natural killer cell – Page 5 – Communicable Diseases Research

High Levels of Interferon-Alpha Expressing Macrophages in Human Breast Milk During SARS-CoV-2 Infection: A Case Report

SARS-CoV-2 감염 중 인간 모유에서 높은 수준의 인터페론-알파 발현 대식세포: 사례 보고

Case Reports

Published on 2021-05-012022-09-12
Journal: Breastfeeding medicine : the official journal of t [Category] SARS, 진단,

Maternal natural killer cells at the intersection between reproduction and mucosal immunity

Review Article

Published on 2021-04-262022-10-31
Journal: Mucosal Immunology [Category] COVID-19, MERS,

Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3 + CD8 + T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission

COVID-19 이환율 통계의 연령 분포에 따라 계층화된 연령 집단은 입원 시 동반 질환이 없는 COVID-19 환자에서 고유하게 연령 의존적 CD3 + CD8 + T 세포 림프구감소증을 식별합니다

Research Paper

Published on 2021-03-312022-08-31
Journal: Aging (Albany NY) [Category] SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age age distributions age-dependent immune features Analysis B cell C-reactive protein C-reactive protein concentration can be used CD3 CD4 CD8 CD8+ T cells cell count Cohort Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients defined develop distribution feature FIVE help identify immune indicated Infection Killer cell lymphocyte Lymphocyte count lymphocyte counts Lymphocyte subsets lymphocytopenia lymphopenia morbidity morbidity statistics natural killer natural killer cell not differ Pathogenesis patients plasma respiratory Retrospective study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significantly Statistics stratified susceptibility T cell T cells T-cell the disease Therapeutic strategies therapeutic strategy
[DOI] 10.18632/aging.202691 PMC 바로가기 [Article Type] Research Paper

Clinical characteristics and peripheral immunocyte subsets alteration of 85 COVID-19 deaths

Research Paper

Published on 2021-03-152022-10-28
Journal: Aging (Albany NY) [Category] COVID-19, SARS,

[키워드] age and gender Analysis B cell C-reactive protein CD4 CD8 Characteristics clinical Clinical characteristics collected COVID-19 COVID-19 patient COX D-dimer death death in COVID-19 demonstrated develop died early stage electronic medical records evaluate groups high risk hospitalized COVID-19 patient identify immunological characteristics increased the risk laboratory data Lymphocyte count Lymphocytes Mortality multiple logistic regression natural killer cell neutrophil neutrophil count NK cells Patient reduce researcher risk factor risk of death SARS-CoV-2 SARS-COV-2 infection severe disease significant decrease significantly higher significantly lower subset T cell T cells Total White blood cell Wuhan, China
[DOI] 10.18632/aging.202819 PMC 바로가기 [Article Type] Research Paper

Dynamic blood single-cell immune responses in patients with COVID-19

Article

Published on 2021-03-062022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 변종,

[키워드] 2019 coronavirus disease activated addition Analysis B cell B cell receptor BCR Blood caused CD14+ monocytes CD4+ T lymphocyte CD8+ T lymphocytes Cell Biology change Cohort Concentration condition Control controls COVID-19 critical condition DCs dendritic cell dynamic Ferroptosis Gene Expression health emergency IFI27 IFN-I IFN-I pathway IFN-α immune response indicated Infectious diseases Interferon-α investigated MAPK mononuclear cell mRNA mRNA level naïve natural killer cell outbreak Pathogenesis pathway Patient patients with COVID-19 PBMCs Peripheral blood progenitor cell Protein reduction reveal SARS-CoV-2 antigens SARS-COV-2 infection scRNA-seq sequence Sequencing serum significant decrease significantly significantly increased single-cell Stage T cell T cell receptor TCR the disease the SARS-CoV-2 virus therapeutic potential Transcriptome treating COVID-19 type I interferon validation cohort
[DOI] 10.1038/s41392-021-00526-2 PMC 바로가기 [Article Type] Article

Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children

소아에서 SARS-CoV-2 감염의 급성 및 회복기 동안의 타고난 세포 프로필

Article

Published on 2021-02-172022-09-10
Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단,

[키워드] activated neutrophil Activated neutrophils acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD63 cell profile children circulating classical clinically convalescent convalescent phase coronavirus Course COVID-19 dendritic cell dendritic cells disease immune responses immunological immunological mechanism Immunopathogenesis infected children Infection Infectious diseases Innate innate immune response innate immune system Innate immunity low-density Mild mild SARS-CoV-2 infection monocyte Monocytes natural killer cell Natural killer cells neutrophil Neutrophils non-classical monocyte Non-classical monocytes observé PCR testing proportion reduced respiratory SARS-CoV-2 SARS-COV-2 infection subset
[DOI] 10.1038/s41467-021-21414-x PMC 바로가기 [Article Type] Article

Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) Pathophysiology

Review

Published on 2021-02-052022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] activate Activation acute respiratory syndrome age alteration antiviral response aryl Aryl hydrocarbon receptor Butyrate CD8+ T cells circulating condition conditions Coronavirus-2 COVID-19 COVID-19 pandemic diabete driven by dysregulated Effect EGCG expression level gallate Gut high risk hydrocarbon immune cells immune response Implications increase in increased risk indole Infection inhibit initial LPS macrophages Mast cells melatonin metabolism Mitochondrial function natural killer cell Neutrophils nutraceutical obesity physiological pro-inflammatory cytokine pyruvate Regulation Research respiratory response resveratrol SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome suppresse Treatment Tryptophan
[DOI] 10.3390/ijms22041597 PMC 바로가기 [Article Type] Review

Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients

Letter to the Editor

Published on 2021-01-272022-10-31
Journal: Experimental Hematology & Oncology [Category] COVID-19,

[키워드] acute respiratory syndrome Admission Antibody Response B cell basophil caused cell count cells clearance Cohort coronavirus Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patient COVID-19 patients criteria CRP discharge first positive IgG antibody IgM/ IgG antibody IgM/IgG IL-6 Infection Inflammation innate immune cell Killer cell Lymphocyte count Lymphocyte subset Lymphocytes lymphocytopenia Mortality Nasopharyngeal swab natural natural killer cell Neutrophils NK cell non-severe group oropharyngeal swabs parameter Patient Peripheral blood platelets counts respiratory symptom RNA viral shedding SARS-CoV-2 SARS-CoV-2 viral RNA serum cytokine severe group significant difference significantly significantly lower specimens survival rate T cells therapy Treatment upper respiratory tract viral disease Viral RNA viral shedding White blood cells
[DOI] 10.1186/s40164-021-00199-1 PMC 바로가기 [Article Type] Letter to the Editor

Establishment of an African green monkey model for COVID-19 and protection against re-infection

코로나19 아프리카 녹색원숭이 모델 구축 및 재감염 방지

Article

Published on 2021-01-012022-09-11
Journal: Nature Immunology [Category] Fulltext, SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African green monkey African green monkeys AGM AGMs animal animal models antibody Antibody titer Antibody titers Blood bronchoalveolar lavage sample bronchoalveolar lavage samples Cell cellular response Cellular responses clearance Coagulopathy contributed coronavirus COVID-19 COVID-19 case COVID-19 pathogenesis demonstrated develop Features global pandemic green green monkeys Inflammation interferon interleukin interleukin-6 Medical countermeasures mucosal natural killer natural killer cell natural killer cell- Pathogenesis pathogenesis of COVID-19 pathway Peripheral blood Re-infection Rectal swabs repression respiratory Respiratory disease responsible robust SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stimulation Support T cell These data tissue tissues transcript Transcriptome transcriptome analysis utility Vaccine
[DOI] 10.1038/s41590-020-00835-8 PMC 바로가기 [Article Type] Article

COVID-19’s toll on the elderly and those with diabetes mellitus – Is vitamin B12 deficiency an accomplice?

Research article

Published on 2021-01-012022-10-05
Journal: Medical Hypotheses [Category] SARS, 신약개발,

[키워드] ACEangiotensin-converting enzyme alanine aminotransferase ALTalanine aminotransferase Angiotensin-converting enzyme B12 B12Vitamin B12 BMIbody mass index body mass index C-reactive protein Case fatality rate CD4+T helper cells CD8+Cytotoxic T cells CFRCase fatality rate CIconfidence intervals complications Confidence intervals Coronavirus disease caused by SARS-CoV-2 costly COVID-19 COVID-19Coronavirus disease caused by SARS-CoV-2 CRPC-reactive protein Cytotoxic T cells deficiency diabetes Diabetes Mellitus DiabetesDiabetes mellitus eGFRestimated glomerular filtration rate Endothelial cell estimated glomerular filtration rate Evidence fatality HCVHepatitis C virus help hepatitis C virus hospitalisation Hypothesis identify IFN-γInterferon gamma ILInterleukin intensive care interferon gamma interleukin Internal ribosomal entry site for the hepatitis C virus IRESInternal ribosomal entry site for the hepatitis C virus nation National Health And Nutrition Examination Survey natural killer cell NHANESNational Health And Nutrition Examination Survey NK cellNatural killer cell Non-structural protein of SARS-CoV-2 nspNon-structural protein of SARS-CoV-2 Odds ratio OROdds Ratio outcome Patient question risk factor Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SDStandard deviation severe acute respiratory syndrome coronavirus 2 significantly SOCStandard of care Standard deviation Standard of care Sustained viral response SVRSustained viral response T helper cells T2DMType-2 diabetes mellitus TNF-αTumour necrosis factor alpha Tumour necrosis factor alpha Type-2 diabetes mellitus UMFAUnmetabolized folic acid Unmetabolized folic acid Vaccine vitamin B12
[DOI] 10.1016/j.mehy.2020.110374 [Article Type] Research article