Serum Krebs von den Lungen-6 for Predicting the Severity of COVID-19 Lung Injury: A Systematic Review and Meta-AnalysisCovid-19 폐 손상의 중증도 예측을위한 혈청 Krebs von den Lungen-6 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-062022-08-31 Journal: Iranian Biomedical Journal [Category] MERS, 바이오마커, [키워드] 95% CI adult COVID-19 patients alveolar epithelium Analysis appear article Biomarker conducted COVID-19 COVID-19 patient COVID-19 patients eligibility criteria expressed glycoprotein Infectious disease Injury Krebs von den Lungen-6 library Lung injury NOS on type ProQuest reflected review screened sensitivity Sensitivity and specificity serum severe lung injury Severe patient severe patients severity significantly higher SMD specificity systematic review [DOI] 10.52547/ibj.25.6.381 PMC 바로가기 [Article Type] Meta-Analysis
437. Longitudinal Plasma Cytokine Profiles Differentiating COVID-19 Severity GroupsPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome age analyzed assigned association Asymptomatic blood sample cause children Clinical severity cohorts consultant convalescent convalescent plasma coronavirus coronavirus disease COVID-19 criteria CSS cytokine cytokine level cytokine profile Cytokine storm syndrome Disease progression elevated enrolled figure GCSF group hospital Hospitalization Hospitalized IL-10 IL-15 IL-8 Inc Infection Inflammatory Inflammatory response IP-10 Joshua less longitudinal Mild mild cases MIP-1β MIS-C moderate moderate-severe nothing participant Participants Patient PCR Phenotypes plasma sample polymerase chain positive profile Prospective Quantitative response Result SARS-CoV-2 SARS-CoV-2 PCR severe cases severe COVID-19 severe group Severe patient severity Severity Score significant difference syndrome Temporal tested Thomas timepoint timepoints Treatment Wolf [DOI] 10.1093/ofid/ofab466.636 PMC 바로가기 [Article Type] Poster Abstracts
Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19코로나19 진단/예후 바이오마커를 활용한 전문가 모델을 활용한 코로나19 환자의 산화/항산화 수치 예측Article Published on 2021-11-012022-09-11 Journal: International immunopharmacology [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Antioxidant/oxidant parameters ARIMA ARIMA models Biomarker Biomarkers C-Reactive-Protein Care checked coefficient coefficients combating costly COVID-19 COVID-19 (SARS-CoV-2) COVID-19 disease COVID-19 epidemic COVID-19 outbreak COVID-19 patient criteria CRP D-dimer data set diagnosed with COVID-19 Early detection effective error error rate expert Expert systems faster ferritin Forecasting highest infected patient infected patients laboratory parameter lymphocyte no significant difference parameter Patient patients patients with COVID-19 predicted R 2 routine Routine laboratory parameters and biomarkers. Severe patient severe patients significant difference Validity WBC [DOI] 10.1016/j.intimp.2021.108127 PMC 바로가기 [Article Type] Article
Clinical characteristics of COVID-19 in Osaka, Japan: Comparison of the first-third waves with the fourth waveObservational Study Published on 2021-11-012022-10-04 Journal: Respiratory investigation [Category] SARS, 바이오마커, 임상, [키워드] Analysis C-reactive protein cardiovascular cardiovascular disease caused center Characteristics clinical Clinical characteristics Cohort COVID-19 COVID-19 case COVID-19 severity disease disease severity Dyspnea ferritin Fever Fourth wave hospital identify increase in independent risk factor Inflammatory biomarker Japan lactate dehydrogenase median Medical crisis Mild moderate moderate disease Mortality multivariate logistic regression no significant difference organization Osaka Osaka. overall mortality Patient performed resulting Retrospective study risk risk factor severe cases severe COVID-19 severe disease Severe patient transferred worsened [DOI] 10.1016/j.resinv.2021.08.005 PMC 바로가기 [Article Type] Observational Study
Association of Mortality-Related Risk Factors in Patients with COVID-19: A Retrospective Cohort StudyArticle Published on 2021-10-292022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] acute respiratory syndrome Admission age ARDS association cardiac troponin cardiovascular disease Cerebrovascular disease Clinical characteristics Clinical course Clinical outcome cohort study Comorbidities Comorbidity Complication Concentration coronavirus country COVID-19 COVID19 patients dead Deceased defined detect Diabetes Mellitus died discharged disease electronic medical record Epidemiology Factor Fever Follow-up hospital hypertension in-hospital mortality infected patient Infectious disease Inpatient involved Laboratory male manifestation Mortality multivariate logistic regression multivariate regression analysis Non-severe case Older age Patient patients with COVID-19 PCR polymerase chain populations positive COVID-19 potential risk problems provided public health public health measure radiological retrospective risk risk factor risk of death risk-factors SARS-CoV-2 severe complications Severe patient single-center study population Survivors Treatment Viral RNA WHO World Health Organization [DOI] 10.3390/healthcare9111468 PMC 바로가기 [Article Type] Article
Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements질병 중증도 및 침습적 산소 요구량과 관련된 COVID-19 환자의 조절되지 않은 면역 반응Immunology Published on 2021-10-212022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activated T cell addition analyzed antibody isotype cellular Community convalescent patient Convalescent patients COVID-19 COVID-19 patient eosinophils Frequency healthy controls hospital discharge immune Immune cell Immunity immunological Immunological memory information Invasive mechanical ventilation maintain mechanism moderate Monocytes nasal normal proportion outcome oxygen Oxygen therapy Pathogenesis Patient patients plasmablasts Prognosis progression Requirement Research response SARS-CoV-2 pathogenesis SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG severe COVID-19 severe COVID-19 patient Severe patient subset Th1 cell the disease the WHO [DOI] 10.3389/fimmu.2021.769059 PMC 바로가기 [Article Type] Immunology
Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels불일치 항 SARS-CoV-2 순환 B 세포 주파수 및 항체 수준에 대한 숙주 면역 상태의 영향Article Published on 2021-10-142022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody synthesis Antiviral antiviral antibodies B cell B cell repertoire caution circulating clone clones Comorbidities convalescent COVID-19 determined by develop failure frequencies Frequency functional healthcare personnel hospitalized patient hospitalized patients Human monoclonal antibody immortalized immunofluorescence Impact indirect immunofluorescence individual infected cells Level low-grade inflammation Neutralizing protective immunity reflect regulate responses reveal SARS-CoV-2 SARS-CoV-2 infected cells severe COVID-19 Severe patient severe patients statistically status two group two groups [DOI] 10.3390/ijms222011095 PMC 바로가기 [Article Type] Article
SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infectionSARS-CoV-2 감염 1년 후 COVID-19 환자의 면역 및 기능 회복Clinical Trial Published on 2021-10-132022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, 치료제, [키워드] 95% CI Adaptive immunity analyzed Anti-RBD IgG anti-receptor-binding domain antibody B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants chemiluminescence chemiluminescence immunoassay Chest CT China consequence COVID-19 COVID-19 patient COVID-19-related symptoms detectable Diagnosis discharge estimate functional General population highlight immune immune protection Immunity implication Infection Infectious diseases life long-lasting neutralization non-severe patient Outcomes research participant Patient Predictive preventive measure preventive measures prospective cohort Pulmonary function Quality of life RBD Re-infection recovered COVID-19 patient reduced remained reported risk SARS-CoV-2 immunity SARS-COV-2 infection Seroprevalence Severe patient severe patients significantly Survivors symptomatic Total variant WT SARS-CoV-2 [DOI] 10.1038/s41392-021-00777-z PMC 바로가기 [Article Type] Clinical Trial
Early predictors and screening tool developing for severe patients with COVID-19Research Article Published on 2021-10-072022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 95% CI age Area China Chinese Chronic kidney disease collected confirmed case Control Coronavirus disease 2019 COVID-19 COVID-19 patient Curve cut-off value death develop diagnosed with COVID-19 disease epidemiological feature Fever global pandemic Health Service hospitals less Logistic regression Lymphocyte count male Mortality predictor prevention Ratio Result Retrospective study risk Risk factors ROC ROC Curve Screening selected sensitivity Seven Severe case Severe patient specificity System tested with COVID-19 [DOI] 10.1186/s12879-021-06662-y PMC 바로가기 [Article Type] Research Article
Meta-analysis of single-cell RNA-seq data reveals phenotypic switching of immune cells in severe COVID-19 patientsResearch article Published on 2021-10-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Adaptive immune response Analysis B cell can be used CD14+ CD16+ monocyte CD4+ CD8+ T cell cell type cellular coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease disease severity dysregulated effective Immune cell Immune cell landscape indicate Infection innate immune response lung lung tissue M2 macrophage Macrophage management Meta-analysis moderate pandemic patients performed Peripheral blood phenotypic Phenotypic switching prognostic biomarker reached reveal RNA-Seq SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe disease Severe patient severity Single-cell RNA sequencing single-cell RNA-seq switching therapeutic tissue Transcriptome [DOI] 10.1016/j.compbiomed.2021.104792 [Article Type] Research article