Humoral response to SARS-CoV-2 adenovirus vector vaccination (ChAdOx1 nCoV-19 [AZD1222]) in heart transplant recipients aged 18 to 70 years of age18~70세 심장 이식 환자의 SARS-CoV-2 아데노바이러스 벡터 백신 접종(ChAdOx1 nCoV-19[AZD1222])에 대한 체액 반응Article Published on 2022-04-012022-09-11 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI Adenovirus adenovirus vector vaccine adenovirus vector vaccines administration adverse event age antibody Antibody Response binding domain ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chronic Chronic kidney disease CKD Concentration detectable develop domain dose enrolled fatigue female headache heart heart transplant help Humoral response immune response immunogenicity Immunosuppressed immunosuppressed patients injection site pain Kidney disease less Messenger RNA minor symptom minor symptoms mycophenolate nCoV organ Patient paucity of data PCR testing predict Prospective Study receive recent recipient recipients responses SARS-CoV-2 SARS-COV-2 infection serum analysis solid organ solid organ transplant SOT Spike protein suggested the spike protein to define vaccination Vaccine vaccine doses were recorded [DOI] 10.1016/j.healun.2022.01.005 PMC 바로가기 [Article Type] Article
MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunityArticle Published on 2022-03-252022-11-01 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] accessory protein adapter Alter binding binding domain binding mechanism biochemically canonical coronavirus Edward explain high-resolution structure highly pathogenic Host Immunity impair infected cells inhibiting innate immune innate immune response innate immune responses Innate immunity Interaction lack mechanism MERS coronavirus MERS-CoV Mutation NF-κB NLS nuclear nuclear translocation ORF4b overlap P50 Protein shown signaling pathways Structure viral infection virus Virus-host interactions X-ray crystallography [DOI] 10.1038/s41467-022-28851-2 PMC 바로가기 [Article Type] Article
Evolution of Anti-RBD IgG Avidity following SARS-CoV-2 InfectionSARS-CoV-2 감염에 따른 항-RBD IgG 결합력의 진화Article Published on 2022-03-042022-09-12 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] anti-RBD Anti-RBD IgG anti-viral antibody antibodies antibody antibody affinity antibody-secreting cell avidity B cell binding domain blood sample clone cognate antigen Cohort collected convalescent convalescent plasma COVID-19 Decline determine domain Donor elicit elicited Evolution functional Germinal center higher affinity Humoral response IgG immune response increase increase in Infection maturation memory B cells mRNA vaccination natural infection plasma produced RBD Receptor-binding domain resolution of symptoms SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection secreting short-lived vaccination [DOI] 10.3390/v14030532 PMC 바로가기 [Article Type] Article
Immunogenicity of ChAdOx1 nCoV-19 vaccine after a two-dose inactivated SARS-CoV-2 vaccination of dialysis patients and kidney transplant recipientsArticle Published on 2022-03-042022-10-04 Journal: Scientific Reports [Category] SARS, 진단, [키워드] antibody binding domain ChAdOx1 nCoV-19 vaccine control group control groups controls dialysis dose elicited enrolled greater group groups HD group Heterologous immune response immunogenicity inactivated Infectious diseases IQR kidney transplant kidney transplant recipient median Nephrology neutralization parameter participant Patient patients positive recipient remained response SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 virus significantly increased T-cell Vaccination strategy [DOI] 10.1038/s41598-022-07574-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron spike glycoprotein receptor binding domain exhibits super-binder ability with ACE2 but not convalescent monoclonal antibodySARS-CoV-2 오미크론 스파이크 당단백질 수용체 결합 도메인은 ACE2와 수퍼바인더 능력을 나타내지만 회복기 단일클론 항체는 나타내지 않음Article Published on 2022-03-012022-09-11 Journal: Computers in biology and medicine [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 antibody binding binding domain Cell Cell fusion center characterized complementarity-determining region complex complexes consequence convalescent COVID-19 Disruption exhibit expected generate glycoprotein host receptor Interaction interactions investigated less light chain mAb mAbs molecular molecular dynamics monoclonal antibody Monoclonal antibody (mAbs) Mutagenesis Mutation Neutralizing omicron Omicron variant promote provided question RBD Receptor binding domain receptor binding domain (RBD) residues S protein SARS-CoV-2 setup spike spike glycoprotein Substitution the S protein Trajectories trajectory Transmissibility variant Viral viral entry virus was used wildtype [DOI] 10.1016/j.compbiomed.2022.105226 PMC 바로가기 [Article Type] Article
