Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunitySARS-CoV-2 변이 스파이크 에피토프의 인식에서 벗어나 T 세포 면역의 전반적인 보존Article Published on 2022-02-092022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Ability to protect Affect African Beta Beta variant CD4 CD4 T cells CD8 CD8 T cell CD8 T cell responses COVID-19 patient detectable dominant Efficacy epitope Epitopes escape explain First wave first-wave immune evasion Immunity immunogenic mounted mutated neutralization neutralizing antibody observation Patient patients peptide peptides preserved proportion PROTECT Recognition recognize Region regions Reinfection residue response retained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 severe disease South spike epitope spike epitopes spike mutation spike mutations T cell T cell response T cell responses T cells tested Vaccine vaccine efficacy variant wild-type Wuhan strain [DOI] 10.1126/scitranslmed.abj6824 PMC 바로가기 [Article Type] Article
Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα항-TNFα 치료를 받은 염증성 장 질환 환자의 코로나19 mRNA 백신에 대한 혈청학적 반응 감소Observational Study Published on 2022-02-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] administration adverse event adverse events AEs all subject all subjects Anti-spike anti-spike antibody anti-TNF antibody BNT162b2 booster dose comparable coronavirus disease COVID-19 dose doses drug level drug levels enrolled function functional groups HCs healthy control healthy controls high risk IBD infection rate infections Inflammatory bowel disease inflammatory bowel diseases inhibitory Lower magnitude Messenger RNA mounted mRNA mRNA-BNT162b2. multicenter Necrosis not affect Patient patients treated Pfizer Pfizer/BioNTech Prospective Prospective Study remained response Safe safety profile second dose serologic Serologic response serologic responses seronegative seropositive significantly lower stratified therapy TNFα treated treated patients Treatment Vaccine vaccine dose vaccine response vaccine responses [DOI] 10.1053/j.gastro.2021.10.029 PMC 바로가기 [Article Type] Observational Study
Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial기준 항체 및 항원 수준에 따른 COVID-19 입원 환자의 중화 단일클론항체에 대한 반응: 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] allergy Analysis analyzed Anti-spike antibodies antibody Antigen bamlanivimab baseline benefit clinical trial collected Combination Controlled COVID-19 death defined detectable discharge elevated end-organ evaluate evidenced favor futility Government greater hazard hazard ratios hospitalized patient hospitalized patients Hypothesis immune IMPROVE independent Infectious diseases Interaction Level limited sample size median median time monoclonal antibody mounted Multicenter trial NAb NAbs nasal neutralizing antibody not differ operation Organ failure outcome participant Patient patients with COVID-19 Placebo placebo group placebo-controlled placebo-controlled trial plasma Randomized receiving Remdesivir required response SARS-CoV-2 nucleocapsid Serious Adverse Events serious infections serostatus small sample size specimen speed subgroup subgroup analysis sustained the median therapy Trial Viral Viral RNA with COVID-19 [DOI] 10.7326/M21-3507 PMC 바로가기 [Article Type] Randomized Controlled Trial
Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting TherapyB 세포 고갈 요법을 받는 ANCA 관련 혈관염 환자에서 SARS-CoV-2 백신 접종 후 항원 특이적 체액 및 세포 면역Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] ANCA-associated vasculitis anti-CD20 anti-CD20 therapy anti-SARS-CoV-2 Anti-spike antibody assays B-cell B-cells cellular Cellular immune response characterized control subjects controls COVID-19 vaccination elicit ELISPOT enzyme-linked immunosorbent humoral humoral immune response Humoral response immune responses immunoassays interferon lack mounted Patient patients peptide peptide pool positive Protective protective effect receiving Receptor binding domain recovered patient Research response rituximab robust S glycoprotein SARS-CoV-2 SARS-CoV-2 vaccination Specific Specific T-cell response subject subjects subunit T-cell immunity T-cell Response T-cell responses targeted therapy vaccination Vaccine vaccine response Vasculitis were measured [DOI] 10.3389/fimmu.2022.834981 PMC 바로가기 [Article Type] Immunology
Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA VaccinationmRNA 백신 접종 후 치명적인 코로나19 감염에 대한 중간 정도의 면역 반응Immunology Published on 2022-01-252022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, 치료기술, 치료법, 치료제, [키워드] Alpha Alpha variant Alpha VOC analyzed anti-SARS-CoV-2 vaccination Antibody titers antigenic target Breakthrough infection CD4+ CD4+ T-cell CD8+ T cell CD8+ T cells cellular Cohort COVID-19 COVID-19 disease detectable disease manifestation disease onset Disease progression donors Endemic fatal COVID-19 had no humoral immune response Humoral immunity Inclusion indicate individual moderate mounted mRNA mRNA-based Neutralizing antibodies Neutralizing antibody titer Patient reduced response resulting robust S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants T cells T-cell Response Trigger uninfected Vaccination strategy Vaccine vaccine breakthrough infection variant VoC VOCs wild type [DOI] 10.3389/fimmu.2022.816220 PMC 바로가기 [Article Type] Immunology
Immunogenicity of The BNT162b2 COVID-19 mRNA and ChAdOx1 nCoV-19 Vaccines in Patients with HemoglobinopathiesArticle Published on 2022-01-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition anti-N antibodies assays AstraZeneca asymptomatic infection AZD1222 binding antibody BNT162b2 BNT162b2 mRNA booster dose ChAdOx1 nCoV-19 collected COVID-19 COVID-19 vaccine dose Gender Hemoglobinopathy high risk Hyperferritinemia immune response Immunity immunogenicity Infection mounted mRNA NAb neutralizing antibody not affect participant Patient Pfizer Pfizer-BioNTech positive response Post-vaccine receive receiving serum Sickle cell disease significantly spleen thalassemia the vaccine thought Vaccine while [DOI] 10.3390/vaccines10020151 PMC 바로가기 [Article Type] Article
Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunityArticle Published on 2022-01-012022-11-15 Journal: Gut Microbes [Category] SARS, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody Antibody titer Bacteria binding collected commensal gut bacteria correlated COVID-19 vaccine cross-react cross-reactive cross-reactive antibody demonstrated DNA vaccine domain dominant dose E. coli Efficacy epitope fecal Gut gut bacteria gut microbiota healthy Host Hsp60 Hsp70 Immunity immunized Impact inactivated LC-MS metagenomic sequencing mice microbial monoclonal antibodies monoclonal antibody mounted naïve P144 Protein RBD binding reactive S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 vaccination SPF Spike protein Vaccine vaccine immunogenicity variety [DOI] 10.1080/19490976.2022.2117503 PMC 바로가기
Impact of tozinameran (BNT162b2) mRNA vaccine on kidney transplant and chronic dialysis patients: 3-5 months follow-up신장 이식 및 만성 투석 환자에 대한 tozinameran(BNT162b2) mRNA 백신의 영향: 3-5개월 추적Article Published on 2022-01-012022-09-11 Journal: Journal of Nephrology [Category] SARS, 치료기술, [키워드] antibody Antibody Response BNT162b2 calcineurin Cancer changes in cohort study Control controls COVID-19 COVID-19 mRNA Vaccination Determining diabetes dialysis drug level End-stage renal disease events Factor ferritin Follow-up healthcare Hemodialysis humoral humoral immunogenicity hypertension identify IgG antibody Impact Infection infection rate infections kidney transplant kidney transplant recipients Kidney transplantation log lymphocyte Lymphocyte count measure modality morbidity mounted mRNA vaccination mRNA vaccine mTOR mTOR inhibitor Older age Patient patients Peritoneal dialysis PROTECT recipient reduced renal renal disease renal replacement therapy replacement therapy required risk Risk assessment S1/S2 Serum ferritin Subsequent infection vaccination Vaccine Vaccines viral infections women [DOI] 10.1007/s40620-021-01210-y PMC 바로가기 [Article Type] Article
COVID-19 pandemic waves: how prepared is West Africa for managing a high COVID-19 caseload? Urgent actions neededCommentary Published on 2021-12-212022-10-28 Journal: The Pan African Medical Journal [Category] Coronavirus, SARS, [키워드] concerning Coverage COVID-19 COVID-19 pandemic ENhance genomic Genomic surveillance Health immunization IMPROVE knowledge mounted pandemic PROTECT Region Surveillance vaccination Waves West [DOI] 10.11604/pamj.2021.40.249.31107 PMC 바로가기 [Article Type] Commentary
Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응Immunology Published on 2021-12-132022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread [DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology