Identification of a guanine-specific pocket in the protein N of SARS-CoV-2SARS-CoV-2의 단백질 N에서 구아닌 특이적 포켓 식별Article Published on 2022-07-162022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] addition binding biochemical C-terminal domain complex conformation conserved Coronaviruses crystal structure CTD EMSA facilitate GTP guanine identification inhibitors Interaction mutant N protein nucleotide oligonucleotide Packaging sequence Protein Region residue responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid sequence specificity the N protein Tryptophan [DOI] 10.1038/s42003-022-03647-8 PMC 바로가기 [Article Type] Article
Seroprevalence and dynamics of anti-SARS-CoV-2 antibodies: a longitudinal study based on patients with underlying diseases in Wuhan항-SARS-CoV-2 항체의 혈청유병률 및 역학: 우한의 기저 질환 환자를 기반으로 한 종단 연구Article Published on 2022-07-152022-09-11 Journal: Respiratory Research [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI All participant All participants anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Assessing asymptomatic patient asymptomatic patients baseline Blood blood sample Blood samples change Community COVID-19 Diseases door effective family members feature Follow-up Government healthcare Households Humoral immunity IgA IgG IgG antibodies IgG antibody IgG titer IgG titers IgM immunoglobulins individual infected with SARS-CoV-2 list Local local government natural infection Neutralising Antibodies neutralising antibody Neutralizing antibody titer no significant difference nucleocapsid protein participant Participants Patient positive Prevention and control Protein provided questionnaire Randomly remained Research SARS-CoV-2 SARS-CoV-2 nucleocapsid selected serological Seroprevalence serum sample serum samples significantly Single natural infection symptomatic patient Symptomatic patients telephone tested titer total antibodies total antibody underlying disease underlying diseases venous venous blood was collected were assessed Wuhan [DOI] 10.1186/s12931-022-02096-5 PMC 바로가기 [Article Type] Article
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome항뉴클레오캡시드 항체 수준 및 폐 동반질환 상태는 코로나19 이후 증후군과 관련이 있습니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] age allergy antibody Antigen Asthma Asymptomatic Biohub Biomarker Biomarkers blood draw blood draws center Cohort comorbid condition COVID-19 disease COVID-19 disease severity COVID-19 infections Critical CTSA Diagnosis disease disease severity Ethnic groups Ethnicity Factor foundation IgG IgG response immunoglobulins in-person visit Infectious disease initial initiative Lung disease median time nasal swab NIH not affect nucleocapsid IgG participant Patient PCR test PCR-positive positive RT-PCR ranged recruited Remdesivir reported reverse transcription risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Sean Sex Stanford Stanford University Study participants sustained Symptom symptom resolution Symptoms syndrome with COVID-19 [DOI] 10.1172/jci.insight.156713 PMC 바로가기 [Article Type] Article
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses치명적인 COVID-19 결과는 풍토성 코로나바이러스와 공유되는 에피토프를 표적으로 하는 항체 반응과 관련이 있습니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Adaptive immunity antibody Antibody Response Antibody responses antigenic beta-coronavirus characteristic conservation coronavirus coronavirus disease Coronavirus disease 2019 correlated strongly correlation COVID-19 cross-reactive disease Disease progression domain Endemic epitope Epitopes fatal COVID-19 full-length spike protein highest ICU immune response immune responses immunology Imprinting individual Infection Infectious disease intensive care intensive care unit less magnitude not significantly different nucleocapsid outcome outcomes proportion Protective Region respiratory Respiratory Coronavirus response S2 subunit SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein severe acute respiratory coronavirus Spike protein Spike proteins subunits the antibody response the SARS-CoV-2 variable regions [DOI] 10.1172/jci.insight.156372 PMC 바로가기 [Article Type] Article
