Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2Letter Published on 2020-05-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] ACE2 angiotensin-converting enzyme 2 antibody Convalescent plasma therapy COVID-19 cross-neutralization demonstrated detectable Efficacy entry receptor Infection initial neutralizing antibody protective immunity SARS SARS patient SARS-CoV SARS-CoV-2 SARS-related coronavirus sera serologic tests significant level Vaccine virus [DOI] 10.1080/22221751.2020.1761267 PMC 바로가기 [Article Type] Letter
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article
Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroidsArticle Published on 2020-05-082022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 치료법, [키워드] accelerate anti-IL6 antibody benefit cell entry Characteristics clinical benefit Controlled clinical trial correlated Corticosteroid Corticosteroids COVID-19 COVID-19-related death cytokine essential element fatal disease humans Hypothesis IL6 immune system Immunoglobulin immunoglobulins immunosuppressive IMPROVE Inflammation interleukin 6 monoclonal antibody Novel coronavirus outcomes Patient patients with COVID-19 pro-inflammatory cytokine Prognosis prognosis of patient rationale reduce SARS-CoV2 severe COVID-19 severity shown target targeted therapy therapeutic option therapy Treatment use of corticosteroid Viral load with COVID-19 [DOI] 10.1016/j.intimp.2020.106560 PMC 바로가기 [Article Type] Article
Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirusResearch Article Published on 2020-05-082022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] absence antibodies antibody Antiviral antiviral agent B cell B-cell candidate cause characterization contributing to domain East expressing FIVE high affinity high mortality rate human DPP4 human infection Human monoclonal antibody humans immunization Immunoglobulin infect low dose MERS-CoV Middle East Neutralizing PBMC cell prefusion probe Prophylactic RBD RBD-specific antibody respiratory syndrome coronavirus severe respiratory infection Spike protein suggested therapeutic transgenic mice Treatment Vaccine [DOI] 10.1371/journal.pone.0232757 PMC 바로가기 [Article Type] Research Article
Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched BetacoronavirusResearch Article Published on 2020-05-062022-10-30 Journal: mSphere [Category] Coronavirus, MERS, [키워드] age antibody assessment clinical disease collected concerning confidence interval coronavirus cross-reactivity cutoff value dependent on detect diagnostic disease ELISA Encephalomyelitis Endemic enzyme-linked immunosorbent epidemic diarrhea evaluate evaluated Evidence family Coronaviridae female gastroenteritis groups Health Immune status Immunity infect Infection infections information inoculated knowledge lactogenic mammals mechanism member MONITOR monitoring Neonatal populations Porcine deltacoronavirus porcine encephalomyelitis virus porcine hemagglutinating encephalomyelitis virus prevalent provide provided question raised Respiratory Coronavirus seropositive Seroprevalence serum IgG serum sample the mean the S1 protein thought Vaccine variety virus vomiting and wasting disease [DOI] 10.1128/mSphere.00199-20 PMC 바로가기 [Article Type] Research Article
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization AssaysProtocol Published on 2020-05-062022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 293T cell 293T-ACE2 ACE2 Affect ALAYT antibody Antibody binding assays ATCC BEI Resource Cell complement coronavirus COVID-19 cytoplasmic tail demonstrated described Express human sera Immunity infect lentiviral Lentiviral particle lentiviral pseudotype luciferase neutralization Neutralization assay Neutralizing activity Neutralizing antibodies NIH Particle Particles plasma Protein protocol pseudotype pseudotyped lentiviral particle pseudotyping reagent receptor Repository retroviral SARS-CoV-2 sera spike the SARS-CoV-2 vesicular stomatitis virus viral infection viral particle virus VSV [DOI] 10.3390/v12050513 PMC 바로가기 [Article Type] Protocol
Detection of IgM and IgG antibodies in patients with coronavirus disease 2019Original Article Published on 2020-05-062022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] acute respiratory syndrome antibody chemiluminescence immunoassay coronavirus coronavirus disease Course COVID‐19 COVID‐19 patients COVID‐19 Critical case critical cases Critical disease Deceased detectable detection determine Disease activity group groups IgG IgG antibody IgG level IgM IgM and IgG IgM antibody level Illness severity immune response Immunoglobulin G immunoglobulin M Mild mild cases not significantly different objective Patient patients peaked positive rate reached recovered patients reduced remained responses against Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe cases severity and prognosis significantly the disease undetectable was increased were assessed [DOI] 10.1002/cti2.1136 PMC 바로가기 [Article Type] Original Article
Development of an inactivated vaccine candidate for SARS-CoV-2SARS-CoV-2 불활화백신 후보물질 개발Report Published on 2020-05-062022-09-14 Journal: Science (New York, N.y.) [Category] MERS, SARS, 비임상, 진단, [키워드] antibody Antibody-dependent enhancement caused clinical development Complete coronavirus disease COVID-19 development different dose dose effective vaccine humans immunization inactivated Inactivated vaccine Infection macaque mice neutralized Neutralizing non-human primates pandemic PiCoVacc provided public health crisis purified SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 virus SARS-CoV-2-specific neutralizing antibody Support Treatment Vaccine vaccine candidate virus [DOI] 10.1126/science.abc1932 PMC 바로가기 [Article Type] Report
A human monoclonal antibody blocking SARS-CoV-2 infectionArticle Published on 2020-05-042022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibody caused Cell culture coronavirus coronavirus SARS-CoV-2 COVID-19 cross-neutralizing disease Epidemic epitope Human monoclonal antibody Immunotherapy neutralize Neutralizing offer Respiratory disease SARS-CoV SARS-CoV-2 SARS-COV-2 infection target Treatment Virology virus Wuhan, China [DOI] 10.1038/s41467-020-16256-y PMC 바로가기 [Article Type] Article
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencingArticle Published on 2020-05-042022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] affected Analysis antibody B cells BCR caused CD14 CD4 CD8 Cell change classical Course COVID-19 COVID-19 patient COVID-19 patients early recovery Evidence expressed frequencies Gene Expression greater hospital discharge identification IGHV3-15 IGHV3-23 IGHV3-30 IGHV3-7 IGKV3-11 IL-18 IL-1β IL-2 IL-4 IL1β Immune cell immune signature immunology indicated Inflammatory inflammatory gene inflammatory storm isotype M-CSF Mechanisms of disease monoclonal monocyte mononuclear cell naïve B cell Patient Peripheral blood Plasma cell predicted provide reported SARS-CoV-2 Sequencing Signaling significantly single-cell Single-cell RNA sequencing specificity subset T cell target gene TNFSF13 transcriptional change Treatment Vaccine Vaccine development virus [DOI] 10.1038/s41421-020-0168-9 PMC 바로가기 [Article Type] Article