Variant of Concern-Matched COVID-19 Convalescent Plasma Usage in Seronegative Hospitalized Patients혈청 음성 입원 환자에서 우려 일치 COVID-19 회복기 혈장 사용의 변형Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 28-day mortality advanced disease Adverse reaction Adverse reactions affecting age anti-spike monoclonal antibodies anti-spike monoclonal antibody Anti-viral therapy Blood donors CCP collected convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma Delta Efficacy hospital Hospitalized hospitalized COVID-19 patient hospitalized patient Immunocompromised Immunocompromised patient Immunocompromised patients infused IQR Italian mAb mAbs median age mortality rate NAbs Neutralizing antibodies neutralizing antibody omicron outcome patients protective immune response Randomized controlled trial recipient reported rescued SARS-CoV-2 seronegative severe COVID-19 Support Two patient two patients Usage variants variants of concern VoC VOCs were recorded [DOI] 10.3390/v14071443 PMC 바로가기 [Article Type] Article
Influence of influenza vaccine and comorbidity on the evolution of hospitalized COVID-19 patientsCase Reports Published on 2022-06-242022-10-05 Journal: Medicina clínica [Category] 임상, [키워드] 95% CI Admission age association Comorbidity Comorbilidad conducted coronavirus disease COVID COVID-19 Edad electronic medical records evaluate Evolution had no heart failure hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Increasing influence Influenza influenza vaccine material Mortalidad Mortality multivariate logistic regression Older age outbreak Pacientes hospitalizados Patient risk risk factor Risk factors vaccination Vaccine Vacuna antigripal. with COVID-19 [DOI] 10.1016/j.medcli.2021.06.003 PMC 바로가기 [Article Type] Case Reports
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 PatientsObservational Study Published on 2022-06-212022-10-04 Journal: Antimicrobial Agents and Chemotherapy [Category] 임상, [키워드] 50% effective concentration accumulates clearance clinically collected Concentration coronavirus disease covariate COVID-19 COVID-19 patient COVID-19 patients daily dose dependent on described distribution dose dosing regimen Effectiveness elimination half-life evaluated explain glomerular filtration rate GS-441524 Hospitalized hospitalized COVID-19 patient Hypoxemia identify IMPROVE in vitro metabolite mixed-effects model Patient patients pharmacokinetic pharmacokinetics plasma plasma concentration Population Probability reduced Remdesivir renal function therapy Treatment Variability Volume was performed [DOI] 10.1128/aac.00254-22 PMC 바로가기 [Article Type] Observational Study
Associations of Clinical Factors and Blood Groups With the Severity of COVID-19 Infection in Makkah City, Saudi ArabiaObservational Study Published on 2022-06-212022-10-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] 임상, [키워드] ABO ABO blood groups association Asthma Blood Blood Group chronic kidney diseases city clinical Clinical characteristics clinical factor confirmed COVID-19 case congestive heart failure correlation cough COVID-19 COVID-19 infection COVID-19 patient cross-sectional Deceased Diabetes Mellitus diagnosed disease distress distribution expected Factor Fever Frequency group higher infectivity Hospitalized hospitalized COVID-19 patient hypertension infected patient Infection Kingdom Makkah material medical record Ministry of Health Mortality no significant difference Patient patients PCR phenotype Pneumonia positive positive PCR Prevalence Respiratory failure retrieved Rh blood groups Risk factors risk of death Saudi Arabia severity of COVID-19 significantly increased significantly lower specialist Symptom Symptoms syndrome tested Western region with COVID-19 [DOI] 10.3389/fcimb.2022.870096 PMC 바로가기 [Article Type] Observational Study
Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico멕시코에서 SARS-CoV-2에 감염된 환자의 산화 스트레스 바이오마커 및 사망률과의 연관성Article Published on 2022-06-172022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI absorbance alteration analyzed antioxidant association AUC baseline characteristics Biomarker Biomarkers characteristic Characteristics collected Combination COVID-19 COVID-19 patients determine died Evidence evidence of expression healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients Imbalance immune system individual infected with SARS-CoV-2 involved knowledge lead malondialdehyde MDA Mortality oxidative stress oxygen oxygen radical Patient patients with COVID-19 reactive oxygen species reactive oxygen specy receiver operating characteristic redox status ROC ROS SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples TAC total antioxidant capacity were assessed [DOI] 10.1155/2022/1058813 PMC 바로가기 [Article Type] Article
