Risk of Adverse Drug Events Following the Virtual Addition of COVID-19 Repurposed Drugs to Drug Regimens of Frail Older Adults with PolypharmacyArticle Published on 2020-08-102022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] added addition ADE Adverse adverse drug events caused Chloroquine Combination Comorbidity COVID-19 demonstrated Determination develop distribution drug drug interaction drug regimen drug regimens drugs elderly event Frequency HCQ Hydroxychloroquine increase increase in Infection Long magnitude mandatory medication novel coronavirus disease offer Older Older adults participant performed polypharmacy positive control Program Repurposed drug Result risk risk of COVID-19 Risk scores score Simulation was determined with COVID-19 [DOI] 10.3390/jcm9082591 PMC 바로가기 [Article Type] Article
Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patientsResearch Paper Published on 2020-08-062022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] 95% CI Admission age analyzed Asymptomatic Asymptomatic carrier Asymptomatic COVID-19 asymptomatic infected patients asymptomatic infection asymptomatic infections asymptomatic patients Chest Chest CT China clinical feature confirmed cases coronavirus disease cough Course COVID-19 COVID-2019 Cox regression analysis Cox regression model Determination develop diagnosed died discharged disease effective antiviral treatment epidemiological evaluate examined fatigue female Fever history of smoking Hospitalization illness onset infected patient infected patients information initially asymptomatic patient intensive care laboratory data lymphopenia male Mild symptom nucleic acid nucleic acid test observation onset of symptom onset of symptoms outcome Patient patients pharyngalgia positive Predictive value predictor Pregnant woman presence or absence Prognosis pulmonary disease remained Retrospective study risk factor Risk factors severe pneumonia smoking Symptom symptoms onset underlying diseases was performed [DOI] 10.7150/ijms.47576 PMC 바로가기 [Article Type] Research Paper
Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 95% CI absence addition administration of hydroxychloroquine Admission aerosol-generating procedures allergy analyzed Anesthesia antibody approved ARMS assigned balanced randomization blind Cancer Cantabria carried CDC Cell Chemoprophylaxis clinical Clinical data clinically coated Committee comparator Comparator group computer-generated control group Controlled Controlled clinical trial Controlled trial coronavirus COVID COVID-19 criteria CURB current detect Determination disease dissemination double blind double-blind dropout rate Efficacy Efficacy and safety element ELISA kit Emergency Endocrine estimate Ethics Euroimmun Evidence evidence of Germany GRADE greater group Health Health authority health-care healthcare personnel Healthcare professional healthcare professionals heart heart failure help hematological high risk hospital Hydroxychloroquine hydroxychloroquine sulfate hygiene Hypothesis ICU IDT IgA IgG IgM and IgG immune immunodeficiency in vitro incidence include Infection inhibit intensive care unit Intervention investigator kidney lactation liver measure Measures Medicine Negative PCR neurological New York number observation period outcome participant PCR performed Personal protective equipment Placebo positive positive SARS-CoV-2 PCR positive serology Pregnancy presenting Prevalence Primary outcome probes product professional Prophylaxis Prospective PROTECT Protective protocol Psychiatric randomised randomised controlled trial randomization Randomized randomized trial RCT receive recruitment reduce reported responsible risk RT-PCR Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR sequence Seroconversion serological serology severity Significant single center single-center study social distancing Spain Spanish Standard Statistical power status Study protocol subject Support Symptom symptomatic and asymptomatic Tablet Takara Taking Tamoxifen Transmission Treatment two-tailed university Vaccine virus website while [DOI] 10.1186/s13063-020-04400-4 PMC 바로가기 [Article Type] Letter
Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matricesResearch Article Published on 2020-06-012022-10-28 Journal: Arthritis Research & Therapy [Category] Coronavirus, SARS, [키워드] alternative method Analysis applied Blood Clinical use comparison Concentration COVID-19 patients demonstrated Determination Direct evaluated HCQ high accuracy Hydroxychloroquine Inflammatory measurement MONITOR Patient patients performed plasma Precision Quality control repeated reported reproducibility Result rheumatic disease rheumatoid arthritis serum serum and plasma serum sample SLE SLE patient SLE patients Standard of care systemic lupus erythematosus therapeutic drug Treatment treatment effects Variation Whole blood whole blood sample [DOI] 10.1186/s13075-020-02211-1 PMC 바로가기 [Article Type] Research Article
Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and DiagnosticsArticle Published on 2020-05-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Analysis analyzed antigenicity base substitution bases Cluster Clustering COVID-19 Deletion Determination diagnostics drugs Effect Effectiveness epidemiological Evolution genomes immune response Immunity Immunological memory immunology indication Metadata molecular Molecular epidemiology NCBI database pandemic pathogen performed Phylogenetic phylogenetically predicted presenting primer binding site Protein Region reveal SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 sequence selected target region variant variants Variation virulence virus virus variant detection while whole genome sequence [DOI] 10.3390/jcm9061615 PMC 바로가기 [Article Type] Article
Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging짧은 2',3'-사이클릭 인산염 함유 RNA의 게놈 전체 식별 및 노화 조절Research Article Published on 2019-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adapter ligation adenosine advent aging Analysis biogenesis can not capture characterized cleavage cytidine cytoplasmic Degradation Determination effort event Evolution expressed expression expression level expression levels functional hidden identify ligation reaction mRNAs ncRNAs next-generation sequencing technology non-coding RNA Non-coding RNAs pathway phosphate physiological produced random reduction regulated Regulation remained ribonuclease RNA RNA molecule RNA molecules RNA-Seq RNAs rRNAs sequence standard RNA tissues Transcriptome tRNAs [DOI] 10.1371/journal.pgen.1008469 PMC 바로가기 [Article Type] Research Article
Expression profile analysis of 5-day-old neonatal piglets infected with porcine DeltacoronavirusResearch Article Published on 2019-04-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] affected alteration Analysis Animal experiment caused Cell Clinical symptoms correlated Critical death decrease Determination diarrhea differential expression differentially expressed differentially expressed gene digestion Endoplasmic reticulum expressed gene expressions Fabp1 FABP3 fatty fatty acid metabolism Host immunohistochemical staining Infection infections mechanism metabolic pathway metabolism modulate mRNA mRNA expression profile Neonatal Novel coronavirus nucleus organelle Pathogenesis pathway Porcine deltacoronavirus PPAR signaling PPAR signaling pathway Protein protein 3 provided real-time RT-PCR receptor regulated Result Signaling signaling molecule signaling pathway signaling pathways viral growth weight loss [DOI] 10.1186/s12917-019-1848-2 PMC 바로가기 [Article Type] Research Article
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labelingResearch Article Published on 2019-01-112022-10-31 Journal: eLife [Category] Coronavirus, MERS, [키워드] assist Biotin breadth build caused Cell common cold Complete complex complexes comprehensive analysis Contact Coronaviral coronavirus Coronaviruses Critical cytoplasm demonstrated Determination disease enzyme Factor Factors genetic code help Host host cell host cells host protein host proteins Human infect Infection infections Interaction involved kill knowledge membrane MERS microenvironment Mild molecular mouse nose and throat Other Pathways platform positive-sense RNA virus Protein proximal proximity labeling question replicase complex replication complex researcher RNA virus RTC scientist severe disease short-lived starting point Symptom target therapeutic intervention These viruses translation translation initiation Transport turn Vesicular Transport Viral proteins viral RNA synthesis virus virus infection virus particles Virus-host interaction waste disposal [DOI] 10.7554/eLife.42037 PMC 바로가기 [Article Type] Research Article
Determination of Ferret Enteric Coronavirus Genome in Laboratory FerretsDispatch Published on 2017-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Complete coronavirus Coronaviruses Determination enteric enteric infections ferret Ferret enteric coronavirus ferret systemic coronavirus ferrets Genome genome sequence genus Alphacoronavirus identity Laboratory Next-generation sequencing nucleotide sequence RNA Strains viruses [DOI] 10.3201/eid2309.160215 PMC 바로가기 [Article Type] Dispatch
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증Research Article Published on 2016-09-072022-09-17 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray [DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article