Alanine – Page 6 – Communicable Diseases Research

Epidemiological and clinical presentations of hospitalized COVID-19 patients in Libya: An initial report from Africa

리비아에서 입원한 COVID-19 환자의 역학 및 임상 프리젠테이션: 아프리카의 초기 보고서

Article

Published on 2021-07-012022-09-11
Journal: Travel medicine and infectious disease [Category] SARS, 변종,

Dipeptidylpeptidase-4 levels and DPP4 gene polymorphisms in patients with COVID-19. Association with disease and with severity

COVID-19 환자에서 Dipeptidylpeptidase-4 수준 및 DPP4 유전자 다형성.질병과의 연관성 및 심각성

Article

Published on 2021-07-012022-08-31
Journal: Life sciences [Category] SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alanine alanine aminotransferase albumin Analysis angiotensin Angiotensin converting enzyme-2 angiotensin-converting enzyme-2 association carrier cause controls coronavirus correlated COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Dipeptidyl peptidase-4 Dipeptidylpeptidase-4 disease DPP4 enzyme fibrinogen functional Genotype healthy control healthy controls high risk Invasive mechanical ventilation lowest mechanical ventilation Neutrophils not need Patient patients with COVID-19 Platelet polymorphism Polymorphisms quantified receptor reported required respiratory SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity suggested TaqMan assays virus with COVID-19
[DOI] 10.1016/j.lfs.2021.119410 PMC 바로가기 [Article Type] Article

Association Between the Concentration and Rangeability of Cystatin C and Mortality of COVID-19 Patients With or Without Type 2 Diabetes Mellitus: A Retrospective Analysis

시스타 틴 C의 농도 및 범위 성 사이의 연관성과 제 2 형 당뇨병이 있거나없는 CovID-19 환자의 사망률 사이의 연관성 : 후 향적 분석

Endocrinology

Published on 2021-06-212022-08-31
Journal: Frontiers in Endocrinology [Category] MERS, SARS, 바이오마커,

[키워드] 95% CI Alanine alanine aminotransferase all-cause death Analysis analyzed aspartate Aspartate aminotransferase association blood lymphocyte C-reactive protein Care Characteristics Clinical data Concentration confounders coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cystatin C death demographic demographic characteristics diabetes Diabetes Mellitus Follow-up four group four groups group had more heart failure higher risk Hospitalization Intervention investigated laboratory result Laboratory results Lymphocytes Multivariate analysis organ damage Patient Prognosis renal function Result risk serum significantly Type type 2 diabete Type 2 diabetes mellitus
[DOI] 10.3389/fendo.2021.642452 PMC 바로가기 [Article Type] Endocrinology

SARS-CoV-2-Related Subacute Thyroiditis, Myocarditis, and Hepatitis After Full Resolution of COVID-19 Serum Markers

COVID-19 혈청 마커의 완전한 해결 후 SARS-CoV-2 관련 아급성 갑상선염, 심근염 및 간염

Case Reports

Published on 2021-06-172022-09-11
Journal: The American journal of case reports [Category] MERS, SARS, 바이오마커,

[키워드] Admission Alanine alanine aminotransferase alkaline phosphatase aspartate Aspartate aminotransferase Bilirubin cardiac enzyme cardiac enzymes CCU chest pain clinically Coronary Coronary Care Unit COVID-19 COVID-19 pneumonia demonstrated develop diagnose disorder Follow-up following test following tests free T4 healthy Hepatitis hospital indicated Infarction Inflammatory inflammatory disorder inflammatory disorders liver test Liver tests male multisystemic Myocardial Myocardial ischemia myocarditis Negative PCR normal on admission Outpatient Patient PCR phosphatase Pneumonia pulmonary disease radionuclide reactive relief Resolution SARS-CoV-2 SARS-COV-2 infection Serum Marker Subacute syndrome the patient Thyroid Thyroiditis thyroxine total bilirubin troponin troponin I TSH unit Viral viral infections
[DOI] 10.12659/AJCR.932321 PMC 바로가기 [Article Type] Case Reports

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Antiviral Agents

Published on 2021-06-142022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19,

