Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso부르키나파소에서 하이드록시클로로퀸 또는 클로로퀸과 아지트로마이신 조합으로 치료한 COVID-19 입원 환자 및 외래 환자의 회복 시간, 악화 및 사망 평가Observational Study Published on 2022-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI adjusted aggravation assessment association Azithromycin Burkina Faso Chloroquine Chloroquine phosphate clearance death disease dose fatality Follow-up Hydroxychloroquine hydroxychloroquine plus azithromycin information Inpatient Inpatients lower risk multivariable no significant difference no significant differences observational study outcome Outpatient Patient patients with COVID-19 phosphate Poisson model provided receiving retrospective SRAS-CoV-2 statistical time Time to recovery treated Treatment viral clearance Virological with COVID-19 worsening [DOI] 10.1016/j.ijid.2022.02.034 PMC 바로가기 [Article Type] Observational Study
Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA)Research article Published on 2022-04-212022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] 28-day mortality 95% CI anti-SARS-CoV-2 antibody antibody Antibody Response assessment assigned authority benefit clearance combination therapy Coronavirus disease 2019 Coronavirus disease-19 COVACTA COVID-19 Department development died discharged double-blind Effect Efficacy and safety Europe finding funding Future Hoffmann-La Roche hospital hospital discharge hospitalised Host immune response Human impair IMPROVE Infection intensive care interleukin-6 intravenous tocilizumab investigated Mortality Nasopharyngeal swab neutralising North America occurred office other treatments Patient patient selection patients with COVID-19 Placebo placebo-controlled trial polymerase chain positive test result Potential biomarker randomised randomised controlled trial Randomly respiratory response SARS-CoV-2 SARS-CoV-2 viral load Secretary serum serum samples severe acute respiratory syndrome coronavirus-2 tested Tocilizumab Treatment viral clearance Viral load with COVID-19 [DOI] 10.1016/j.eclinm.2022.101409 [Article Type] Research article
Prolonged viral suppression with anti-HIV-1 antibody therapy Research Published on 2022-04-132022-10-05 Journal: Nature [Category] 변종, 임상, [키워드] absence administration Affect Analysis antibody ART CD4+ changes in clearance clinical study Combination Concentration decrease dose Drug administration effective Genome HIV-1 HIV-1 infection Immunotherapy individual individuals Infection neutralizing antibody performed Predictive Prolonged provirus public health reached remained required reservoir sensitivity sensitivity analysis serum Seven suppress suppressed the antibody therapy to define Viraemia Virologic suppression virus Volunteer with HIV [DOI] 10.1038/s41586-022-04597-1 [Article Type] Research
Efficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19초기 경증 내지 중등도의 COVID-19 환자 치료를 위한 소포스부비르/벨파타스비르 조합의 효능 및 안전성Multicenter Study Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Antiviral case-control study clearance clinical outcomes Combination conducted Control control group COVID-19 died Disease progression effective evaluated faster HCV Health health problem Infection Intensive median Mild Moderate COVID-19 multicenter nasal swabs once daily one patient oxygen Patient patients PCR performed prevent disease progression primary endpoint RdRP RdRp inhibitor Replication required RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection secondary endpoint Side effect sofosbuvir standard care Swab Tablet the patient treat treated Treatment Vaccines velpatasvir Ventilation viral clearance [DOI] 10.1038/s41598-022-09741-5 PMC 바로가기 [Article Type] Multicenter Study
A case of primary COVID-19 pneumonia: plausible airborne transmission of SARS-CoV-2원발성 COVID-19 폐렴 사례: SARS-CoV-2의 그럴듯한 공기 전파Case Reports Published on 2022-04-042022-09-11 Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence addition Admission aerosol Aerosols Airborne transmission airway alveolar anatomical Bioaerosols Bronchoalveolar lavage bronchoscopy Cholecystitis clearance contagious COVID-19 COVID-19 pneumonia CT scan detect Diagnosis diagnosis of COVID-19 different clinical manifestations Efficacy Evidence Ground glass opacity highlight increase in Infection limitation lower lobe lower respiratory system lung infiltrate nasal Patient Pneumonia positive qPCR right lower lobe RT-qPCR Saliva salivary SARS-CoV-2 Spread Swab Test tested Transmission transmission of SARS-CoV-2 upper airway upper respiratory upper respiratory tract Variability Viral load viral replication virus zone [DOI] 10.1186/s40001-022-00668-1 PMC 바로가기 [Article Type] Case Reports
Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis낭포성 섬유증이 있는 어린이의 SARS-CoV-2 감염 재발 후 불량한 호흡기 건강Article Published on 2022-04-012022-09-11 Journal: Indian journal of pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] allergic bronchopulmonary allergic bronchopulmonary aspergillosis Asymptomatic bronchopulmonary aspergillosis children chronic lung disease clearance clearance of SARS-CoV-2 COVID-19 COVID-19 severity Cystic cystic fibrosis described develop diabete diabetes diagnosed fibrosis High-flow nasal oxygen intensive care lung Lung disease mild infection morbidity Noninvasive ventilation oxygen Pneumonia Poor Poor lung health Prolonged prolonged viral shedding recurrence respiratory Respiratory failure respiratory infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease Support symptomatic disease [DOI] 10.1007/s12098-021-04057-0 PMC 바로가기 [Article Type] Article
