Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World PopulationArticle Published on 2021-12-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Algorithms allele Antigen caused class conserved contribute Coverage COVID-19 pandemic criteria CTL cytotoxic T-cells docking epitope epitope mapping FIVE helper T-cells HLA HLA-A*24:07 HTL human leukocyte antigen IFNγ immunoinformatics in vitro study Indonesia Infection leukocyte linkers Microbiome multi-epitope peptide-based vaccine ORF1ab peptide peptides physicochemical characteristics Population predominant Protective reducing reflected Region responses SARS-CoV-2 shown stimulate Symptom T-cell T-cell epitopes T-cell Response the vaccine TLR4 toll-like receptor 4 vaccine construct Vaccine design variant β-defensin [DOI] 10.3390/vaccines9121459 PMC 바로가기 [Article Type] Article
Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus InfectionArticle Published on 2021-11-282022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACSL1 administration ameliorated Apoptosis approach C57BL/6 caused Cell coronavirus Coronavirus infection expression Ferroptosis Genes Hepatitis Host hyper-inflammation in vivo indicate induce inducer infected cells Infection Inflammatory cytokine inhibited inhibitor intranasal involved Lung inflammation lytic cell death Macrophage macrophages MHV-A59 mice mouse hepatitis virus (MHV) murine necroptosis pathogenicity performed Potential treatment PROTECT pyroptosis released RNA-Seq shown suppressed Syncytia syncytia formation targeting therapy tissue injury TLR4 upregulate upregulation viral propagation virus strain [DOI] 10.3390/v13122383 PMC 바로가기 [Article Type] Article
Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting InflammationReview Published on 2021-11-262023-06-14 Journal: Cells [Category] MERS, [키워드] α7-nicotinic acetylcholine receptor Cancer COVID-19 DAMP HMGB1 Inflammation Nociceptor RAGE SIRT1 TLR4 [DOI] 10.3390/cells10123323 PMC 바로가기 [Article Type] Review
Immunological and Preventive Effects of Hochuekkito and Kakkonto Against Coronavirus Disease in Healthcare Workers: A Retrospective Observational StudyPharmacology Published on 2021-11-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] abdominal discomfort activating Activation acute respiratory syndrome administration Against analyzed animal model antibodies biological property Cell changes in circulating Clinical data Clinical studies clinics compounds coronavirus coronavirus disease COVID-19 diarrhea Effect effective electronic medical records ENhance expected experiments expressing expression fatigue FIVE HCW HCWs healthcare worker Healthcare workers higher risk hochuekkito hospital iCoS immune cells immunological immunomodulation immunomodulatory effects increase in indicate induce Infection Infectious disease investigated kakkonto Kampo Kampo formulas Kampo medicine lymphocyte modulate myalgia NKG2A outbreak OX40 Patient patients populations presence of antibody Prevent PROTECT receptor Regulation Safe SARS-CoV-2 Side effect significant increase significantly increased specimen Stool study population surface markers T cell T cells tested TLR4 Toxicity worsening [DOI] 10.3389/fphar.2021.766402 PMC 바로가기 [Article Type] Pharmacology
Candidate genes of SARS-CoV-2 gender susceptibilityArticle Published on 2021-11-092022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome ADAM10 Affect Analysis applied association bioinformatics BST2 candidate cascade CCR5 complement Computational biology and bioinformatics coronavirus COVID-19 disease Effect effective ENPEP evaluate expressed GATA1 Gender Genetic genetics gonadal host cell human protein immunology Infection initiated Interaction IRF1 IRF2 likelihood men molecular outcome ovarian pandemic Pathways performed reaction receptor signaling response SARS-CoV-2 SARS-CoV-2 treatment SERPING1 severity of symptoms Sex difference susceptibility target the SARS-CoV-2 tissue TLR4 TLR7 TMPRSS2 Topic understanding Variation women [DOI] 10.1038/s41598-021-01131-7 PMC 바로가기 [Article Type] Article
Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients증가된 LPS 수준은 전신 염증과 공존하며 심각한 COVID-19 환자에서 단핵구 활성화를 초래합니다Article Published on 2021-11-012022-09-12 Journal: International immunopharmacology [Category] MERS, SARS, 진단, [키워드] Activation alteration analyzed association Bacterial blood sample CCL2/MCP-1 CCR2 CCR5 CCR7 CD14 CD16 CD69 Cell cell line Chemokine receptor chemokines collected Concentration Control controls COVID-19 COVID-19 patient COVID-19 patients Cytokines dead death Diseases evaluate expression flow cytometry Hospital admission hospital discharge Hospitalization hyperinflammation IFN-γ IL-6 Increased incubated Inflammation LPS marker microbial microbial translocation monocyte Monocyte activation mucosal barrier nine Non-COVID-19 non-survivor outcomes Pathogenesis Patient phenotype plasma Pneumonia positive patient SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2-infected patients severe COVID-19 severe COVID-19 patient survivor systemic cytokine systemic inflammation TGF-β1 THP-1 TLR4 TNF-α translocation worsening [DOI] 10.1016/j.intimp.2021.108125 PMC 바로가기 [Article Type] Article
miRNA-223 as a regulator of inflammation and NLRP3 inflammasome, the main fragments in the puzzle of immunopathogenesis of different inflammatory diseases and COVID-19염증 조절제로서의 miRNA-223 및 다양한 염증성 질환 및 COVID-19의 면역 병인 발생 퍼즐의 주요 단편인 NLRP3 인플라마좀Review Published on 2021-11-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress syndrome antioxidant antiviral role caspase caspase-1 CCL3 Control COVID-19 CXCL2 distress Factors feature FOXO1 genomic sequence HDAC2 IFN-I IKKα IL-18 IL-1β IL-6 Immunopathogenesis implicated infection with SARS-CoV-2 Inflammation inflammatory disease inflammatory process involved ITGB3 lung Lung injury mechanism miR-223 miR-223. miRNA monocyte-macrophage neutrophil neutrophil recruitment NF-κB NLRP3 NLRP3 inflammasome PARP PI3K pro-inflammatory responses Regulatory remained respiratory distress Respiratory distress syndrome SARS-CoV-2 STMN1 TLR4 Traf6 variety with COVID-19 [DOI] 10.1007/s00210-021-02163-6 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 MicrogliaArticle Published on 2021-10-282022-10-30 Journal: Molecular neurobiology [Category] COVID-19, [키워드] accumulating Activation addition blocked caspase-1 caused CNS contribute coronavirus culture supernatant DNA binding Effect Evidence exposure IL-1β IL-6 immunofluorescence microscopy increase in Increased investigated involved MAPK mechanism microglia Neuroinflammation Neurological symptom NF-κB NF-κB NLRP3 inflammasome pathology pharmacological produced Protein protein expression protein level provided reduction in respiratory complication Result RNA SARS-CoV-2 SARS-CoV-2 spike protein S1 SARS‐CoV‐2 spike Spike protein stimulated supplementary material the disease the spike protein TLR4 TNF-α transcriptional activity was reduced [DOI] 10.1007/s12035-021-02593-6 PMC 바로가기 [Article Type] Article
Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary MacrophagesArticle Published on 2021-10-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Asparagus officinalis L. activating acute respiratory syndrome analyzed Asparagus attenuate attenuation Cell Cell signaling coronavirus coronavirus disease COVID-19 Degradation EAS Effect elicit enzyme-linked immunosorbent examined excessive inflammation Extract functional greater Host hydrogen peroxide IL-1β IL-6 induce Infection Inflammation inhibitor inhibitors Macrophage macrophages MAPK Mortality mRNA level N-terminal not affect nuclear nuclear translocation p65 patients with COVID-19 Phosphorylation polymerase chain pro-inflammatory cytokine pro-inflammatory response pro-inflammatory signaling Production Protein Proteins reducing reported reverse transcription S1 subunit SARS-CoV-2 secretion severity Signaling significantly Simultaneous treatment Skin fibroblasts spike Spike protein STEM subunit suppressed Suppressing the SARS-CoV-2 TLR4 toll-like receptor 4 Transcription ultraviolet unique viability were assessed [DOI] 10.3390/molecules26206189 PMC 바로가기 [Article Type] Article
Inhaled [D-Ala 2 ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung InjuryResearch Article Published on 2021-09-272022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, [키워드] abrogate acute lung injury acute respiratory distress airway epithelial cell ARDS bind Box caused cellular chemokines COVID-19 Critical Cytokine storm Cytokines cytoplasm disease severity Effect endothelial cells enzyme expression Extracellular group HMGB1 HMGB1 release HMGB1 secretion identify immune cells Inflammatory Inflammatory mediators Inhaled inhibit life-threatening lung Lung diseases lysine mechanism of action mice Mobility Model modulation mouse nuclear nucleus occur peptide Pneumonia posttranslational modifications Proinflammatory cytokine Protein pulmonary inflammation RAGE receptors redox state Release released residue respiratory infection significantly SIRT1 syndrome the SARS-CoV-2 virus therapeutic TLR4 toll-like receptor 4 translocation treating COVID-19 Treatment [DOI] 10.1155/2021/4414544 PMC 바로가기 [Article Type] Research Article