Topology – Page 5 – Communicable Diseases Research

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

SARS-CoV-2의 단거리 및 장거리 RNA-RNA 상호작용체

Article

Published on 2020-12-172022-09-10
Journal: Molecular Cell [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Antiviral strategies arch base bases Bearing Cell cells Comprehensive COMRADES conserved Coronaviridae coronavirus COVID-19 COVID-19 pandemic dependent on develop discontinuous transcription distal effort elements engage etiologic agent family FSE-arch full-length SARS-CoV-2 genome Host host-virus include Interaction interactome mapped mechanism MERS-CoV Multiple network nucleotides Pathways regulate Replication resulting ribosomal frameshifting RNA RNA structure RNA virus RNA-RNA interaction RNA-RNA interactions RNAs SARS-CoV-2 SARS-CoV-2 genome single-stranded RNA genome single-stranded RNA genomes Structure subgenomic mRNAs the SARS-CoV-2 genome topologies Topology translation Viral viral genome viral transcription virus virus RNA viruses
[DOI] 10.1016/j.molcel.2020.11.004 PMC 바로가기 [Article Type] Article

Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Article

Published on 2020-10-272022-10-04
Journal: Nature Communications [Category] 변종, 신약개발,

Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology

Research

Published on 2020-10-162022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research

“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study

Pharmacology

Published on 2020-10-082022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome Analyzer Antiviral Apoptosis Bioavailability biological processes caused China Chinese Clinical efficacy Clinical treatment combination therapy Combined combined treatment component components Compound conducted control group coronavirus coronavirus disease COVID-19 COVID-19 patient criteria Cytoscape database determine Fei Yan NO1 Gene ontology identify immune response indicated Inflammation KEGG KEGG pathway Kyoto network network pharmacology offered oral outbreak parameter pathway enrichment Pathways Patient Potential PPI proportion protein-protein interaction public health regulated Regulation Renmin Hospital representing Retrospective study RT-PCR SARS-CoV-2 SARS-CoV-2 nucleic acid selected significantly higher Symptom target targets TCM TCMSP TCMSP database therapeutic Topology treat Treatment treatment for COVID-19 were used
[DOI] 10.3389/fphar.2020.581277 PMC 바로가기 [Article Type] Pharmacology

Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning

Article

Published on 2020-09-262022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Therapeutic mechanism of Toujie Quwen granules in COVID-19 based on network pharmacology

Research

Published on 2020-09-242022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] ACE ACE2 Analysis approach BCL2L1 BDKRB2 benefit biological function cascades CASP3 Chinese clusterProfiler package co-expressed Coagulation Compound coronavirus disease COVID-19 cytoHubba Cytoscape drug-likeness effective effort EGFR enrichment enrichment analysis Epidemic ESR1 FPR2 function Granule help HIF-1 Immunity Inflammatory Inflammatory response ingredient kaempferol knowledge Luteolin MAPK signaling mechanism mediated immunity Mild MPO network pharmacology neutrophil Ontology oral bioavailability pathway patients performed pharmacological mechanism PI3K-Akt signaling potential mechanism potential therapeutic target potential therapeutic targets predict progression protein-protein interaction quercetin R software Regulation Result screenings signaling pathway signaling pathways STAT3 Stress suggested Symptoms target TCMSP the disease therapeutic Topology Toujie Quwen granule Treatment treatment for COVID-19 Venn diagram was performed was used were used
[DOI] 10.1186/s13040-020-00225-8 PMC 바로가기 [Article Type] Research

SARS-CoV-2 envelope protein topology in eukaryotic membranes

1001

Published on 2020-09-092022-10-29
Journal: Open Biology [Category] COVID-19, SARS,

A database resource and online analysis tools for coronaviruses on a historical and global scale

Original Article

Published on 2020-08-052022-11-01
Journal: Database: The Journal of Biological Databases and [Category] COVID-19, MERS, SARS,

Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine development

Research

Published on 2020-07-102022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, SARS,

[키워드] ACE-2 receptor protein ACE2 Analysis antigenicity binding conserved COVID 19 database develop domain Effect Effects energetics epitope Epitope designing and screening extreme genetic material glycoprotein glycosylation Health Host IC50 inhibitor manifested MERS-CoV MHC II motif mutations Ontology outbreak PyMol reactivity regimen Region Result SARS CoV SARS CoV-2 SARS CoV-2 (COVID 19) SARS-CoV SARS-CoV-2 screened selected server Severe global outbreak-Dec 2019 spike glycoprotein Spike protein stability the SARS-CoV-2 therapeutic Topology vaccination Vaccination strategy Vaccine Vaccine development viral spike virulence ZDOCK
[DOI] 10.1186/s12967-020-02435-4 PMC 바로가기 [Article Type] Research

Prediction of COVID-19 spreading profiles in South Korea, Italy and Iran by data-driven coding

Research Article

Published on 2020-07-062022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] application China coding collected Complete Contact COVID-19 data-driven Epidemic expected Infection initial Iran Italy less mechanism occur outbreak parameter prediction profile profiles progression representing SEIR selected South Korea the epidemic Topology Transmission variety
[DOI] 10.1371/journal.pone.0234763 PMC 바로가기 [Article Type] Research Article