A Transient Increase in the Serum ANCAs in Patients with SARS-CoV-2 Infection: A Signal of Subclinical Vasculitis or an Epiphenomenon with No Clinical Manifestations? A Pilot StudySARS-COV-2 감염 환자에서 혈청 ANCA의 일시적 증가 : 임상 적 혈관염이없는 혈관염의 신호 또는 임상 적 증상이없는 에피 페노 메뉴?파일럿 연구Brief Report Published on 2021-08-292022-08-31 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] analyzed ANCA Antigen Asymptomatic asymptomatic patient asymptomatic patients Autoimmunity clinical clinical manifestations Clinical sign Clinical signs Control control subjects controls COVID-19 COVID-19 patients COVID-19 severity diagnosis of SARS-CoV-2 disease endothelial damage epiphenomenon Frequency Hospitalization Hospitalized hospitalized patient hospitalized patients immunoassay immunoassays increase increase in Infection MPO no difference no differences occur Patient patients with SARS-CoV-2 PR3 progression pulmonary involvement SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections serum serum levels severe pulmonary involvement signal significantly higher significantly lower Subclinical the patient to define Transient Trigger Vasculitis [DOI] 10.3390/v13091718 PMC 바로가기 [Article Type] Brief Report
Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19혈청 전환 및 발열은 흡입 COVID-19의 비인간 영장류 모델에서 용량 의존적Research Article Published on 2021-08-232022-09-10 Journal: PLoS Pathogens [Category] MERS, 변종, 치료기술, [키워드] 95% CI aerosol transmission age animals Asymptomatic baseline Clinical sign Clinical signs Comorbidities COVID-19 dependent on develop disease disease transmission dose dose-dependent Efficacy Evidence exposure dose Factor Factors Fever healthy humans immune response Infection infectious infectious dose inhalation limit masking median nasopharyngeal oropharyngeal swabs Probability provided public health measure public health measures resulting SARS-CoV-2 SARS-COV-2 infection Seroconversion significantly lower social distancing Spread subsequent subset TCID the median Therapeutics These data transmission of SARS-CoV-2 Vaccine Ventilation Viral viral variant virus while [DOI] 10.1371/journal.ppat.1009865 PMC 바로가기 [Article Type] Research Article
Clinical validation of an open-access SARS-COV-2 antigen detection lateral flow assay, compared to commercially available assays상업적으로 이용 가능한 분석법과 비교하여 개방 액세스 SARS-COV-2 항원 검출 측면 흐름 분석의 임상 적 검증Comparative Study Published on 2021-08-172022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, 치료제, [키워드] Adult patient Adult patients antigen detection clinical Clinical sign Clinical signs COVID-19 diagnostic Infection lateral flow meet minimum nare nasopharyngeal pandemic positive Predictive Rapid Rapid test Rapid tests reagents Result RT-qPCR SARS-COV-2 infection Signs and symptoms Symptom Symptoms WHO [DOI] 10.1371/journal.pone.0256352 PMC 바로가기 [Article Type] Comparative Study
Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model경증 및 중증 SARS-CoV-2 감염은 K18-hACE2 형질전환 마우스 모델에서 호흡기 및 장내 미생물군유전체 변화를 유도합니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect Antiviral Antiviral treatment Bacteroidete Bacteroidetes cecum change changes in characterized Clinical sign Clinical signs coronavirus COVID-19 COVID-19 pandemic death deaths declining Decreased develop disease dissimilarity dosage dose dose-dependent manner family Firmicute firmicutes groups hACE2 High dose High-dose immune system increasingly independent independent of Infection inhibitor intestinal intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice less lung Lungs M pro mice microbe microbes microbial Microbiome Model mouse presence or absence prevalent Proteobacteria respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 significantly Treatment Verrucomicrobia Viral viral infections virus with infection [DOI] 10.1128/Spectrum.00536-21 PMC 바로가기 [Article Type] Research Article
The effect of resistant hypertension on in-hospital mortality in patients hospitalized with COVID-19 Research Published on 2021-08-052022-10-05 Journal: Journal of human hypertension [Category] 치료법, [키워드] Admission adverse effect age Clinical signs concomitant disease confidence Coronavirus disease 2019 COVID-19 COVID-19 patients creatinine Features Follow-up Gender hospitalized patient hypertension hypertensive hypertensive patients in-hospital mortality increased risk independent independent predictor Infection interval IQR Laboratory lymphocyte male median age Mortality multivariable analysis Patient patients hospitalized procalcitonin Prognosis Ratio regulated renal Retrospective study risk significantly increased single-center SpO2 study population three group total mortality with COVID-19 [DOI] 10.1038/s41371-021-00591-8 [Article Type] Research
