A Confirmed Case of SARS-CoV-2 Pneumonia With Negative Routine Reverse Transcriptase-Polymerase Chain Reaction and Virus Variation in Guangzhou, China중국 광저우에서 일상적인 역전사효소-중합효소 연쇄반응과 바이러스 변이를 동반한 SARS-CoV-2 폐렴의 확인된 사례Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody detection chain Chain Reaction Clinical diagnosis Confirmed coronavirus diagnosed Diagnosis disease effective false-negative false-negative results Guangzhou, China Nanopore nanopore sequencing negative ORF pathogen Pneumonia reaction reverse transcriptase routine routine RT-PCR RT-PCR RT-PCR diagnosis SARS-CoV-2 SARS-CoV-2 pneumonia Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcriptase Variation virus virus variation [DOI] 10.1093/cid/ciaa941 PMC 바로가기 [Article Type] Article
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern에피토프 특이적 항체 반응으로 COVID-19 결과와 우려 변종 차별화Clinical Medicine Published on 2021-07-082022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료법, [키워드] Action antibody antibody profiling Antibody Response Antibody responses Antibody testing Antigen antigens B.1.1.7 Clinical outcome Clinical severity complex complexity coronavirus COVID-19 detect develop epitope epitope peptide Epitopes foundation Health Sciences high resolution High-resolution Humoral immunity identify immunoassay immunoglobulins Infection Infectious disease Innovation linear epitope linear epitopes London Microarrays Mutation N protein Neutralizing Neutralizing antibodies Non-neutralizing antibodies nucleocapsid ORF organization outcome P681H patient survival peptide peptides plasma sample plasma samples positively correlated predict produced Protein Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome Science screened serology test serology tests specificity the SARS-CoV-2 Toronto university variant variants variants of concern [DOI] 10.1172/jci.insight.148855 PMC 바로가기 [Article Type] Clinical Medicine
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 PatientsResearch Article Published on 2021-06-292022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants [DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article
Detection of SARs-CoV-2 in wastewater using the existing environmental surveillance network: A potential supplementary system for monitoring COVID-19 transmissionResearch Article Published on 2021-06-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] can be used caused circulation close contact collected Concentration COVID 19 COVID 19 patient COVID-19 COVID-19 pandemic COVID-19 testing COVID-19 transmission Cq value decrease detection development environmental condition facilitate facilitated Faeces high-speed centrifugation indicate Infection introduced MONITOR ORF Patient polio positive positive sample Probability quarantine resulting RNA RNA extraction RT-qPCR SARS-CoV-2 sensitivity sequence Surveillance surveillance network tested Transmission transmitted Viral RNA virus [DOI] 10.1371/journal.pone.0249568 PMC 바로가기 [Article Type] Research Article
The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2SARS-CoV-2에서 병원체 관련 CpG 디뉴클레오티드의 이질적 풍경과 초기 진화Discoveries Published on 2021-06-082022-09-10 Journal: Molecular Biology and Evolution [Category] SARS, 치료법, [키워드] 3′UTR acting acute respiratory syndrome Amino acid Antiviral antiviral protein binding pattern binding patterns circulating coding region comparable COVID-19 COVID-19 pandemic CpG CpG motifs cytoplasm dinucleotide dinucleotides distribution dual dysregulated Evolution evolution of synonymous mutations expressed Genome greater HKU1 human host immune infected cell infected cells landscape lead loci MERS motif Mutation ORF outbreak pathogen-associated molecular pathogen-associated molecular patterns pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors pressure Protein Region Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 genome Sequence motifs Signaling signature ssRNA viruses statistical synonymous the SARS-CoV-2 genome transcript transversion triggering Viral viral host mimicry Zinc zinc finger antiviral protein [DOI] 10.1093/molbev/msab036 PMC 바로가기 [Article Type] Discoveries
