Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine inductionResearch Article Published on 2021-11-182022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies Antiviral antiviral activity approach binding binding affinity cell entry Contact crystal structure demonstrated Effect experiment expressing glycoprotein high affinity host cell human cell Inflammation inhibiting inhibitor Interaction linear majority membrane nanobody neutralisation assay peptide peptides pro-inflammatory cytokine RBM Receptor binding domain receptor binding motif residue responsible S RBD SARS-CoV-2 SARS-CoV-2 viral selected sequence soluble ACE2 Spike protein suggested suppress the S1 subunit the SARS-CoV-2 the spike protein to define trimer viral cell viral spike viral spike protein virulence [DOI] 10.1371/journal.pone.0260283 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strainsSARS-CoV-2 B.1.1.7(알파) 및 B.1.351(베타) 변이체는 초기 균주와 구별되는 K18-hACE2 형질전환 마우스에서 병원성 패턴을 유도합니다Article Published on 2021-11-122022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta Adaptive immunity Alpha Antibody neutralization Antimicrobial responses B.1.1.7 B.1.351 caused combating COVID-19 cytokine D-dimer death hACE2 help hypoxia Immunity immunization induce Infection intramuscular K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice lesion less medical intervention mice Mutant SARS-CoV-2 neutralization titer organ pathogenic pathology Receptor binding domain reduced Reinfection resulting SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Signaling strain Strains Transgenic mouse Transmissibility variant variants variants of concern Viral viral infection viral spike virulence VoC VOCs [DOI] 10.1038/s41467-021-26803-w PMC 바로가기 [Article Type] Article
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvantArticle Published on 2021-11-082022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] addition adjuvants Antigen antigen-specific antibody B.1.1.7 B.1.351 variant binding Body weight loss Cellular immune response convalescent plasma COVID-19 pandemic evaluated humoral Infectious diseases mice Neutralizing Neutralizing activity platform protein subunit vaccine Protein vaccines reducing robust SARS-CoV-2 SARS-CoV-2 vaccine single vaccination SLA sulfated the spike protein Vaccine Vaccines viral infection Viral load viral spike [DOI] 10.1038/s41598-021-01363-7 PMC 바로가기 [Article Type] Article
Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2Article Published on 2021-10-222022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] anti-S anti-S antibody Anti-SARS-CoV-2 S antibodies antibody Blood blood sample carried Clinical studies Cohort Combination composed COVID-19 infection COVID-19 pandemic determine dose Elecsy first vaccination Frequency had no Immune status immunoassay Immunoglobulin individuals information investigated Level limit neutralizing antibodies detection neutralizing antibody Patient peaked persistence Pfizer plasma Population populations produced progression PROTECT Protein Quantitative quantitative dried blood spots random Roche SARS-CoV-2 second dose serum/plasma spot stimulated subject subjects vaccination vaccination against SARS-CoV-2 Vaccine venous viral spike Volunteer [DOI] 10.3390/life11111125 PMC 바로가기 [Article Type] Article
Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection ComplicationsCOVID-19 병인 및 감염 후 합병증에서 Annexin A2의 가능한 역할에 대한 분자적 통찰력Review Published on 2021-10-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Annexin Annexin A2 Antiviral AnxA2 clinically Complication complications Continuous COVID-19 cytokine Cytokine storm develop docking effective drug effective drugs effort Evidence glycoprotein in silico individual Infection insight insulin insulin resistance interactions internalization knowledge lack management molecular molecular mechanism molecular mechanisms mutated outbreak Pathogenesis performed Post-infection Prophylactic Protein provide Replication respiratory RNA-dependent RNA polymerase role SARS-CoV-2 SARS-CoV-2 pathogenesis Severe acute respiratory syndrome spike glycoprotein the SARS-CoV-2 thrombosis treat Vaccine Viral viral infection viral pathogenesis viral spike [DOI] 10.3390/ijms222011028 PMC 바로가기 [Article Type] Review
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodiesCOVID-19 기증자 유래 중화 항체의 하위 집합에 의해 나타나는 사베코바이러스 전반에 걸친 광범위한 교차 반응성Article Published on 2021-09-282022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-RBD antibodies Anti-RBD antibody anti-SARS-CoV-2 antibody avidity binding site breadth CDRH3 changes class coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity crosslinking cryo cryo-EM Donor epitope Epitopes exhibited facilitate H-bond interaction neutralization Neutralizing Neutralizing antibodies neutralizing antibody occlude potent RBD RBD-binding antibody RBDs Receptor-binding domain recognize reducing respiratory reveal sarbecovirus SARS-CoV-2 SARS-CoV-2 variants sensitivity spike spike trimer Spike trimer: structural biology structural biology Structure subset trimer Vaccine design variants Viral viral spike Virology virology: X-ray crystallography. X-ray crystallography Zoonotic coronavirus zoonotic coronaviruses zoonotic sarbecovirus [DOI] 10.1016/j.celrep.2021.109760 PMC 바로가기 [Article Type] Article
The Possible Role of Microbial Proteases in Facilitating SARS-CoV-2 Brain InvasionOpinion Published on 2021-09-272022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 activate Angiotensin-converting enzyme Brain Cell cells Co-infection Cryptococcus Endothelial cell expression facilitate Facilitating fungal glycoprotein information instance Intervention Invasion Measures mechanism membrane fusion microbe microbial neurotropism organ Pathogens protease role S2 domain SARS-CoV-2 secretion shown simple understanding viral spike virus [DOI] 10.3390/biology10100966 PMC 바로가기 [Article Type] Opinion
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants교차 중화 항체는 SARS-CoV-2 잠복 부위에 결합하고 순환 변이체에 저항합니다Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affinity antibodies antibody Antibody therapeutics causative agent circulating SARS-CoV-2 variants circulating variant conserved COVID-19 COVID-19 pandemic cross-neutralizing antibody crystal structure crystal structures disrupt domain epitope Epitopes global effort global efforts isolates Mutation N-terminal domain neutralize Neutralizing antibodies public health RBD Receptor-binding domain recognize sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants several variant several variants the RBD the receptor-binding domain Vaccines variants of SARS-CoV-2 Viral viral infection viral spike virus variants X-ray crystallography [DOI] 10.1038/s41467-021-25997-3 PMC 바로가기 [Article Type] Article
The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 VariantsAntiviral Agents Published on 2021-09-202022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 activity addition analogue Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective small molecule stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell viral entry viral spike [DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents
The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants천연 stilbenoid (-)-Hopeaphenol은 SARS-COV-2 USA-WA1/2020, B.1.1.7 및 B.1.351 변이체의 세포 진입을 억제합니다.Antiviral Agents Published on 2021-09-202022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 변종, [키워드] ACE2 ACE2 binding activities activity addition Alpha analogue angiotensin Angiotensin-converting enzyme Antiviral Antiviral agents B.1.1.7 B.1.351 Beta binding Compound Concentration coronavirus COVID-19 Cytopathic effect cytotoxicity effective effective inhibitor example expressing Host identify in vitro Infectious virus inhibited inhibitor inhibitory concentration interfere natural natural products pandemic pseudovirus pseudovirus assay pseudovirus assays RBD receptor Receptor binding domain reduction Remdesivir Replication reporter resveratrol SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant screened selective selectivity index small molecule Small molecules stilbenoid stilbenoids USA-WA1/2020 Vaccine variant variants of concern Vero-E6 cell Vero-E6 cells Viral viral entry viral spike VSVΔG [DOI] 10.1128/AAC.00772-21 PMC 바로가기 [Article Type] Antiviral Agents