Severe neonatal COVID-19: Challenges in management and therapeutic approach중증 신생아 COVID-19: 관리 및 치료적 접근의 도전Case Reports Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adults age Bacterial biological samples breathing challenge Chest computed tomography chest X-rays children clearance clinical manifestation clinical manifestations complications Computed tomography consolidations contributed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical case critical cases demonstrated enoxaparin Enterobacter etiological agent immunomodulation increasingly Infant Infants intensive care interstitial interstitial pneumonia less life-threatening lung management mechanical ventilation mounted multidrug-resistant Neonatal Neonatal COVID-19 neonatal sepsis Neonate Neonates Older reported respiratory infection respiratory specimen respiratory specimens SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 RNA Sepsis serological test Serological tests Severe acute respiratory syndrome severe acute respiratory syndrome 2. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case steroid Steroids stools sustained Therapeutic approach viral replication Work of breathing [DOI] 10.1002/jmv.27472 PMC 바로가기 [Article Type] Case Reports
Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trialClinical Trial Published on 2022-04-012022-10-05 Journal: The Lancet. Haematology [Category] Fulltext, MERS, 임상, [키워드] 1:1 absence acute respiratory distress adjusted adjusted relative risk Administered adverse event age assigned average benefit Blood blood product Care caused characteristics of patient clearance Complication concealed COVID-19 pandemic Critical care deaths defined eligibility Follow-up identify Injury intention-to-treat population intravenous investigated involved IQR Lactate Liver function male median median age Mortality multicentre nine occurred Open-label outcome parallel group participant participants randomly assigned Patient phase 3 trial plasma Primary outcome pulse randomisation randomised Randomly receive receiving recruitment red blood cell reducing mortality Registered remains uncertain required Research Resuscitation risk Sample size Serious Adverse Events severity Shock Sodium chloride stratified syndrome Systolic blood pressure time tissue trauma Treatment treatment group Trial were assessed [DOI] 10.1016/S2352-3026(22)00040-0 PMC 바로가기 [Article Type] Clinical Trial
Comprehensive Treatment of Hematological Patients with SARS-CoV-2 Infection Including Anti-SARS-CoV-2 Monoclonal Antibodies: A Single-Center Experience Case SeriesAnti-SARS-CoV-2 단클론항체를 포함한 SARS-CoV-2 감염 혈액병 환자의 종합 치료: 단일 센터 경험 사례 시리즈Article Published on 2022-03-262022-09-11 Journal: Current Oncology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis antibody Antibody therapy B.1.1.529 B.1.617.2 bamlanivimab benefit best Cancer case sery Casirivimab clearance clinical clinical effectiveness Combination Comprehensive coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient delta variant Diagnosis Effectiveness exacerbated experience FIVE hematologic hematologic malignancies Hematologic malignancy Hematological malignancies high risk Hospitalization Imdevimab Including knowledge lAbel less mAbs monoclonal antibodies monoclonal antibody Mortality off-label omicron Omicron variant oxygen oxygen supplementation Patient Potential receiving reduce reduced reduction in respiratory retrospective risk SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2-infected patient Sery severe acute respiratory syndrome Coronavirus shown Sotrovimab suggested Tolerability Treatment variant [DOI] 10.3390/curroncol29040188 PMC 바로가기 [Article Type] Article
CD8 + T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and CancerCD8 + T 세포 노화: 바이러스 감염, 자가면역 장애 및 암의 빛과 그림자Review Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, 바이오마커, [키워드] Adaptive immune response addition Ageing Antigen Autoimmune Autoimmune disease Autoimmune diseases autoimmune disorder Autoimmune disorders Cancer cause caused CD28 CD28− CD57+ CD8+ T cells CD57 CD8 CD8+ Cell circulating clearance CMV condition contributing to cytotoxic function Diseases Effect Efficacy enrichment exacerbate favor function functions heterogeneous HIV immune-senescence immunological immunotherapies Immunotherapy implication IMPROVE Infection inflammaging inflammaging. life LIGHT low-grade inflammation lowering Lymphocytes memory Memory cells novel antigen novel antigens pathogen Pathogens phenotype Prevent progression reduction SARS-CoV-2 senescent shadow Stress switching T cell T cells T lymphocyte T lymphocytes the disease thymic Transformed cell transformed cells Tumor tumor microenvironment turn Vaccine vaccine efficacy Viral viral infection viral infections [DOI] 10.3390/ijms23063374 PMC 바로가기 [Article Type] Review