survivor syndrome the patient urea Ventilated Ventilation ventilator was performed [DOI] 10.7759/cureus.10054 PMC 바로가기 [Article Type] Internal Medicine
Clinical characteristics of confirmed and clinically diagnosed patients with 2019 novel coronavirus pneumonia: a single-center, retrospective, case-control studyArticle Published on 2020-07-282023-06-16 Journal: Medicina clínica [Category] MERS, SARS, [키워드] Características clínicas Citocina Clinical characteristics Clinically diagnose Confirmado Confirmed coronavirus COVID-19 cytokine Diagnóstico clínico Leucocito leucocyte Prognosis pronóstico SARS-CoV-2 [DOI] 10.1016/j.medcli.2020.06.055 PMC 바로가기
A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patientsOriginal Article Published on 2020-07-052022-10-30 Journal: International journal of immunogenetics [Category] COVID-19, MERS, SARS, [키워드] 95% CI analysed Analysis Antigen association case/control studies Clinical management Cohort Comparator group controls Deceased disease association disease association studies Donor Frequency genetics histocompatibility HLA HLA frequency human leucocyte antigens immune response immunology individual infected patients Infection information Interaction leucocyte molecular pandemic Patient Population positive protective effect representing RNA SARS‐CoV‐2 Severe acute respiratory syndrome Support susceptibility tested Virology virus [DOI] 10.1111/iji.12505 PMC 바로가기 [Article Type] Original Article