highly pathogenic – Page 6 – Communicable Diseases Research

An Update on Animal Models for Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Countermeasure Development

Microbiology

Published on 2021-11-082022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus, United Kingdom

Article

Published on 2021-11-012023-05-31
Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자,

[키워드] Avian Influenza cetaceans first detection H5N8 highly pathogenic respiratory infections systemic infection terrestrial carnivores United Kingdom viruses zoonoses
[DOI] 10.3201/eid2711.211225 PMC 바로가기

An epigenome-wide DNA methylation study of patients with COVID-19

COVID-19 환자의 후성유전체 DNA 메틸화 연구

Article

Published on 2021-11-012022-09-11
Journal: Annals of human genetics [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] Above analyses Analysis biological processes can be used CHN2 CHST15 conducted COVID-19 COVID-19 patient COVID-19 patients CPLX2 CRHR2 DCAKD disease severities DNA DNA methylation downregulated duplicates eliminating EpiC Epigenetic epigenetic regulation expression function functions Genes GNAI2 GNAS GNG7 healthy subject healthy subjects HECW1 highest highly pathogenic hub genes HYAL1 Illness severity Illumina immune system investigated methylated MIR510 molecular mechanism molecular mechanisms pathophysiology pathway Pathways patients with COVID-19 PDE11A PPI PRKAG2 PRKCZ progression promoter region public health Regulation SARS-CoV-2 SARS-COV-2 infection selected Sequencing severe group Signal transduction SMG6 were used
[DOI] 10.1111/ahg.12440 PMC 바로가기 [Article Type] Article

Development of a recombinant vaccine containing a spike S1-Fc fusion protein induced protection against MERS-CoV in human DPP4 knockin transgenic mice

Article

Published on 2021-10-302022-11-01
Journal: Journal of virological methods [Category] Coronavirus, MERS,

[키워드] addition alum adjuvant antigen-specific neutralizing antibody baculovirus BALB/c mice BSL, biosafety level CEF, chicken embryo fibroblast cells Chinese hamster CHO, Chinese hamster ovary coronavirus demonstrated development Dipeptidyl peptidase-4 DPP4 effective ELISA, enzyme-linked immunosorbent assay Extracellular family Coronaviridae Fc fragment Fc, fragment of crystalline Fragment of crystalline (Fc) molecule fused fusion protein genus Betacoronavirus highly pathogenic human DPP4 humoral immune response Humoral immunity IgG IgG4 immunogenicity inflammatory cell infiltration inoculated lack MERS-CoV MERS-CoV infection MERS-CoV, Middle East respiratory syndrome coronavirus MERS, Middle East respiratory syndrome mice Middle East Middle East respiratory syndrome Coronavirus Neutralizing antibodies PBS, phosphate-buffered saline PBST, phosphate-buffered saline in 0.05 % Tween 20 PCR, polymerase chain reaction PFU, plaque-forming unit Protective Protein Proteins RBD, receptor-binding domain respiratory syndrome coronavirus RLU, relative light unit S1 subunit SARS-CoV, severe acute respiratory syndrome coronavirus secretion SFM, serum-free medium Spike protein therapeutic transgenic mice Vaccine vaccine candidate Vaccine development viral challenge viral outbreak virus
[DOI] 10.1016/j.jviromet.2021.114347 PMC 바로가기 [Article Type] Article

Innate Immunity Evasion Strategies of Highly Pathogenic Coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2

Microbiology

Published on 2021-10-292022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells

Pharmacology

Published on 2021-10-252022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] accompanied Affect Anti-inflammatory Antiviral antivirals assessment Calu-3 Calu-3 cell candidate CCL5 CD40L cell line cellular entry chemokine clinical study comparable Concentration coronavirus CoV COVID-19 COVID-19 therapeutics CXCL10 CXCL9 cytokine cytokine secretion Cytokine storm derivatives disease drug Duration of infection Effect elevated exhibited Extract fraction growth growth factor highly pathogenic Human human lung IC50 IL-13 IL-1β IL-6 IL-8 IL1B IL6 immune immunomodulatory function immunomodulatory properties in vitro in vivo Inflammatory response inhibited inhibiting innate immune response MERS-CoV modulation non-toxic oligomerization Particle PDGF Pelargonium pelargonium root extract (EPs® 7630) Phytomedicine Post-infection pro-inflammatory cytokine pro-inflammatory gene Prodelphinidin pseudovirus purine reduced reducing Regulation root SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 propagation separated shown significantly symptom severity TNF-α TNFAIP3 upper respiratory upregulation Viral load viruses
[DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology

Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain

SARS-CoV-2 게놈에서 COVID-19 사망률 위험에 대한 게놈 차원의 연관성 분석은 브라질 균주의 P.1과 함께 국소화되는 SARS-CoV-2 스파이크 단백질의 돌연변이를 식별합니다

Article

Published on 2021-10-012022-09-11
Journal: Genetic epidemiology [Category] SARS, 변종, 치료기술, 치료제,

[키워드] Affect Alter Amino acid analyses Analysis analyzed approach association Brazil can not center change coding sequences Containment Control COVID-19 mortality COVID-19 patient database databases defined disease control driven by ENhance Follow-up Frequency Genome-wide association studies Genome-wide association study genome-wide significance geographical regions GISAID GISAID database GWAS highly pathogenic host susceptibility identify improvement Improvements in viral information loci locus Logistic Logistic regression methodology Mortality Mutation occur p value p values P.1 pathogenic pathogenicity remained risk S2 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 spike protein sequence variation sequenced single-stranded Spike protein starting strain submitted symptom severity target host cells the SARS-CoV-2 the SARS-CoV-2 genome variant viral entry viral genome viral infectivity viral strain virus WGS whole-genome sequencing
[DOI] 10.1002/gepi.22421 PMC 바로가기 [Article Type] Article

Molecular evolutionary characteristics of SARS‐CoV‐2 emerging in the United States

Research Article

Published on 2021-09-202022-10-04
Journal: Journal of medical virology [Category] SARS, 변종, 진단,

Challenges of Storage and Stability of mRNA-Based COVID-19 Vaccines

Review

Published on 2021-09-172022-10-28
Journal: Vaccines [Category] COVID-19,

MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity

Research Article

Published on 2021-09-142022-10-29
Journal: mBio [Category] COVID-19,

[키워드] activity acute respiratory syndrome Antiviral antiviral activity Antiviral effect antiviral response caused cell lines cellular cellular RNA changes in complexes conserved coronavirus CoVs CRISPR-Ca cytoplasmic decrease described Helicase help highly pathogenic highly pathogenic coronavirus highly pathogenic CoVs human CoV human CoVs humans identify immunoprecipitation in viral indicated Infection Interaction involved life-threatening MERS-CoV MERS-CoV infection metabolism Middle East modulation MOV10 mutant N protein nucleocapsid nucleocapsid protein overexpression pathogen Pathogenesis Protein required Respiratory disease respiratory syndrome coronavirus RNA SARS-CoV-2 significantly increased Structure therapeutic targets understanding Viral RNA viral RNAs virus titer Virus-host interactions viruses wild-type
[DOI] 10.1128/mBio.01316-21 PMC 바로가기 [Article Type] Research Article