SARS-CoV-2 BNT162b2 vaccine–induced humoral response and reactogenicity in individuals with prior COVID-19 diseaseSARS-CoV-2 BNT162b2 백신 유도 체액 반응 및 이전 COVID-19 질병이 있는 개인의 반응성Clinical Medicine Published on 2022-02-222022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerated Adaptive immunity antibody binding domain BNT162b2 BNT162b2 vaccine controls COVID-19 COVID-19 disease COVID-19 group dose Fever first dose greater headache Health care humoral humoral immune response Humoral response humoral responses Hypothesis IgG antibody immune immune responses individual individuals injection malaise manifested MOST mRNA vaccine Neutralizing Neutralizing activity no increase of BNT162b2 peak Pfizer protective immune response rapid increase reactogenicity Reinfection response robust SARS-CoV-2 SARS-CoV-2 BNT162b2 second dose serum serum IgG spike IgG spike receptor-binding domain supported systemic reactions Temple University tested Vaccine vaccine dose were assessed [DOI] 10.1172/jci.insight.155889 PMC 바로가기 [Article Type] Clinical Medicine
Impact on HIV-1 RNA Levels and Antibody Responses Following SARS-CoV-2 Vaccination in HIV-Infected IndividualsHIV에 감염된 개인에서 SARS-CoV-2 백신 접종 후 HIV-1 RNA 수준 및 항체 반응에 대한 영향Immunology Published on 2022-02-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effect All participant All participants Anti-RBD antibodies Anti-RBD antibody Anti-S1 antibody baseline baseline CD4 binding domain BNT162b2 CD4 T-cell collected coronavirus detectable dose elicited first dose HIV HIV-1 Immunological response Impact individual individuals Level male median median age minor mRNA vaccine mRNA vaccines mRNA1273 no statistical difference observational study offered Patient patients PLWH positive RBD reported respiratory response RNA SARS-CoV-2 second dose serology severe acute respiratory syndrome Coronavirus single-center T-cells vaccination Virological were measured with HIV [DOI] 10.3389/fimmu.2021.820126 PMC 바로가기 [Article Type] Immunology
The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine candidateSARS-CoV-2의 인간 ACE-2 수용체 결합 도메인은 비복제 바이러스 벡터 백신 후보로서 뉴캐슬병 바이러스의 바이러스 표면에서 발현Research Article Published on 2022-02-082022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor addition alum Antibody titer binding domain caused Concentration COVID-19 vaccine death demonstrated elect Express expressed Health health problem Human inactivated Infection inoculated mice neutralization Neutralizing antibodies neutralizing antibody newcastle disease virus optical density pandemic disease protective immunity pseudovirus RBD RBD protein Receptor-binding domain sandwich ELISA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus sera Spread TCID the receptor-binding domain the SARS-CoV-2 viral surface Viral vector vaccine virus were measured [DOI] 10.1371/journal.pone.0263684 PMC 바로가기 [Article Type] Research Article
Latex Microsphere-Based Bicolor Immunochromatography for Qualitative Detection of Neutralizing Antibody against SARS-CoV-2SARS-COV-2에 대한 중화 항체의 질적 검출을위한 라텍스 미세권 기반 바이 콜러 면역 산화학Communication Published on 2022-02-072022-09-01 Journal: Biosensors [Category] 진단, 치료기술, [키워드] analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody approach avoidance binding domain carried clinically conditions detection direct approach Effectiveness family functions immune system Infection Interaction Interpretation lateral flow immunoassay Latex latex microspheres LFIA limit of detection microsphere neutralizing antibody point-of-care portion positive principle Qualitative RBD Receptor binding domain reduce risk S1 subunit SARS-CoV-2 SARS-CoV-2 detection serum serum sample serum samples Severe infection Spike protein stimulate the S1 subunit the spike protein vaccination were used [DOI] 10.3390/bios12020103 PMC 바로가기 [Article Type] Communication
Latex Microsphere-Based Bicolor Immunochromatography for Qualitative Detection of Neutralizing Antibody against SARS-CoV-2Communication Published on 2022-02-072022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] analyzed angiotensin-converting enzyme 2 antibody approach avoidance binding domain carried clinically conditions detection Effectiveness functions immune system Infection Interaction Interpretation lateral flow immunoassay Latex latex microspheres LFIA limit of detection microsphere neutralizing antibody point-of-care positive Qualitative RBD Receptor binding domain reduce risk SARS-CoV-2 SARS-CoV-2 detection serum serum sample Severe infection stimulate the S1 subunit the spike protein vaccination were used [DOI] 10.3390/bios12020103 PMC 바로가기 [Article Type] Communication