Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida플로리다의 암 환자에서 SARS-CoV-2 mRNA-1273 백신 접종에 대한 항체 반응 평가Article Published on 2022-05-012022-09-12 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI age anti-CD20 anti-CD20 treatment antibody Antibody Response applied blood test calculated Cancer cancer diagnosis cancer type cohort study diagnose dose doses English enzyme-linked immunosorbent Factor geometric mean titer hematologic Hispanic IgG IgG level Immunosuppressive treatment individual lowest lymphocyte lymphoid monoclonal antibody treatment morbidity and mortality mRNA-1273 Older outcome participant Patient patients treated Patients with cancer receipt receiving response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Seroconversion Seropositivity significantly lower small molecule solid tumor Spanish T Test treated Treatment vaccination vaccine dose vaccine response white [DOI] 10.1001/jamaoncol.2022.0001 PMC 바로가기 [Article Type] Article
Advances in the Development of SARS-CoV-2 Mpro InhibitorsSARS-CoV-2 Mpro 억제제 개발의 발전Review Published on 2022-04-142022-09-11 Journal: Molecules [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] acting advance antiviral drugs carried Chemical structure Compound COVID-19 demonstrated development displaying drug effort high affinity inhibitor inhibitors Initially main protease MERS MERS-CoV MPro outbreak peptide peptides protease Proteases reactive reported SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Scientific community sequence small molecule tested these compound these compounds virus [DOI] 10.3390/molecules27082523 PMC 바로가기 [Article Type] Review
Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19Article Published on 2022-04-072022-10-04 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 3CL antiviral potency binding binding pocket cellular characterized complex Compound coronavirus Coronaviruses COVID-19 COVID-19 pandemic Critical development drug drug target eliminating human cells in vivo inhibit SARS-CoV-2 inhibiting Lead optimization maturation Pandemics pharmacokinetic Potential treatment protease Protease inhibitor Proteases Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected small molecule small molecule inhibitor Small molecules specificity stability Structure the SARS-CoV-2 therapy these compounds Treatment [DOI] 10.1038/s41467-022-29413-2 PMC 바로가기 [Article Type] Article
Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors라벨이 없는 이중 SAMDI-MS 화면은 새로운 SARS-CoV-2 3CLpro 억제제를 보여줍니다Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro activities acute respiratory syndrome Analysis Anti-viral Antiviral compound Antiviral compounds assays biochemical assay cathepsin cathepsin L cellular cytotoxicity chymotrypsin completion coronavirus COVID-19 cysteine cysteine protease described dose response evaluated feature gold High-throughput screening Human rhinovirus inhibitor mass mass spectrometry matrix monolayer optimization protease Protease inhibitor Proteases required reveal rhinovirus rhinoviruses SARS-CoV-2 selective selectivity Severe acute respiratory syndrome small molecule specific inhibitor structure activity relationship therapeutic target [DOI] 10.1016/j.antiviral.2022.105279 PMC 바로가기 [Article Type] Article
In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs임상적으로 이용 가능한 약물의 표적으로서 SARS-CoV-2 단백질의 in silico 분석Article Published on 2022-03-292022-09-11 Journal: Scientific Reports [Category] Coronavirus, SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amprenavir Analysis avanafil binding binding site calcipotriol caused cells clinically Compound coronavirus develop disease docked docking domain Domperidone drug FDA-approved drug FDA-approved drugs filtered framework had no Huh-7 human liver identify in vitro involved levomefolic acid Mac1 moderate molecular dynamics Molecular dynamics simulation molecular dynamics simulations Nintedanib non-structural protein NSP Nsp15 nucleocapsid protein pandemic predicted provide reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs Spike protein target target proteins targets the spike protein Treatment Viral RNA Virtual screening [DOI] 10.1038/s41598-022-08320-y PMC 바로가기 [Article Type] Article
Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19항바이러스 대사 산물 3'-deoxy-3',4'-didehydro-cytidine은 혈청에서 검출 가능하며 COVID-19를 포함한 급성 바이러스 감염 식별Article Published on 2022-03-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute viral infection Admission an area Antiviral AUC Bacterial Bacterial infection Bacterial infections Biomarker characteristic CMPK2 Cohort correlated COVID-19 Critical cytidine ddhC detectable Diagnosis diagnostic diagnostics emergency department enzyme Enzymes examined FIVE Gene Expression healthy controls High-resolution highlight identify implicated in viral in vivo independent inflammatory conditions interferon Liquid chromatography management marker mass spectrometry metabolite metabolome metabolomics NIHR pandemic Patient precursor Profiling receiver operating characteristic receiver operating characteristic curve responsible sera serum significantly small molecule Support transcripts validation cohort viperin Viral viral infection viral infections [DOI] 10.1016/j.medj.2022.01.009 PMC 바로가기 [Article Type] Article
Inhibition of ACE2-Spike Interaction by an ACE2 Binder Suppresses SARS-CoV-2 EntryACE2 바인더에 의한 ACE2-스파이크 상호작용의 억제는 SARS-CoV-2 진입을 억제합니다Article Published on 2022-03-072022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 ACE2 Inhibition Allostery binder Compound COVID-19 COVID-19 pandemic cultured cell cultured cells effective enzymatic activity host cell host cells impairing inhibit SARS-CoV-2 inhibited inhibiting inhibition Interaction middle modulating physiological functions PPI PPI Inhibition Prevent SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 Spike RBD SARS-CoV-2 variant SARS-CoV-2 variants small molecule suppressed therapeutic strategy Vaccine variant viral infection virus entry [DOI] 10.1002/anie.202115695 PMC 바로가기 [Article Type] Article
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL proteaseSARS-CoV-2 3CL 프로테아제의 새로운 공유 억제제의 실리코 스크리닝 기반 발견Article Published on 2022-03-052022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] 3CL 3CL pro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral target approach carried catalytic complex Compound coronavirus coronavirus disease Coronavirus disease 2019 covalent binding covalent inhibitor COVID-19 crystal crystal structure database effective enzymatic activity evaluated example feasible identify inhibitor Interaction ligand binding pocket predicted protease provided residue SARS-CoV-2 SARS-CoV-2 3C-Like protease seeking severe acute respiratory syndrome Coronavirus small molecule the SARS-CoV-2 Treatment Virtual screening X-ray [DOI] 10.1016/j.ejmech.2022.114130 PMC 바로가기 [Article Type] Article
Oral antivirals for the prevention and treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 예방 및 치료를 위한 경구용 항바이러스제Article Published on 2022-03-012022-09-11 Journal: AIDS reviews [Category] SARS, 변종, 치료제, [키워드] advent Antiviral antiviral therapy antivirals benefit classical combination therapies combination therapy complications COVID-19 COVID-19 disease COVID-19 pandemic Disease progression dissemination Each early treatment Emergency use authorization escape mutant Formulation Infection landscape life-threatening Long-ActingAntivirals manifestation medications Medicine molnupiravir monoclonal antibodies monoclonal antibody Mutagenesis Nirmatrelvir offer oral Oral Remdesivir parenteral administration polymerase Prevent Prophylaxis protease protease inhibitors PROTECT provided reduce regulatory agencies regulatory agency Remdesivir required SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease small molecule treat Treatment Vaccine variant viral illnesses waning immunity [DOI] 10.24875/AIDSRev.22000001 PMC 바로가기 [Article Type] Article
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors새로운 당화 기반 치료제 - 글리옥살라제 1 유도제 및 글리옥살라제 1 억제제Review Published on 2022-02-232022-09-10 Journal: International Journal of Molecular Sciences [Category] 비임상, [키워드] Activation active against aging alleviate apoptotic appear Breast cancer breath cancer chemotherapy Cell cell line Chemotherapy clinical impact clinical trial clinically Combination Complication contribute correction diabetes dicarbonyl stress disease DNA double-blind dysfunction evaluated expression Glioblastoma glioblastoma multiforme Glo1 Glycation glyoxalase hesperetin IMPROVE in vitro in vivo inactivation Increased induce inducer inhibitor insulin insulin resistance low-grade inflammation malaria metabolism methylglyoxal mice multidrug-resistant National Cancer Institute obese outcome outcomes pathogenic Placebo placebo-controlled Protein Proteins prototype Randomized resveratrol SARS-CoV-2 small molecule spliceosome Stress subjects survival therapeutic therapy Treatment Tumor tumor cell line tumors type 2 diabete type 2 diabetes unfolded protein response Vascular [DOI] 10.3390/ijms23052453 PMC 바로가기 [Article Type] Review