Identification of Key Pathways and Genes in SARS-CoV-2 Infecting Human Intestines by Bioinformatics AnalysisOriginal Article Published on 2021-11-172022-10-28 Journal: Biochemical Genetics [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] AKT1 Analysis bioinformatics Bioinformatics analysis BUB1B caused CCNA2 COVID-19 Cytoscape database DEGs differentially expressed gene digestive tract disease Fatty liver follow-up study Gene Expression Omnibus gene expression profile Genes GEO Human identification Infectious disease KEGG KIF20A Kyoto nine Ontology pathway pathway enrichment performed PLK1 PPI Protein–protein interaction R software Research RRM2 SARS-CoV-2 SARS-COV-2 infection statistically significant supplementary material Timp1 Treatment TTK virus [DOI] 10.1007/s10528-021-10144-w PMC 바로가기 [Article Type] Original Article
Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infectionResearch article Published on 2021-11-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종, [키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread [DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article
Network-based transcriptomic analysis identifies the genetic effect of COVID-19 to chronic kidney disease patients: A bioinformatics approachResearch article Published on 2021-10-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] Actin Analysis analyzed approach ARHGEF12 Aspirin BCL2L1 bioinformatics CAV1 chronic Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 patient DEGs detect differentially expressed gene drug E2F1 EPHB2 gene signature Genetic Health high risk HSP90B1 hub protein identify infected with SARS-CoV-2 Infection Interaction investigated ITGA2B Kidney disease microRNA molecular pathways mononuclear cell Ontology pathway Patient patients PBMC Peripheral blood PPI PRKAR2B protein-protein interaction Rapamycin regulate SARS-CoV-2 Systems biology the SARS-CoV-2 therapeutic target Threats transcription factor Transcriptional signature transcriptomic transcriptomic analysis transcriptomic data TUBB1 [DOI] 10.1016/j.sjbs.2021.06.015 [Article Type] Research article
Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation네트워크 약리학, 레스베라트롤이 COVID-19 관련 과염증을 완화할 수 있음을 밝혀냄Research Article Published on 2021-09-222022-09-10 Journal: Disease Markers [Category] SARS, 유전자 메커니즘, [키워드] Analysis Anti-inflammatory Antiviral antiviral agent approach benefit bioinformatic analysis Can COVID-19 COVID-19 patients COVID-19 therapy dataset DEGs differentially expressed gene enrichment analysis followed by gene analysis Gene Expression Omnibus Gene ontology GEO GO term GO terms GSE147507 hyperinflammation IL-17 involved KEGG KEGG pathway Kyoto location network notable overlap pathway pathway enrichment Pathways pharmacological pharmacological mechanism Pharmacology Potential protein-protein interaction resveratrol SARS-CoV-2 screened signaling pathway target targets therapeutic therapy TNF signaling [DOI] 10.1155/2021/4129993 PMC 바로가기 [Article Type] Research Article
Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients특발성 폐섬유증 및 만성 폐쇄성 폐질환 환자에 대한 SARS-CoV-2 감염의 영향을 확인하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2021-09-022022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach bioinformatics Biomarker build candidate drug candidate drugs chronic obstructive chronic obstructive pulmonary disease confirmed COVID-19 case COPD coronavirus COVID-19 COVID-19 infection dataset datasets DEGs detect differentially expressed differentially expressed gene Differentially expressed genes drug molecule effective fibrosis functional Gene Expression Omnibus Gene ontology GEO GSE147507 help hub gene hub genes identify Idiopathic pulmonary fibrosis influence Interaction interactions IPF linkage molecular molecular mechanism molecular mechanisms obstructive pulmonary disease Ontology pathway Pathway analysis Patient patients performed PPI PPI network progression protein-protein interaction Protein–protein interaction protein–protein interaction (PPI). pulmonary disease pulmonary fibrosis risk factor Risk factors RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus second wave severe acute respiratory syndrome Coronavirus shared pathway shared pathways statistical System biology the epidemic the SARS-CoV-2 virus therapeutic transcription factors transcriptomic analysis underlie were used [DOI] 10.1093/bib/bbab115 PMC 바로가기 [Article Type] Article
Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes기존 제2형 당뇨병과 SARS-CoV-2 감염에 대한 시너지적 복잡성의 분자적 통찰력 확인Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] activities Analysis analyzed approaches association bioinformatics BIRC3 caused Cell Comorbidities Comorbidity conditions contributing to COVID-19 COVID-19 outbreak CREB3L1 cytokine cytokine receptor DEGs detect determine diabete diabetes differentially expressed gene Differentially expressed genes Disease progression drug drug candidate drug candidates Drug molecules enrichment enrichment analyses evaluated expressed Factor followed by FOSL1 Functional enrichment analysis Genetic genetic determinant genetic factors global public health Health identify identifying IL-17 IL1B Interaction IRF1 islet cell KLF11 let-7b-5p lung epithelium cell lung epithelium cells microRNA MicroRNAs miR-1 miRNA miRNAs MME molecular overlapped pancreatic pancreatic islet Pathways Patient PBMC PBMCs PPI prevalent protein-protein interaction protein–protein interactions receptor Research SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 significant pathway significant pathways synergistic T2D TFS the disease therapeutic intervention TNF transcription factor transcription factors transcriptomic data Type type 2 diabete type 2 diabetes [DOI] 10.1016/j.compbiomed.2021.104668 PMC 바로가기 [Article Type] Article
A network-based systems biology approach for identification of shared Gene signatures between male and female in COVID-19 datasetsResearch article Published on 2021-08-182022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, 신약개발, [키워드] absence Affect Analysis app approach Biomarker category CDK1 CDK2 Cell Comorbidities Comorbidity coronavirus country COVID-19 COVID-19 virus dataset datasets death DEGs DNA Doxorubicin drug E2F1 female FN1 gene signature greater Hub-proteins Human identify Interaction involved KEGG pathway KLF5 L-alanine male maturation medication Mild miRNA moderate Mortality mortality rate Novel coronavirus Ontology Oocyte other disease overlapping Pathway enrichment analysis peripheral blood cell PPARG PPI network Respiratory system retrieved risk factor RNAseq robust Robust voom roscovitine SARS-CoV-2 Serine severe symptom Sex Sex-specific biomarkers SP1 Still suggested SUMO2 Symptoms Systems biology Tamoxifen therapeutic agent TP53 treat UBC Vaccine women [DOI] 10.1016/j.imu.2021.100702 [Article Type] Research article
Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndromeRNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다Article Published on 2021-08-012022-09-11 Journal: IET systems biology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained [DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology