downregulated – Page 6 – Communicable Diseases Research

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

Dexamethasone은 심각한 COVID-19에서 미성숙 호중구와 인터페론 프로그래밍을 조절합니다

Article

Published on 2021-11-152022-09-10
Journal: Nature Medicine [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료법,

An epigenome-wide DNA methylation study of patients with COVID-19

COVID-19 환자의 후성유전체 DNA 메틸화 연구

Article

Published on 2021-11-012022-09-11
Journal: Annals of human genetics [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] Above analyses Analysis biological processes can be used CHN2 CHST15 conducted COVID-19 COVID-19 patient COVID-19 patients CPLX2 CRHR2 DCAKD disease severities DNA DNA methylation downregulated duplicates eliminating EpiC Epigenetic epigenetic regulation expression function functions Genes GNAI2 GNAS GNG7 healthy subject healthy subjects HECW1 highest highly pathogenic hub genes HYAL1 Illness severity Illumina immune system investigated methylated MIR510 molecular mechanism molecular mechanisms pathophysiology pathway Pathways patients with COVID-19 PDE11A PPI PRKAG2 PRKCZ progression promoter region public health Regulation SARS-CoV-2 SARS-COV-2 infection selected Sequencing severe group Signal transduction SMG6 were used
[DOI] 10.1111/ahg.12440 PMC 바로가기 [Article Type] Article

Heat shock protein 70 could enhance porcine epidemic diarrhoea virus replication by interacting with membrane proteins

Research Article

Published on 2021-10-302022-10-28
Journal: Veterinary Research [Category] Coronavirus, MERS,

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

SARS-CoV-2는 바이러스 전파를 촉진하기 위해 RIPK1 활성화를 촉진합니다

Article

Published on 2021-10-182022-09-11
Journal: Cell Research [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution blocked caused Cell Biology cell death cells CNS conserved Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines death downregulated EGFR Evidence evidence of examined facilitate Factor global pandemic Host host defense host defense response human lung organoid human lung organoids Inflammation inhibition inhibitor Innate immunity Interaction Italy lead lombardy lung lung viral load Mechanisms of disease mediator Mortality Nsp12 Proinflammatory cytokine proinflammatory cytokines promote promoted public health reduced Replication respiratory RIPK1 RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus subset systemic inflammatory response the SARS-CoV-2 therapeutic therapeutic option threonine Transcription transcriptional transgenic mice Treatment treatment of COVID-19 variant Viral viral entry Viral load viral propagation
[DOI] 10.1038/s41422-021-00578-7 PMC 바로가기 [Article Type] Article

Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients

전사체 분석, 코로나19 환자 눈물 각질화에 관여하는 유전자 발현 증가

Article

Published on 2021-10-062022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] affected Analysis B cell B cell response Cell signaling Chain Reaction conjunctivitis coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Diagnostic markers downregulated evidenced functional Gene Expression Gene regulation healthy individual healthy individuals healthy subject healthy subjects increased expression indicated induce involved keratinization mRNA expression next generation sequencing NGS ocular Patient patients with COVID-19 polymerase chain polymerase chain reaction Predictive markers Prognostic markers Real time reverse transcription polymerase chain reaction recent reverse transcription SARS-CoV-2 several gene several genes Signaling statistically Symptom tears time Transcriptome upregulated viral infection
[DOI] 10.1038/s41598-021-99344-3 PMC 바로가기 [Article Type] Article

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

순환하는 microRNA 프로필은 입원 환자의 COVID-19 중증도를 예측합니다

Clinical Trial

Published on 2021-10-012022-09-11
Journal: Translational research : the journal of laboratory [Category] MERS, SARS, 바이오마커, 임상,

[키워드] 95% CI Analysis assist AUC Biomarker Biomarkers C-reactive protein C-reactive protein (CRP Chain Reaction circulating circulating miRNA circulating miRNA profile clinical ward clinical wards correlated Critical care Critically ill critically ill patients D-dimer Deterioration disease disease severity downregulated dysregulated evaluate hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients ICU ICU patient ICU Patients intensive care intensive care unit laboratory parameter Laboratory parameters leukocyte management microRNA miRNA miRNA profiling miRNA signature miRNAs multicenter multicenter study Nasopharyngeal swab nonsurvivor nonsurvivors operator pandemic Patient patients PCR polymerase polymerase chain reaction positive predict predictive models profile Quantitative recruited reverse transcription RT-qPCR SARS-CoV-2 severity of COVID-19 signature Spain Specific stratified survivor Survivors the disease variable vital status was performed
[DOI] 10.1016/j.trsl.2021.05.004 PMC 바로가기 [Article Type] Clinical Trial

Intestinal expression of ACE2 in mice with high-fat diet-induced obesity and neonates exposed to maternal high-fat diet

고지방식이로 인한 비만과 산모 고지방식에 노출된 신생아에서 ACE2의 장 발현

Article

Published on 2021-10-012022-09-11
Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] SARS, 치료기술,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease ACE2 ACE2 mRNA ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 controls coronavirus coronavirus disease COVID-19 digestive disease downregulated evaluate the effect examined expressed expression global health Health High-fat diet Infection intestinal intestinal macrophage intestinal macrophages intestine investigated involved Macrophage macrophages mice mRNA expression Neonatal Neonate Neonates Novel coronavirus novel coronavirus disease obesity offspring opposite outcome Patient patients with COVID-19 proportion receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus Symptom
[DOI] 10.1016/j.nut.2021.111226 PMC 바로가기 [Article Type] Article

Controlled Ovarian Hyperstimulation Protocol in Infertile Patients During the COVID-19 Pandemic

Physiology

Published on 2021-09-272022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells

Research Article

Published on 2021-09-082022-10-28
Journal: Virulence [Category] COVID-19, SARS,

Dysbalance of ACE2 levels – a possible cause for severe COVID-19 outcome in COPD

ACE2 수준의 불균형 - COPD에서 심각한 COVID-19 결과의 가능한 원인

Article

Published on 2021-09-012022-09-11
Journal: The journal of pathology. Clinical research [Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Arterial hypertension CD147 change changed changes in chronic lung disease chronic lung diseases chronic obstructive chronic obstructive pulmonary disease circulating cofactor controls COPD coronavirus Course COVID-19 datasets decrease determined by Donor downregulated elevated enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epithelial cells expression expression levels EZR ezrin fibrosis furin Gene Expression Healthcare system Healthcare systems healthy control histological analysis hypertension infection mechanism Localization lung Lung disease lung tissue obstructive pulmonary disease outcome Patient patients plasma Plasma levels plasma samples Protective pulmonary arterial hypertension pulmonary disease pulmonary fibrosis pulmonary hypertension putative receptor quantitative PCR reduced Region risk factor Risk factors RNA sequencing sACE2 SARS-CoV-2 SARS-COV-2 infection scRNAseq Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Single-cell RNA sequencing susceptibility tissue expression tissue sample tissue samples TMPRSS2 TMPRSS2 expression transmembrane serine protease transmembrane serine protease 2 viral entry virus were used
[DOI] 10.1002/cjp2.224 PMC 바로가기 [Article Type] Article