SARS-CoV-2 S1 is superior to the RBD as a COVID-19 subunit vaccine antigenSARS-CoV-2 S1은 COVID-19 소단위 백신 항원으로서 RBD보다 우수합니다.Article Published on 2021-02-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome adjuvant antibody Antibody-dependent enhancement Antigen combating coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines Critical effective epitope Epitopes expression global pandemic IgA IgG immunized indicate Infection maintain mice Modification much higher neutralization neutralized potential risk proportion RBD Receptor-binding domain Recombinant spike protein reduce S1 S1 domain SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 subunit vaccine Spike protein subunit Subunit vaccine Th1 response the RBD the receptor-binding domain vaccine antigen while [DOI] 10.1002/jmv.26320 PMC 바로가기 [Article Type] Article
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidatesCOVID-19 회복기 혈장 기증자 후보 중 SARS-CoV-2에 대한 중화 항체의 임상, 실험실 및 시간 예측인자Clinical Trial Published on 2021-02-012022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단, [키워드] 95% CI adaptive Adaptive immunity adjusted administration of plasma age Analysis antibody AOR assays candidate clinical collected convalescent individual convalescent plasma correlated COVID-19 Cutoff declined disease disease severity Donor Factor Fever Frederick Hospitalization immune immunoglobulins individual Infectious disease Laboratory laboratory assay Male sex median NAb neutralizing antibody New NIAID NIH Older age plasma Predictive predictor proportion PROTECT receiver operating characteristic Reinfection responses S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-neutralizing antibody seronegative seropositive serum IgG severity Sex Society specimen Streamline Support supported symptom onset T cell tested transplantation treatment for COVID-19 Virology with COVID-19 [DOI] 10.1172/JCI144930 PMC 바로가기 [Article Type] Clinical Trial
Structural Comparison of the SARS CoV 2 Spike Protein Relative to Other Human-Infecting CoronavirusesMedicine Published on 2021-01-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] approach C-terminal domain (CTD) Cluster Contact CoV CoV spike protein CoV spike proteins CoVs generate HCoV 229E HKU1 Host Human Infection Lineage MERS Model modeling N-terminal domain (NTD) NL63 OC43 Other pandemic pattern performed Phylogenetic Protein relative RMSD RNA virus S1 domain S1-NTD SARS coronavirus 2 (SARS2) SARS CoV SARS1 SARS2 selected Seven similarity spike spike glycoprotein Spike protein viral pathogenesis viral surface virulence whole protein [DOI] 10.3389/fmed.2020.594439 PMC 바로가기 [Article Type] Medicine
COVID-19 variants that escape vaccine immunity: Global and Indian context-are more vaccines needed?백신 면역을 벗어나는 COVID-19 변종: 전 세계 및 인도 상황에서 더 많은 백신이 필요합니까?Review Published on 2021-01-012022-09-11 Journal: Journal of biosciences [Category] MERS, 변종, 진단, [키워드] ACE2 receptor Antigen bind Cell claimed complex convalescent plasma COVID-19 COVID-19 pandemic cryo-EM structure docked Efficacy Evolution exhibited followed by furin furin cleavage site Infection junction Mutation N terminal domain Neutralizing NTD occur proline RBM receptor binding motif residue responsible RNA virus S protein S1 domain S1 subunit S2 subunit SARS-CoV-2 selection pressure subunit the S1 subunit Vaccine vaccine candidate Vaccine development variant variants Viral viral envelope was used Wuhan [DOI] 10.1007/s12038-021-00226-7 PMC 바로가기 [Article Type] Review
Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus InfectivityMicrobiology Published on 2020-11-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 5′ UTR acute respiratory syndrome Amplicon sequencing Analysis Asia caused clade Concordance coronavirus Coronavirus disease 2019 COVID-19 D614G D614G mutation disease transmission docking Europe Evolution FIVE Genome global pandemic Gujarat hinge region increase India Infectivity Local molecular Mutation network analysis ORF1ab gene Phylogeny Prevalence prevalent Protein protein-protein interaction reported S1 domain SARS-CoV-2 SARS-CoV-2 genome sequenced genome spike the disease the Spike TMPRSS2 TMPRSS2 protease Transmission Viral load viral RNA sequencing virus [DOI] 10.3389/fmicb.2020.594928 PMC 바로가기 [Article Type] Microbiology
