Complement activation – Page 6 – Communicable Diseases Research

Be aware of acute kidney injury in critically ill children with COVID-19

COVID-19에 감염된 위독한 어린이의 급성 신장 손상에 대해 알고 있어야 합니다.

Case Reports

Published on 2021-01-012022-09-11
Journal: Pediatric Nephrology (Berlin, Germany) [Category] 임상, 치료기술,

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

심층 혈액 프로테옴 프로파일링 분석은 중증 코로나19 환자와 그렇지 않은 COVID-19 환자 사이에서 혈장 단백질의 뚜렷한 기능적 특성을 밝혀냈습니다.

Article

Published on 2020-12-292022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Biomarker Blood Candidates Characteristics Clinical outcome complement Complement activation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases develop differentially expressed disease severity downstream eight Factor functional highlighting host response IMPROVE Infectious diseases interleukin interleukin-6 mortality rate Necrosis neutrophil neutrophil activation Patient patients worldwide performed plasma plasma protein Platelet potential therapeutic target potential therapeutic targets predict profiling analysis Prognosis prognostic biomarker Prognostic markers proinflammatory Protein Proteins proteome proteomic Proteomic analysis proteomics quantified reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity of COVID-19 Support T cell Tumor tumor necrosis tumor necrosis factor upstream
[DOI] 10.1038/s41598-020-80120-8 PMC 바로가기 [Article Type] Article

Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations

다양한 임상 증상에 걸쳐 SARS-CoV-2 소아에서 혈전성 미세혈관병증의 증거

Article

Published on 2020-12-082022-09-11
Journal: Blood advances [Category] MERS, SARS, 바이오마커, 진단,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection age Biomarker children children with COVID-19 clinical consequence clinical criteria clinical presentation complement Complement activation Complete coronavirus coronavirus disease Coronavirus disease 2019 creatinine criteria determine Diagnostic Criteria disease Elevation elevations endothelial damage enrolled Evidence evidence of Future healthy control Hospitalized Infection Inflammatory interquartile range IQR management median Mild MIS-C MOST Patient patients pediatric Pediatric patient plasma proportion respiratory SARS-CoV-2 SARS-COV-2 infection screened serum creatinine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease subject syndrome tested thrombotic thrombotic microangiopathy was measured
[DOI] 10.1182/bloodadvances.2020003471 PMC 바로가기 [Article Type] Article

Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients

만노스 결합 렉틴은 중환자 COVID-19 환자의 혈전증 및 응고증과 관련이 있습니다

Article

Published on 2020-12-012022-09-11
Journal: Thrombosis and haemostasis [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation amplification Blood coagulation caused Coagulation Coagulopathy Cohort complement Complement activation complications contribute correlated COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer levels develop Effect elevated events hospital ICU ICU admission Ill increased risk Inflammation initiate intensive care Laboratory testing lectin lectin pathway mannose marker MBL pathway mechanism morbidity and mortality organ dysfunction pathological thrombosis Patient Pattern recognition pharmacological plasma risk significantly higher Society subset suggested symptomatic thromboembolic Thromboinflammation Thromboprophylaxis thrombosis treated Treatment
[DOI] 10.1055/s-0040-1715835 PMC 바로가기 [Article Type] Article

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

COVID-19의 내피 손상 및 혈전성 미세혈관병증: 렉틴 경로 억제제 나르소플리맙으로 치료

Article

Published on 2020-11-012022-09-11
Journal: Immunobiology [Category] SARS, 진단, 치료법,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adverse drug reaction Adverse drug reactions anticoagulant effects ARDS Arterial thrombosis Autopsies baseline bind C-reactive protein C-reactive protein (CRP circulating compassionate use complement Complement activation complications Continuous Positive Airway Pressure control group Coronavirus-2 COVID-19 COVID-19 patient CPAP CRP during treatment effective Endothelial cell endothelial cell damage endothelial damage endothelial injury enzyme human immunoglobulin IgG4 IL-6 IL-8 Immunoglobulin Inflammation inhibit inhibitor Injury interleukin interleukin-6 interleukin-8 intubation Lactate lactate dehydrogenase LDH lectin lectin pathway life-threatening Lung injury mannan MASP-2 monoclonal antibody Mortality Narsoplimab nucleocapsid protein pathogenic Patient positive airway pressure reducing reduction reported respiratory respiratory distress Respiratory distress syndrome resulting retrospective SARS-CoV-2 Serine serine protease serum Serum IL-6 Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome-associated coronavirus-2 significantly higher survived sustained syndrome thrombosis thrombotic thrombotic event Thrombotic events thrombotic risk treat Treatment treatment for COVID-19 was used were assessed were used
[DOI] 10.1016/j.imbio.2020.152001 PMC 바로가기 [Article Type] Article

