epitope mapping

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Alanine Analysis antibody Antibody detection antibody epitope antibody epitopes antibody repertoire Antibody Response Antibody responses Antibody-dependent enhancement antiviral antibodies antiviral antibody Asymptomatic caused circulating clinical outcomes colds common-cold Control controls coronavirus coronavirus disease Coronavirus disease 2019 coronavirus strains Coronaviruses correlation Course covariates COVID-19 COVID-19 patient COVID-19 severity Critical cross-react cross-reactive antibody cross-reactivity cytomegalovirus death deep Demographic variables detect diagnostic diagnostics disease disease severity distress enzyme-linked immunosorbent assays epitope epitope mapping Epitopes exacerbate examination exhibited explain females Fever functional Gender generate gold herpes simplex herpes simplex virus Herpes Simplex Virus 1 Hospitalization Hospitalized hospitalized patients human coronaviruses human sera humans humoral Humoral response humoral responses hypothese hypotheses immune immunogenicity incidence individual individuals infect infected with SARS-CoV-2 Infection infections interactions Isolation knowledge machine machine-learning male mapped Mild Mutagenesis Neutralizing Neutralizing antibodies neutralizing antibody not need notable nucleoprotein ORF1 outcome outcomes Patient patient cohort peptide peptides performed predicted probe Profiling Protein proteome proteomes raise rationale required respiratory respiratory distress Respiratory system response responses reveal SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 proteome Science screened sensitivity Sequence conservation sera serological Serological assay severe acute respiratory syndrome Coronavirus severe COVID-19 severe infections severity severity of COVID-19 specificity Spike protein stratified strength suggested target targets tested the antibody response the SARS-CoV-2 the spike protein Therapeutics Therapies two groups understanding Vaccine Vaccines Viral virus
[DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article