phenotypic – Page 5 – Communicable Diseases Research

Immune targets for therapeutic development in depression: towards precision medicine

Reviews

Published on 2022-01-172022-10-05
Journal: Nature Reviews Drug Discovery [Category] Coronavirus, 바이오마커, 유전자 메커니즘, 진단,

Paternally expressed gene 3 ( Pw1/Peg3 ) promotes sexual dimorphism in metabolism and behavior

친밀하게 발현 된 유전자 3 (PW1/PEG3)은 신진 대사와 행동에서 성 이형성을 촉진합니다

Research Article

Published on 2022-01-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accelerated Adiposity adulthood age allele alteration Behavior Brain Cell cells Characteristics consequence contribute develop Diabetic Endocrine Epigenetic examined expressed expressing fat accumulation Fatty liver female genomic genomic imprinting gonadal growth hormone insulin insulin resistance life loss of function male mammal mammals manifested masculinization metabolism mice mutant observation parental pathway Peg3 phenotypic postnatal development proliferative promote provide puberty question reduced Regulation selective Sex sex steroid sexual dimorphism Signaling steroid Support tissues weaning
[DOI] 10.1371/journal.pgen.1010003 PMC 바로가기 [Article Type] Research Article

Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19

Research Article

Published on 2022-01-102022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility
[DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article

BioSamples database: FAIRer samples metadata to accelerate research data management

BioSamples 데이터베이스: FAIRer는 메타데이터를 샘플링하여 연구 데이터 관리를 가속화합니다.

AcademicSubjects/SCI00010

Published on 2022-01-072022-09-10
Journal: Nucleic Acids Research [Category] 유전자 메커니즘,

[키워드] accelerate Alliance benefit Community complex connection content contribute COVID-19 research data management Data quality database described feature Genomics genotypic heterogeneous highlight IMPROVE improvement information Institutional Repository manuscript Metadata phenotypic phenotypic information Repository Research resources resulting submission Support term use cases
[DOI] 10.1093/nar/gkab1046 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

COVID-19 transmission dynamics underlying epidemic waves in Kenya

케냐의 전염병 파도의 기본 전염성 역학

Article

Published on 2022-01-072022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종,

Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor

Article

Published on 2022-01-062022-10-04
Journal: Communications Biology [Category] SARS, 변종,

[키워드] ACE2 receptor acute respiratory syndrome addition African amino acid substitution Analysis antigenicity binding characteristic complex complexes contagiousness coronavirus Effect English feature greater help human ACE2 receptor Interaction molecular Molecular conformation Molecular dynamics simulation Molecular modelling MONITOR Mutation negative control no effect observation occur pandemic performed phenotype phenotypic provoke residue SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant selected selective several variant South specific mutation spike variant spike variants Spread stability stabilizing effect Surveillance the SARS-CoV-2 the spike protein variant variants Variation viral genome virus while wild type
[DOI] 10.1038/s42003-021-02946-w PMC 바로가기 [Article Type] Article

Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway Axis

SARS-CoV-2 감염 후 심혈관 위험은 IL18/IL18R1/HIF-1 신호 경로 축에 의해 매개됩니다

Immunology

Published on 2022-01-052022-09-11
Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, 치료제,

[키워드] activate activated Activation Algorithm Analysis Aneurysm aneurysms Atherosclerosis axis cardiovascular cardiovascular risk Cell cell types changes in characterized choice Compound COVID-19 COVID-19 infection detect Epigenetic expected functional gene co-expression network HIF-1 HIF-1 signaling pathway HIF1a hypoxia identify IL-18 IL18 IL18R1 Infection Inference Intercellular communication interleukin locus Macrophage macrophages MAP2K1 mechanism Mediated MEK inhibitor Methylation NF-κB nucleus objective pathway Pathways PBMC phenotype phenotypic Potential promote promoted Proteins Proteomic analysis Regulation Regulatory Regulon Result SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling signaling pathway smooth muscle therapeutic compound therapeutic target Treatment type I interferon type I interferon pathway vascular smooth muscle vascular smooth muscle cells VIPER was used WGCNA with COVID-19
[DOI] 10.3389/fimmu.2021.780804 PMC 바로가기 [Article Type] Immunology

Non-invasive Respiratory Support in COVID-19: A Narrative Review

Medicine

Published on 2022-01-042022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Exploring AyuGenomics approach for understanding COVID-19 predisposition and progression

Review article

Published on 2022-01-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발, 유전자 메커니즘,

Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 Study

Protocol

Published on 2021-12-162022-10-04
Journal: International Journal of Environmental Research an [Category] SARS, 임상,

[키워드] activity Adipose tissue analyzed approach baseline Biochemistry Blood blood sample body composition clinical collected conducted Control coronavirus coronavirus disease COVID-19 cytokine profile determine Effect evaluated Evidence exercise Exercise capacity explain expressed function functional healthy help homologous immune Immunity immunomodulatory in-vitro assay inactive individual Infection Inflammation Inflammatory information innate immune system knowledge Level long-COVID mechanism Mental mental health metabolic parameters metabolism Mild Moderate COVID-19 mononuclear cell obese participant Patient patients with COVID-19 PBMC PBMCs peripheral phenotypic physical physical activity physical activity level physically positive procedure Prospective prospective observational cohort provided Pulmonary function registry repeated-measures ANOVA Respiratory muscle strength respond response SARS-CoV-2 SARS-COV-2 infection Seahorse serum stimulated survival the SARS-CoV-2 virus the vaccine Trajectories treated vaccination venous viral infection virus
[DOI] 10.3390/ijerph182413249 PMC 바로가기 [Article Type] Protocol