COVID-19 as an Immune Complex Hypersensitivity in Antigen Excess Conditions: Theoretical Pathogenetic Process and Suggestions for Potential Therapeutic Interventions

항원 과잉 조건에서 면역 복합 과민증으로서의 COVID-19: 이론적 병인 과정 및 잠재적 치료 개입에 대한 제안

Immunology

Published on 2020-10-212022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE-2 receptor activated Activation anti-spike antibodies Antigen antigen excess antigenic nature Asymptomatic carried Coagulation complement Complement activation complement system complex component conditions COVID-19 Critical determine develop excess Factor FIBRIN homeostasis Human immune system hypersensitivity Hypothesis hypothetical IgM and IgG immune complex immune response immune response mechanisms induce Infection inflammatory factors innate immune interfere Kawasaki-like disease lung macrophages membrane neutrophil Neutrophils occur pathology Potential Process Severe patient Spike antigen subject suggestion supported symptomatic systemic disorders therapeutic intervention thrombi tissue tissue damage vascular inflammation Viral viral infection Viral proteins virus
[DOI] 10.3389/fimmu.2020.566000 PMC 바로가기 [Article Type] Immunology

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

Immunology

Published on 2020-10-212022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

In the Crosshairs: RNA Viruses OR Complement?

Review

Published on 2020-09-292023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] Complement activation complement regulators RNA viruses viral evasion strategies Virus neutralization
[DOI] 10.3389/fimmu.2020.573583 PMC 바로가기 [Article Type] Review

Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies

로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전

Article

Published on 2020-08-012022-09-11
Journal: Human reproduction (Oxford, England) [Category] Coronavirus, 비임상,

[키워드] Activation Administered Affect age alteration Analysis Angiogenesis animal model Antiretroviral therapy approval Biomarker Biomarkers biopsy birth outcomes breath cART cause caution Cell Cell culture cells chance clinical implications clinical trial clinical trials clinically co-culture Combination complement Complement activation conception contributing to correlation COVID-19 COVID-19 pandemic Culture culture system current darunavir decidualization decrease drug candidate Drug safety dysregulation early pregnancies early pregnancy early stage early stages Effects Efficacy ELISA evaluate evaluated event Evidence evidence of Ex vivo experimental models expression Factor Factors female first trimester flow cytometry for inclusion foundation funding gestational age Health care Health care worker health care workers healthy highest highlight HIV HIV infection HIV protease inhibitor HIV protease inhibitors immune cell population immune cell populations immune dysregulation Immunohistochemical analysis immunohistochemistry impair impairment implication in vitro in vivo include Inflammation initiated lack leads Lopinavir Luminex assay Lye matter maturation mechanism media mice Migration modify mouse natural killer Natural killer cells offered once daily outcome outcomes Participation placental placentation potential mechanism pregnancies Pregnancy pregnant women prophylactically protease PROTECT quantified reduced regimen regulate reported reproductive resource Respiratory disease sacrifice Safe selective specific effect specific effects spiral spiral artery spiral artery remodeling STAT3 Stephen Support supported TANK termination of pregnancy therapeutic potential Think tank tissue transcription factor Transgender Treatment Trial trophoblast trophoblasts uterine uterine natural killer cells. Vascular viability was measured was obtained was used water were used with HIV women
[DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article

The case of complement activation in COVID-19 multiorgan impact

Article

Published on 2020-05-242023-06-15
Journal: Kidney international [Category] MERS, SARS,

[키워드] C5 inhibition Complement activation complement terminal pathway COVID-19 Kidney injury Vascular injury
[DOI] 10.1016/j.kint.2020.05.013 PMC 바로가기 [Article Type] Article