In Silico and In Vitro Analyses Validate Human MicroRNAs Targeting the SARS-CoV-2 3′-UTRArticle Published on 2021-06-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 3′-UTR Analysis Antiviral antiviral defense assays Betacoronavirus bioinformatics candidate Candidates carried caused cellular complementary composed COVID-19 COVID-19 pandemic Defense effective functions gene reporter Genome host cell hsa-miR-138-5p hsa-miR-3941 Human identify in vitro indicate information microRNA MicroRNAs modulate mRNAs Open Science Framework ORF protective effect protein expression Repository Result RNA SARS-CoV-2 SARS-CoV-2 3′-UTR SARS-CoV-2 genome target mRNA targeting the SARS-CoV-2 Therapeutic treatment variant virus [DOI] 10.3390/ijms22116094 PMC 바로가기 [Article Type] Article
Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clustersCOVID-19 패밀리 클러스터로부터 분리 된 SARS-COV-2의 분자 역학Research Published on 2021-06-012022-09-01 Journal: BMC Medical Genomics [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Amino acid Analysis change clade Cluster Clusters collected Combination COVID-19 COVID-19 severity D614G D614G mutation dataset Deceased disease epidemiological data Epidemiology Families family Family cluster Frame Genome highlight Illumina Miseq Indonesia Infection involved Multiple spike protein mutations Mutation mutations next-generation sequencer nucleic acid Open reading frame ORF outcomes Patient patients patients with COVID-19 Phylogenetic analysis Protein Q677H regions Result resulting SARS-CoV-2 SARS-CoV-2 transmission sequence sequences SNP Spike protein supplementary material survived transmission of SARS-CoV-2 virus virus sample virus samples viruses was performed Whole genome sequencing [DOI] 10.1186/s12920-021-00990-3 PMC 바로가기 [Article Type] Research
Proliferation of SARS-CoV-2 B.1.1.7 Variant in Pakistan-A Short Surveillance AccountSARS-CoV-2 B.1.1.7 파키스탄-A 단기 감시 계정의 변종 확산Public Health Published on 2021-05-312022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] A570D affecting amplification B.1.1.7 B.1.1.7 variant B1.1.7 characteristic circulation country COVID-19 diagnostics followed by Frequency Genome genomic implementation implication increase in initial screening Laboratory low frequency measure Mutation N501Y ORF P681H Pakistan public health raised reported RT-PCR kit SARS-CoV-2 SARS-CoV-2 B.1.1.7 Sequencing spike gene subset Surveillance T716I TaqPath tested the Spike ThermoFisher Scientific United Kingdom upsurge variant of SARS-CoV-2 virus transmissibility VoC whole-genome sequencing [DOI] 10.3389/fpubh.2021.683378 PMC 바로가기 [Article Type] Public Health
An Intramuscular DNA Vaccine for SARS-CoV-2 Decreases Viral Lung Load but Not Lung Pathology in Syrian HamstersArticle Published on 2021-05-122022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 2019 novel coronavirus administration Antibody Response Antibody titer Combination controls decrease DNA DNA vaccine effective interventions Efficacy evaluated Frame full length hamster host cell in vivo induce Infectious virus intramuscular intranasal load lung Lung pathology ORF pathology Prevent protective immune response public health receiving reducing reported Safe SARS-CoV-2 Spike protein syrian hamster model tested the SARS-CoV-2 vaccination Vaccine vaccine candidate Vaccines Viral load viral loads virus titer [DOI] 10.3390/microorganisms9051040 PMC 바로가기 [Article Type] Article
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes44개의 Sarbecovirus 게놈을 비교하여 SARS-CoV-2 유전자 함량 및 COVID-19 돌연변이 영향Comparative Study Published on 2021-05-112022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Analysis annotation B-cell epitope Cluster Comparative genomics conservation conserved contribute COVID-19 COVID-19 pandemic D614G Dissection E484K epitope evidence of Evolution except for experimental evidence functional mutation functional mutations Genome individual lack molecular evolution Mutation mutations N501Y Nsp3 nucleocapsid nucleotide ORF ORF3c ORF8 ORFs overlapping predicted protein-coding gene provide reported residue residues SARS-CoV-2 SARS-CoV-2 biology Sequence annotation spike-protein strain Substitution the SARS-CoV-2 Transmission valuable resource [DOI] 10.1038/s41467-021-22905-7 PMC 바로가기 [Article Type] Comparative Study