Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article
Regulation of Stress Responses and Translational Control by CoronavirusReview Published on 2016-07-042022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association cellular stress response Control coronavirus Coronavirus infection Coronavirus replication eIF2α Endoplasmic reticulum ER stress GADD34/PP1 host cells in viral JNK mechanism modulate nsp1 overcome p38 Pathogenesis Pathways PERK PKR Protein protein synthesis protein translation reduce response responses Stress translational translational control Trigger turn unfolded protein response Viral protein viruses [DOI] 10.3390/v8070184 PMC 바로가기 [Article Type] Review
Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactionsArticle Published on 2014-10-072022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activating Activation anti-apoptotic Apoptosis Apoptotic cell death ATF6 autophagy cause Cell coronavirus Coronavirus infection coronavirus protein cross-talk Degradation disturbance Endoplasmic reticulum ER stress eukaryotic cells Evidence facilitate homeostasis induce infected cells innate immune response Innate immunity Interaction involved knowledge Modification modulate occur pathological conditions pathway Pathways physiological pro-apoptotic pro-inflammatory cytokines pro-inflammatory response Protein protein synthesis Regulation Replication shown signaling pathway signaling pathways transcriptional translation transmembrane unfolded protein response UPR [DOI] 10.1016/j.virusres.2014.09.016 PMC 바로가기 [Article Type] Article
A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific AbortifacientsRNA-seq 분석을 통해 태생 곤충에서 식별된 매우 다양한 새로운 단백질 패밀리: 체체 파리 관련 낙태 환자의 잠재적 표적Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abortifacient addition African Amino acid amino acid sequence Analysis approaches casein cattle causative agents characterization coding control mechanisms Critical Differential analysis enrichment Factor family fecundity female functional genes encoding Genome genomic homeostasis Human Identified identify indicate insect Interference knockdown lactating lactation lipid metabolism maintenance mammalian mechanism mechanisms metabolism mother s milk novel occur organized Potential progeny Protein protein level protein synthesis Proteins proteome provided reduce reduced reducing Region reproductive resource RNA-Seq RNA-seq data secretion sequence similarity Seven shown similarities sleeping sickness specificity suppression synthesis target to define transcript Transcriptome transcripts Transferrin tsetse tsetse flies tsetse fly unique variant Viviparous were expressed while [DOI] 10.1371/journal.pgen.1003874 PMC 바로가기 [Article Type] Research Article
The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transportResearch Published on 2014-04-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] absence accumulated acute respiratory syndrome Apoptosis Aprotinin association Brefeldin A carried Cell coronavirus Degradation detect distribution expressed function Golgi immunofluorescence Increased induce lipid droplets lysosomal marker motif mRNA mutant Mutation plasma membrane Protein protein level protein synthesis Proteins residue Result reversed RT-PCR SARS Coronavirus SARS-CoV significantly lower staining subcellular distribution Transcription transfected with translation Transport transported tyrosine viral pathogenesis was performed while wild type [DOI] 10.1186/1743-422X-11-75 PMC 바로가기 [Article Type] Research
Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replicationMicrobiology Published on 2014-01-092022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] Chlamydia pecorum absence Alter aminopeptidase N binding CD13 Cell cellular signaling pathway characteristic Chlamydia Chlamydiae chlamydial persistence chlamydial stress response chronic inflammation Co-infection contribute Course Critical Culture cycloheximide de novo demonstrated developmental disease drug epidemic diarrhea experiment Host host cell receptor incubated indicated induce Infected Infection infectious inhibit inhibited non-infectious PEDV performed persistence Porcine epidemic diarrhea virus produced protein synthesis reduced removed Replication replicative required stimulate stressed chlamydiae Vero Cell Viral protein viral replication virus [DOI] 10.3389/fcimb.2014.00020 PMC 바로가기 [Article Type] Microbiology
Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan‐mediated antibiotic resistance아미노아실화된 전이 RNA의 방향은 항생제 합성 및 펩티도글리칸 매개 항생제 저항에 관여한다.journal-article Published on 2013-09-172024-08-04 Journal: FEBS Letters [Category] 폐렴구균 감염증, [키워드] antibiotic Antibiotic resistance Pathogenesis peptidoglycan protein synthesis translation tRNA [DOI] 10.1016/j.febslet.2013.07.036 [Article Type] journal-article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolaseResearch Published on 2010-02-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated Activation Amino acid Apoptosis cell proliferation cellular co-immunoprecipitation culture cell cytoplasm DNA repair DNA replication ENCODE expressing Frame Host Human human cell interact Interaction involved nucleotide ORF pathogenic processe Protein protein synthesis Proteins Regulation responsible RNA SARS Coronavirus SARS-CoV sequence homology shown tissue virus yeast [DOI] 10.1186/1743-422X-7-31 PMC 바로가기 [Article Type] Research