Impact of Tobacco Smoking on the Risk of COVID-19: A Large Scale Retrospective Cohort StudyObservational Study Published on 2021-08-042022-10-05 Journal: Nicotine & tobacco research : official journal of [Category] SARS, 임상, [키워드] 95% confidence interval age Analysis association attack rate Blood Group body mass index cause Clinical signs conducted coronavirus SARS-CoV-2 COVID-19 COVID-19 infection cross-sectional current had no Hospitalized Impact increased risk indicated Infection investigated IRB less lower risk mechanism median age Odds ratio outbreak paradoxical pathway Patient physiological polymerase chain recent reported Research retained risk SARS-CoV-2 SARS-CoV2 scale Seven severe disease Sex significantly lower smoker smoking smoking status Support susceptibility susceptible the disease Tobacco univariable analysis vessel [DOI] 10.1093/ntr/ntab004 PMC 바로가기 [Article Type] Observational Study
A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis빌리루빈 유래 나노의약은 폐 섬유증의 병리학적 캐스케이드를 약화시킵니다Article Published on 2021-08-012022-09-11 Journal: Biomaterials [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory Anti-inflammatory effects antioxidant antioxidants Antioxidative ARDS attenuate bile acid Bilirubin Bilirubin nanoparticles Biomarkers Bleomycin blood circulation cascade caused Clinical sign Clinical signs COVID-19 COVID-19 infection disease fibrosis histological Immune cell immune cells incidence life-threatening mice nanomedicine outbreak oxidative damage pulmonary pulmonary fibrosis reduce respiratory distress SARS-CoV-2 SARS-COV-2 infection shown syndrome the disease therapeutic options therapeutic potential [DOI] 10.1016/j.biomaterials.2021.120986 PMC 바로가기 [Article Type] Article
Intravenous, Intratracheal, and Intranasal Inoculation of Swine with SARS-CoV-2SARS-COV-2를 사용한 돼지의 정맥 내, 쇄골 내 및 비강 내 접종Article Published on 2021-07-302022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition animal model animals Antibody titer change Clinical signs collected Contact coronavirus D614G Diseases Epidemiology experiment greater group histologic Host human SARS-CoV-2 Infectious diseases inoculation intermediate hosts intranasal route intratracheal intravenous isolate Laboratory multiple coronaviruses Mutation naïve nasal/oral swab necropsy Neutralizing antibody titer New York City PCR positive pig PIGS positive rectal swab Rectal swabs reservoir reservoirs respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread Support susceptibility susceptible swine tiger tissue sample tissue samples titers Viral viral replication virus virus isolation [DOI] 10.3390/v13081506 PMC 바로가기 [Article Type] Article
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infectionRBD를 표적으로 하는 합성 나노바디는 SARS-CoV-2 감염으로부터 햄스터를 보호합니다Article Published on 2021-07-302022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] ACE2 protein animal model animal models antibody bind binding Bioavailability biochemical candidate Candidates causative agent Clinical sign Clinical signs COVID-19 domain feature form hamster hamsters high affinity high stability host cell in vitro inhibited Interaction Live virus llama mechanism medical intervention nanobodies nanobody neutralization activity Neutralizing Neutralizing antibodies offer outbreak PROTECT pseudoviruses RBD RBD-ACE2 Receptor-binding domain reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses single dose storage structure-based design sybodies sybody synthetic nanobodies synthetic nanobody therapeutic therapeutic activity Viral RNA viral RNA load virus X-ray crystallography [DOI] 10.1038/s41467-021-24905-z PMC 바로가기 [Article Type] Article
Animal Coronavirus Diseases: Parallels with COVID-19 in HumansReview Published on 2021-07-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome animal animal coronavirus caused Clinical signs complement coronavirus Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic Critical described Diagnosis disease DIVA effective vaccine genome organization handling Human humans Immunopathogenesis Intensive Novel coronavirus Outbreaks pathophysiological mechanism Perspective public health Recombination recorded Research SARS-CoV-2 subject Transmission Treatment viral shedding viruses with COVID-19 [DOI] 10.3390/v13081507 PMC 바로가기 [Article Type] Review