[키워드] Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolism monophosphate mRNA mRNA expression nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell tissue treat Treatment turn unique Viral RNA
[DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Antiviral Agents

Published on 2021-06-142022-10-27
Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS,

[키워드] Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolism monophosphate mRNA mRNA expression nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell tissue treat Treatment turn unique Viral RNA
[DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

인간 폐 세포에서 Remdesivir 활성화에 관여하는 주요 대사 효소

Antiviral Agents

Published on 2021-06-142022-09-10
Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제,

[키워드] adenosine Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolic pathway metabolism monophosphate mRNA mRNA expression nucleoside nucleoside triphosphate nucleotide nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell target cells tissue treat Treatment triphosphate turn unique Veklury Viral Viral RNA
[DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents

Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis

COVID-19 입원의 바이오마커 및 결과: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-06-012022-08-31
Journal: BMJ evidence-based medicine [Category] MERS, SARS, 바이오마커,

[키워드] 2019-nCoV 95% CI Admission Alanine alanine aminotransferase ALT aspartate Aspartate aminotransferase association AST Biomarker Biomarkers C reactive protein clinical decision Composite Consensus coronavirus COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity creatine creatine kinase creatinine Critical Critical care CRP D-dimer Decision making Diseases elevated English evaluate evidence-based practice forest plot forest plots global health healthcare heterogeneity high-risk patient High-risk patients higher risk hospitalised patient Hospitalised patients IMPROVE In-hospital include independent Infectious disease infectious disease medicine Infectious diseases intensive care intensive care unit admission Invasive mechanical ventilation Laboratory laboratory findings Lactate lactate dehydrogenase LDH lymphocyte lymphopenia management medical subject heading Medical Subject Headings meta-analyses Meta-analysis MOOSE Mortality nCoV observational studies observational study outcome outcomes oxygen oxygen saturation pandemic PCT Platelets procalcitonin Prognosis Publication bia publication bias Random-effects models resource resources SARS-CoV-2 selected sensitivity analysis severe disease Severity of disease systematic review thrombocytopenia Web of Science were assessed
[DOI] 10.1136/bmjebm-2020-111536 PMC 바로가기 [Article Type] Meta-Analysis

Using Unsupervised Machine Learning to Identify Age- and Sex-Independent Severity Subgroups Among Patients with COVID-19: Observational Longitudinal Study

Observational Study

Published on 2021-05-272022-10-04
Journal: Journal of Medical Internet Research [Category] 임상,

[키워드] Alanine ALT applied Aspartate transaminase AST C-reactive protein characterization characterized Clinical data Cluster Clusters COVID-19 CRP data set Deceased detection Early detection Emergency highest hospital identify implication Intervention key factor Laboratory Laboratory test Laboratory tests lactate dehydrogenase LDH longitudinal lowest lymphocyte machine learning machine learning algorithm monocyte objective outcome Patient patients with COVID-19 percentage proportion protocols raise Result separate clusters Serum level severity Sex shown Spain subgroup Testing variable variables
[DOI] 10.2196/25988 PMC 바로가기 [Article Type] Observational Study

Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery

혈장 내 세포외 소포체 단백질체학, 3개월 회복 후 기저질환 없는 코로나19 환자의 특성 및 잔류 흔적 밝혀

Article

Published on 2021-05-252022-09-11
Journal: Cell Death & Disease [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술,

[키워드] addition Alanine alanine aminotransferase alkaline phosphatase ALP ALT association bleeding cellular change characteristic Characteristics Clinical characteristics Coagulation controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Ct value defined differentially expressed discharge dysfunction EVs extracellular vesicle Extracellular vesicles functions healthy subject healthy subjects Identified immune response Immunity Increasing Inflammation inflammatory reaction Intervention involved kidney mass mass spectrometry metabolic process molecular organ organ dysfunction organ function oxygen Patient phosphatase plasma Prevent Protein proteome proteomics recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Reinfection reported reveal serum electrolyte significantly lower situation Spectrometry Stress suffered underlying disease underlying diseases unique was used
[DOI] 10.1038/s41419-021-03816-3 PMC 바로가기 [Article Type] Article