Static all-atom energetic mappings of the SARS-Cov-2 spike protein and dynamic stability analysis of “Up” versus “Down” protomer statesResearch Article Published on 2020-11-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] ACE-2 receptor acting Amino acid Analysis backbone atom binding characteristic conducted conserved COVID-19 Critical cross demonstrated determine disrupting distal domain dominant example experimental structure human epithelial cells inactive include independent Interaction interactions intrachain involved Molecular dynamics simulation Mutation NTD pandemic performed Point mutation prefusion Protein provided proximal RBD Receptor binding domain reduced reported residue responsible S1 domain SARS-CoV-2 sequence spike Spike protein stability Static the RBD the SARS-CoV-2 trimeric turn Van der Waals Variation virion virus [DOI] 10.1371/journal.pone.0241168 PMC 바로가기 [Article Type] Research Article
Seroprevalence of SARS-CoV-2 IgG Antibodies in Corsica (France), April and June 2020Article Published on 2020-11-052022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome adjusted age Analysis anti-SARS-CoV-2 antibodies Blood borderline collected conducted Coronavirus-2 Corsica COVID-19 ELISA enzyme Euroimmun France French group groups highest IgG IgG antibody immunoassay Immunoglobulin G Infection lockdown Neutralizing antibody titer P -value pandemic Patient positive sample Prevalence Region reported residual S1 domain SARS-CoV-2 SARS-CoV-2 IgG sera seroneutralization Seroprevalence Sex significant difference tested viral spike protein virus neutralization test VNT [DOI] 10.3390/jcm9113569 PMC 바로가기 [Article Type] Article
A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infectionchilblain-like 병변을 가진 19명의 연속 이탈리아 소아 환자에 대한 임상, 조직 병리학 및 실험실 연구: COVID-19 감염과의 관계에 대한 빛과 그림자Article Published on 2020-11-012022-09-11 Journal: Journal of the European Academy of Dermatology and [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] Acral anomalies Autoimmune disease Autoimmune diseases basal layer Blood borderline Capillaries Characteristics chilblain children clinical evaluation Coagulation COVID-19 COVID-19 infection COVID-19 pandemic dermis direct immunofluorescence electron microscopy epidermal finger flu-like symptom flu-like symptoms heel histopathological Histopathology hypodermis IgA IgG immunofluorescence increasingly Infection Informed consent Italian Laboratory lesion lesions Major majority mechanism Microscopy mucin Nasopharyngeal swab nucleocapsid protein oedema paediatric patient papillary dermis Pathogenesis pathological finding Patient patients perivascular positive Protein recruited reported RT-PCR S1 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein selected serology serology testing skin lesion skin lesions skin manifestation Spike protein Swab thrombi vessel with COVID-19 [DOI] 10.1111/jdv.16682 PMC 바로가기 [Article Type] Article
CoVaccine HT™ Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 ImmunizationCoVaccine HT™ 보조제는 재조합 SARS-CoV-2 스파이크 S1 면역화에 대한 강력한 면역 반응을 강화합니다Immunology Published on 2020-10-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] addition adjuvant Affinity maturation Cell-mediated immunity claimed Combination contagious COVID-19 COVID-19 pandemic develop Efficacy elicited facilitated global effort greater IgG immunogenicity induce neutralizing antibody titres Protective protective immune response Protein protein subunit vaccine rapid response recombinant recombinant subunit respiratory virus response S1 domain SARS-CoV-2 SARS-CoV-2 vaccine single dose spike switching titre Vaccine virus [DOI] 10.3389/fimmu.2020.599587 PMC 바로가기 [Article Type] Immunology
Antibody-mediated disruption of the SARS-CoV-2 spike glycoproteinArticle Published on 2020-10-212022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] antibody Antibody binding binding convalescent SARS patient CR3022 cross-react Cryo-electron microscopy Cryoelectron microscopy ectodomain examined Fab monoclonal antibody neutralisation neutralising S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike trimer selected spike glycoprotein the SARS-CoV-2 [DOI] 10.1038/s41467-020-19146-5 PMC 바로가기 [Article Type] Article