Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-MethyltransferasemRNA 캡 구아닌 N7-메틸트랜스퍼라제를 표적으로 하는 잠재적인 SARS-CoV-2 항바이러스제의 식별 및 평가Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] analyzed antiviral activity antiviral agent approach assays binding binding site Cell Compound COVID-19 COVID-19 pandemic dot blot Drug discovery ENCODE enzyme FIVE Fluorescence fluorescence anisotropy Fluorescence assay guanine HPLC identification identify inhibitor Inhibitor screening inhibitory effect Inhibitory effects insight involved mRNA novel nsp14 SARS-CoV-2 screened Structure tested therapeutic intervention therapeutic interventions to define [DOI] 10.1016/j.antiviral.2021.105142 PMC 바로가기 [Article Type] Article
Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 MethyltransferaseArticle Published on 2021-08-302022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] approach classical complex COVID-19 pandemic ENCODE Enzymes inhibitor innate immune Methylation methyltransferase non-canonical RNA nucleotide positive RNA RNA genome SARS Coronavirus SARS-CoV-2 substrate tested viral infections virus [DOI] 10.3390/v13091722 PMC 바로가기 [Article Type] Article
Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90SARS-CoV-2 Orf9b의 인산화는 TOM70의 2개 결합 부위에 대한 표적화 및 Hsp90 모집을 조절합니다Article Published on 2021-08-262022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association B.1.1.7 binding binding site C-terminal domain cascade causative agent chaperone chaperones characterized complex coronavirus COVID19 decrease domain ENCODE expression Glutamate Hsp90 IFN-I indicate infected cells inhibit interferon interferons involved leads mechanism Mitochondria mitochondrial mitochondrial outer membrane N-terminal N-terminal domain Orf9b pandemic Phosphorylation position Protein Proteins recruitment reduced regulated respiratory SARS-CoV-2 SARS-CoV-2 genome Serine severe acute respiratory syndrome Coronavirus Signaling Site target targeting TOM70 TPR type I interferon type I interferons variant variant of concern Viral Viral protein [DOI] 10.3390/ijms22179233 PMC 바로가기 [Article Type] Article
Persistence of Anti-S Titre among Healthcare Workers Vaccinated with BNT162b2 mRNA COVID-19Article Published on 2021-08-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] AIFA anti-S anti-S-RBD antibodies antibody approved authorization BNT BNT162b2 mRNA BNT162b2 mRNA vaccine consequence COVID-19 COVID-19 pandemic detectable domain drug Effective vaccines elderly ENCODE evaluate HCW HCWs Health healthcare worker Healthcare workers immunological protection Infection Italian Messenger RNA mRNA mRNA vaccine nucleoside-modified RNA operator operators Pfizer Phase I Protective antibody public health systems Safe SARS-CoV-2 SARS-CoV-2 antibody serological significantly lower spike glycoprotein the SARS-CoV-2 titre vaccination Vaccine worker [DOI] 10.3390/vaccines9090947 PMC 바로가기 [Article Type] Article
Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human PrimatesArticle Published on 2021-08-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome animal models antibody approved binding boost candidate Cellular immune response cellular response coronavirus COVID COVID-19 CureVac ENCODE etiological agent humoral immune response immunogenicity injected intramuscular vaccination investigated mRNA mRNA vaccine neutralizing antibody NHP non-human primate non-human primates PBS platform pre-fusion primate Protein SARS-CoV-2 SARS-CoV-2 S shown T cell response vaccination Vaccine vaccine candidate Vaccines volunteers was performed [DOI] 10.3390/v13081645 PMC 바로가기 [Article Type] Article
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300Research Article Published on 2021-08-172022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome bat coronaviruses Cell chymotryptic digestion cleavage coronavirus coronavirus disease COVID-19 cysteine cysteines demonstrated dimerization drug targets ENCODE experiment gel filtration glutaredoxin glutathionylation inhibit M pro main protease Modification monomer mutant oxidative stress pathophysiology polyprotein polyproteins pp1a pp1ab protease Protein provide reactive reducing regulated Replication required responsible restored Reversible SARS-CoV-2 susceptible therapeutic interventions thioltransferase ultracentrifugation undergo viral replication [DOI] 10.1128/mBio.02094-21 PMC 바로가기 [Article Type] Research Article
Deep geometric representations for modeling effects of mutations on protein-protein binding affinityResearch Article Published on 2021-08-042022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, [키워드] addition Amino acid approach binding affinity change dataset datasets deep develop drug design Effect effort ENCODE experiments feature functional geometric in silico Approach Interaction labor-intensive modeling Mutation mutations predict Protein protein complex Protein design protein-protein interaction Proteins RBD Research SARS-CoV-2 antibody structures the binding affinity the receptor-binding domain the S protein three-dimensional structure time-consuming Topology [DOI] 10.1371/journal.pcbi.1009284 PMC 바로가기 [Article Type] Research Article
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses코로나바이러스의 오픈 리딩 프레임(ORF)에서 게놈 순서와 관련성을 체계화Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Accessory Accessory genes accessory protein accessory proteins agent analyzed Cluster complex conserved Coronaviridae coronavirus coronavirus disease coronavirus disease-2019 CoV CoVs effort ENCODE envelope focus Frame gene clusters Genes Genome genomes genomic genus greater mechanisms membrane naming nucleocapsid Open reading frame ORF ORF gene ORF3a ORF3b ORF3c ORF3d ORF5 ORFs pandemic Phylogeny polypeptide Protein Proteins Referral RNA genome RNA genome. RNA virus RNA viruses SARS-CoV-2 structural proteins the Spike transcriptional translational viral genome [DOI] 10.1016/j.meegid.2021.104858 PMC 바로가기 [Article Type] Article
Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19FDA 승인 약물로부터 SARS-COV-2 엔도 리보 뉴 클레아 제 (ENDOU)의 잠재적 억제제의 확인 : COVID-19에 대한 치료제를 찾기위한 약물 재구성 접근법Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site Amino acid amino acid residues antiviral drug approach approved binding binding affinity binding free energies binding free energy calculated catalytically causative agent Clinical efficacy Comparative Compound COVID-19 diabete diabetes dose drug Drug development Drug repurposing ENCODE endonuclease EndoU enzyme essential amino acid FDA free energies Glisoxepide IC50 Idarubicin identification in silico inhibitor intermolecular interaction leukemia life cycle molecular molecular dynamic simulation molecular dynamics monophosphate Nsp15 performed predicted required responsible ribonucleotide SARS-CoV-2 selected Simulation study Structural analysis suggested surface area therapeutic therapeutic option treat Treatment uridine uridine monophosphate Vaccine Viral Virtual screening Virus life cycle [DOI] 10.1080/07391102.2020.1775127 PMC 바로가기 [Article Type] Article
SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate ImmunitySARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.Article Published on 2021-07-232022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법, [키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis [DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article