Symptomatic, clinical and biomarker associations for mortality in hospitalized COVID-19 patients enriched for African Americans아프리카계 미국인을 위한 입원 COVID-19 환자의 사망률에 대한 증상, 임상 및 바이오마커 연관성Article Published on 2022-06-172022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] African African American African Americans age American Analysis analyzed Asian association AST Biomarker Cancer cardiac disease Cohort collected Comorbidities Comorbidity COPD correlated COVID-19 creatinine CRP D-dimer death demographics determine diabetes Diabetes Mellitus diarrhea disease severity elevated elevated liver enzymes Ethnicity European fatigue ferritin focus Frequency Gender Glucocorticoids high mortality Hispanic hospital Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hypertension Immunosuppression increased risk Inflammatory biomarker laboratory data large cohort LAT Latinx liver enzyme liver enzymes Lymphocytes male Male sex mechanical ventilation Mortality mortality rates Multivariate analysis New York non-survivor Older age organ Organ failure outcome outcomes Patient patients hospitalized predictor Prevent procalcitonin progression race required SARS CoV-2 SARS-CoV-2 Sex Shortness of breath significant variable significant variables significantly study population subsequent Symptom troponin [DOI] 10.1186/s12879-022-07520-1 PMC 바로가기 [Article Type] Article
Death and invasive mechanical ventilation risk in hospitalized COVID-19 patients treated with anti-SARS-CoV-2 monoclonal antibodies and/or antiviral agents: A systematic review and network meta-analysis protocol항SARS-CoV-2 단클론항체 및/또는 항바이러스제로 치료받은 입원한 COVID-19 환자의 사망 및 침습적 기계 환기 위험: 체계적인 검토 및 네트워크 메타 분석 프로토콜Article Published on 2022-06-172022-09-11 Journal: PLoS ONE [Category] MERS, meta-analysis, 변종, 진단, 치료제, [키워드] (risk ratio 95% confidence interval acceptance Analysis anti-SARS-CoV-2 Antiviral Antiviral agents approach assessment assumption best claimed Comorbidities confidence COVID-19 pandemic COVID-19 patient Critically ill cumulative death development diagnosed effect size Evidence high risk hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunocompromised indicate intensive care intensive care unit Intervention Invasive mechanical ventilation Local Meta-analysis monoclonal antibody Mortality network Network meta-analysis NMA nucleic acid nucleic acid amplification nucleic acid amplification test occur occurred outcome Patient plan PROSPERO protocol Randomized controlled trial Randomized controlled trials randomized trial randomized trials Registration reported risk risk of bia risk of infection risk ratio RoB 2 sensitivity analysis Stata Statistical Software statistical statistical significance Steroids systematic review treated Trial variants variants of concern [DOI] 10.1371/journal.pone.0270196 PMC 바로가기 [Article Type] Article
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patientsResearch article Published on 2022-06-072022-10-05 Journal: Immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accompanied Admission analyzed baseline basophils blood sample cell type changes changes in conserved courses COVID-19 COVID-19 patient Cytometry discharge disease disease resolution element elevated Frequency healthy individual heterogeneous hospital discharge hospitalized COVID-19 patient immune Immune cell immune cell signaling immune response immunological immunological change increases in Infection longitudinal analysis mass outcome pathophysiological Patient patients hospitalized phosphorylated Pneumonia recovery reduced reduction in Regulatory T cell Respiratory failure reveal Sepsis severe SARS-CoV-2 Signaling single-cell T cell trajectory while with COVID-19 [DOI] 10.1016/j.immuni.2022.06.004 [Article Type] Research article
Severity of infection with the SARS-CoV-2 B.1.1.7 lineage among hospitalized COVID-19 patients in Belgium벨기에 코로나19 입원환자 중 SARS-CoV-2 B.1.1.7 계통 감염 심각도Observational Study Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 95% CI adjusted Admission age Analysis B.1.1.7 B.1.1.7 lineage B.1.1.7 variant Belgium Characteristics circulating conducted confounder confounders COVID-19 disease COVID-19 disease severity death Factors graph hospital Hospital stay Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Host ICU ICU admission in-hospital mortality increased risk Infection intensive care manifestation no difference Observational cohort study occupancy rate Other other variables Pathogenesis pathogenesis of COVID-19 Patient performed progression regression analysis risk SARS-CoV-2 B.1.1.7 SARS-CoV-2 variant SARS-CoV-2 variants Selection bias Sensitivity analyses Sequencing severe COVID-19 severe COVID-19 disease severity significantly significantly higher strain Strains Surveillance the mean the patient the SARS-CoV-2 transferred vaccination variable variant [DOI] 10.1371/journal.pone.0269138 PMC 바로가기 [Article Type] Observational Study