The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopesSARS-CoV-2 Delta 변이체는 주로 클래스 1 및 2 항체 에피토프에 초점을 맞춘 항체 반응을 유도합니다Article Published on 2022-06-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antibody binding antibody epitope antibody immunity Antibody Response Antibody responses antigenic Beta Beta variant binding class D614G Delta delta variant Effect elicit elicited epitope Epitopes exposure help Impact induce Infection infections K417N mRNA mRNA vaccine Mutation neutralization Neutralizing antibody response polyclonal polyclonal antibody RBD Receptor-binding domain reduce responses SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants specificity the RBD the receptor-binding domain vaccination Vaccinations Vaccine variant virus viruses [DOI] 10.1371/journal.ppat.1010592 PMC 바로가기 [Article Type] Article
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan우즈베키스탄의 임상 샘플에서 얻은 SARS-CoV-2의 게놈 서열 다양성Article Published on 2022-06-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha Amino acid amino acid substitution annotation association change clade clades clinical isolates clinical sample Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity D614G Deleterious Deletion Delta Denmark disease severity evidenced Evolution female followed by genetic diversity Genome Genomic analysis genomic change Genotype help Identified isolate isolates male Missense Missense mutation Missense mutations Mutation Nextstrain NSP Nsp12 nsp13 Nsp3 nsp4 NSP6 nucleotide Open reading frame ORF ORF7a Pathogenesis PCR-positive patient Protein reading regions Research Russia SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severity significantly SNP SNPs subclade Substitution synonymous Tashkent the Spike two group two groups USA variant variants Variation WGS whole genome sequence with COVID-19 [DOI] 10.1371/journal.pone.0270314 PMC 바로가기 [Article Type] Article
Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal AntibodiesSARS-CoV-2 Omicron BA.1 및 BA.2 변이체의 백신 유도 혈청 및 치료용 단일클론 항체에 대한 내성Article Published on 2022-06-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] AstraZeneca BNT162b2 BNT162b2 vaccine COVID-19 D614G Effectiveness Emergency use fold immunization individual Lilly LY-CoV555 mixture monoclonal monoclonal antibodies monoclonal antibody monoclonal antibody therapy mutated neutralized Neutralizing titer omicron Omicron BA.2 Omicron variants parental Regeneron REGN10933 REGN10987 remained resistance SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 significantly Spike protein Spike proteins therapeutic therapy titer titers Vaccine variant variants virus [DOI] 10.3390/v14061334 PMC 바로가기 [Article Type] Article
Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable EpitopesSARS-CoV-2 스파이크 단백질의 구조 역학: SARS-CoV-2 변이체(알파에서 오미크론까지)의 2년 후향적 분석을 통해 보존된 에피토프와 가변 에피토프 간의 초기 차이가 드러났습니다.Article Published on 2022-06-152022-09-11 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 binding ADE analyzed antibodies antibody Antibody-dependent enhancement antiviral strategy approaches bind binding circulating conformational change conserved COVID-19 infection D614G D614G mutation Delta determined by Divergence domain Dynamics epitope Epitopes Evolution facilitate facilitating antibodies flat help host cells linear mimicking molecular Molecular epidemiology Mutation N-terminal domain Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron pandemic Retrospective analysis risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 variants selected spike Spike protein the SARS-CoV-2 the spike protein Vaccine Variability variable was determined [DOI] 10.3390/molecules27123851 PMC 바로가기 [Article Type] Article
Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529신흥 SARS-CoV-2 변이체 B.1.1.529의 스파이크 당단백질의 기능적 특성Article Published on 2022-06-142022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 affinity ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 B.1.617.2 Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CP: Immunology CP: Microbiology cytopathic effects D614G decrease exhibit functional glycoprotein higher affinity immune evasion immunology Infection less Microbiology neutralization neutralization sensitivity omicron Patient prevalent processing property pseudovirus pseudoviruses relative S glycoprotein S glycoproteins S trimer S1 shedding SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus spike glycoprotein stability syncytium formation temperature TMPRSS2 TMPRSS2 expression Transmission unliganded vaccinees variant variants virion [DOI] 10.1016/j.celrep.2022.110924 PMC 바로가기 [Article Type] Article
Full-genome sequencing and mutation analysis of SARS-CoV-2 isolated from Makassar, South Sulawesi, IndonesiaArticle Published on 2022-06-102023-07-09 Journal: PeerJ [Category] COVID19(2023년), [키워드] COVID-19 D614G N439K SARS-CoV-2 whole-genome sequencing [DOI] 10.7717/peerj.13522 PMC 바로가기
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant variant of concern variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategyDNA 프라임-단백질 부스트 전략을 이용한 SARS-CoV-2 변이체 감염에 대한 고친화성 단일클론항체 유도Article Published on 2022-06-092022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha alpha and delta variants angiotensin angiotensin-converting enzyme 2 animals Antibody titers approach approved best Beta Beta variant binding ability binding affinity boost broad spectrum clone coronavirus Coverage COVID-19 COVID-19 vaccination D614G Delta delta variant DNA ELISA Emergency use Endemic epitope epitope mapping Epitopes evaluated exhibit flu Gamma generate high affinity Human angiotensin-converting enzyme 2 include induction Infection Lambda monoclonal antibodies monoclonal antibody monoclonal antibody combination Multiple neutralization neutralization potency neutralize Neutralizing antibody titer neutralizing capacity neutralizing epitope neutralizing epitopes Outbreaks PROTECT RBD Receptor-binding domain regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Spike protein the receptor-binding domain the spike protein therapeutic drug therapeutic effect therapeutic effects treat treated Treatment variant variants VoC VOCs were used Wuhan strain [DOI] 10.1186/s12929-022-00823-0 PMC 바로가기 [Article Type] Article
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo대규모 in vitro 스크리닝 및 in vivo 효과 평가를 통한 잠재적 anti-SARS-CoV-2 약물 발굴Article Published on 2022-06-012022-09-11 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug approved drug candidate caused Cell culture cisatracurium clinical clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment cytotoxicity D614G D614G variant develop drug Drug repurposing drug resistance Drug screening drugs effective Efficacy Gilteritinib hamster hamster model. hamsters HeLa cell HeLa cells human ACE2 IL-6 in vitro in vivo induce life cycle mRNA pandemic passage Postinfection promoted Prophylactic protective effect provided pulmonary viral reduced Remdesivir Salinomycin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle selected sertraline severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown suppressed the SARS-CoV-2 TNF-α transduced Treatment variety Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1007/s11427-021-2031-7 PMC 바로가기 [Article Type] Article
Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs프로테아제 억제제 Camostat Mesyalte는 인간이 조작한 소형 폐에서 야생형 SARS-CoV-2 및 D614G 바이러스 진입을 차단합니다Article Published on 2022-06-012022-09-11 Journal: Biomaterials [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3D model alveolar alveolar epithelial cell AT2 block camostat catastrophic cell line cell lines COVID-19 Culture D614G develop distal Effect epithelial epithelial cells evaluate Ex vivo highlight human lung in vitro model induce Infection inhibitor involved lentivirus lung lung epithelium maturation moderate organ organ culture organoids pandemic Pathogenesis pathogenesis of COVID-19 phenotype platform pluripotent stem cell Prevent progression Protease inhibitor provided pseudotyped real time reduced Research respiratory tract SARS-CoV-2 SARS-CoV-2 pandemic significantly the SARS-CoV-2 tissue treat type 2 alveolar epithelial cells viral entry viral infection viral infections virulent while wild type wildtype [DOI] 10.1016/j.biomaterials.2022.121509 PMC 바로가기 [Article Type] Article