Case of adult-onset Kawasaki disease and multisystem inflammatory syndrome following SARS-CoV-2 vaccinationSARS-CoV-2 예방접종 후 성인 발병 가와사키병 및 다기관 염증 증후군 증례Case Reports Published on 2022-07-042022-09-11 Journal: BMJ case reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] absence Adult patients Adverse reactions antibodies antibody children condition COVID-19 criteria demonstrated desquamation dose Effect hands Immunoglobulin immunological products and vaccines infection with SARS-CoV-2 Inflammatory Intervention Intravenous immunoglobulin Kawasaki disease limit MIS occur Patient postvaccination recent reverse transcriptase reverse transcriptase PCR rheumatology SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine Spike protein syndrome tested Treatment Unwanted effects / adverse reactions vaccination Vaccination/immunisation vaccine response widespread [DOI] 10.1136/bcr-2022-249094 PMC 바로가기 [Article Type] Case Reports
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA EncounteringNMR은 RNA 조우에 관여하는 SARS-CoV-2 뉴클레오캡시드 단백질의 본질적으로 무질서한 영역 내의 특정 경로를 나타냅니다Article Published on 2022-07-022022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence atomic binding domain concert COVID-19 Disordered domain engage event experiments genomic RNA identify IDP information Interaction intrinsically N-terminal NMR NMR spectroscopy NTD organized primary sequence priming Protein Region Regulatory RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA Specific the SARS-CoV-2 tract Transcription [DOI] 10.3390/biom12070929 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA detection in Formalin-Fixed Paraffin-Embedded (FFPE) tissue by droplet digital PCR (ddPCR)물방울 디지털 PCR(ddPCR)에 의한 포르말린 고정 파라핀 포매(FFPE) 조직에서 SARS-CoV-2 RNA 검출Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] amplified Atypical Bio-rad cause clinical utility clinically COVID-19 digital PCR droplet droplet digital PCR extraction fetal FFPE formalin formalin-fixed paraffin-embedded highest Infection limit of detection liver liver transplant liver transplant rejection material paraffin Placenta Placental viral infection positive positive sample Pregnancy qualitative test quantified rejection reported Respiratory disease reverse transcription RNA virus RPP30 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA detection sequence specimen specimens tested tissue Tissue-based viral detection total RNA transplant rejection Viral detection Viral detection in FFPE. viral infection [DOI] 10.1016/j.cca.2022.05.007 PMC 바로가기 [Article Type] Article
The utility of SARS-CoV-2 nucleocapsid protein in laboratory diagnosis실험실 진단에서 SARS-CoV-2 뉴클레오캡시드 단백질의 유용성Review Published on 2022-07-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen antigen detection caused contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnosing Diagnosis Factors global pandemic immunoassay Laboratory laboratory diagnosis matter N antigen nucleocapsid protein patients with COVID-19 Protein respiratory SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid sensitivity severe acute respiratory syndrome Coronavirus specificity suggested Transmissibility uninfected utility Viral Web of Science were assessed were used [DOI] 10.1002/jcla.24534 PMC 바로가기 [Article Type] Review
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations류마티스성 근골격계 질환의 면역억제제 치료는 SARS-CoV-2 감염에 대한 체액 반응의 유발을 억제하지 않고 이펙터 면역 세포 집단을 보존합니다Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] adaptive addition affected Analysis antibody Antibody Response Antibody responses Arthritis B lymphocytes biologic carried Cellular immune response COVID-19 CTLA4 disease disease-modifying anti-rheumatic drug Disease-modifying anti-rheumatic drugs Diseases DMARD drug effector elicit functional humoral Humoral and cellular immune responses immune immune cell populations immune response immune responses immune system immunological Immunosuppressant include individual Inflammatory Inflammatory arthritis inhibitor inhibitors life-threatening Musculoskeletal Neutralizing activity Pathologies Patient patients treated Population presenting provide RBD protein RBD proteins Re-infections response rheumatic musculoskeletal diseases. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid sustained the antibody response TNF-α Treatment virus [DOI] 10.3389/fimmu.2022.873195 PMC 바로가기 [Article Type] Article