An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimerSARS-CoV-2의 N-말단 도메인을 표적으로 하는 항체는 스파이크 삼량체를 파괴합니다Article Published on 2022-06-012022-09-12 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Adaptive immunity antibody Antigen B cell binding Cell cell-to-cell spread Cluster coronavirus COVID-19 Culture disrupt dominant epitope functional Genetic human Angiotensin-converting enzyme human antibody response IGHV1-24 immunoglobulins immunology inhibited mice MOST N-terminal domain neutralizing antibody NTD Protective Protective antibody Protein provide receptor recognize representing S protein SARS-CoV-2 SARS-CoV-2-neutralizing antibody Sequencing single B cell specificity spike trimer the receptor-binding domain the S protein the SARS-CoV-2 trimer Trimers virion Virology virus [DOI] 10.1172/JCI159062 PMC 바로가기 [Article Type] Article
Data on immunogenicity and reactogenicity to COVID-19 vaccination among patients receiving maintenance dialysisData article Published on 2022-06-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, [키워드] acute respiratory syndrome assays cellular Cellular immune response Complete coronavirus coronavirus disease COVID-19 COVID-19 vaccination dialysis dose Effectiveness ELISPOT exclusion General population Hemodialysis homologous humoral immune response immune response Immunity immunoassay immunoglobulins increased risk interferon-γ Microparticle morbidity and mortality Patient Peritoneal dialysis produced reactogenicity receiving regimen SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine single dose T cells tested the vaccine trials vaccination [DOI] 10.1016/j.dib.2022.108271 [Article Type] Data article
Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds항바이러스 화합물의 스크리닝을 위한 시험관내 홍역 바이러스 보급 분석의 용도 변경Review Published on 2022-05-292022-09-11 Journal: Viruses [Category] 치료제, [키워드] Adults Antiviral antiviral assay Antiviral assays antiviral efficacy approved can not children Compound contagious contribute Coverage COVID-19 pandemic described dissemination effective evaluate fusion inhibitory peptide immunocompromised individuals immunoglobulins in vitro individual Infant inhibit inhibitory Intervention intravenous lifted limit Measle measles measles virus morbidity and mortality outbreak Outbreaks pandemic pandemic response box peptide populations present reactive Remdesivir repurposing respiratory virus responsible resulting resurgence risk Safe Screening Standard of care therapeutic interventions Treatment vaccination Vaccine [DOI] 10.3390/v14061186 PMC 바로가기 [Article Type] Review
Miller Fisher syndrome after COVID-19 vaccination: Case report and review of literature코로나19 백신 접종 후 밀러 피셔 증후군: 증례 보고 및 문헌 검토Review Published on 2022-05-202022-09-11 Journal: Medicine [Category] 변종, [키워드] adverse effect albuminocytologic dissociation Analysis areflexia Ascending paralysis association Ataxia Blood cerebrospinal fluid Complete Complication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccinations diagnosed Diagnosis Diplopia discharge ENhance febrile febrile illness first dose Fisher syndrome Guillain-barrè syndrome hypertensive immunoglobulins Infection intravenous latency lower limb lower limbs male management Miller Miller fisher syndrome moderate Nerve conduction ophthalmoplegia paralysis pathophysiology Physical examination Physiotherapy pregabalin radiological reduced reported required Research resolution of symptom routine Sinovac Socioeconomic Factors the patient triggers vaccination Vaccinations variant viral infection viral infections [DOI] 10.1097/MD.0000000000029333 PMC 바로가기 [Article Type] Review
Seroconversion panels demonstrate anti-SARS-CoV-2 antibody development after administration of the mRNA-1273 vaccine혈청전환 패널은 mRNA-1273 백신 투여 후 항-SARS-CoV-2 항체 개발을 보여줍니다Article Published on 2022-05-112022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration analyzed anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response anticipated collected COVID-19 disease facilitate first vaccination healthcare worker IgG Immunity immunoglobulins Immunological response individual injection Moderna mRNA-1273 vaccine older subjects overcome pandemic Panel positive positive response pre-vaccination SARS-CoV-2 second dose Seroconversion Seroconversion panel Serological assay significantly subject tested the vaccine vaccination Vaccine viral disease [DOI] 10.1016/j.vaccine.2022.04.006 PMC 바로가기 [Article Type] Article
Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limitsSARS-CoV-2에 대한 항체가를 결정하기 위한 혈청학적 검사의 탐색적 평가: 적절성 및 한계Multicenter Study Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Analysis analyzed antibody Antibody titer Antibody titers appropriateness can be used Definition detect determine diagnostic diagnostic test diagnostic tests effective Effectiveness Elecsy Elecsys evaluated Health highlight IgA immunoassay Immunoglobulin immunoglobulins Infection International international standard International standards laboratory data limit limitation Luminex xMAP multicenter multiplex Multiplex assay multiplicity RBD resulting Roche S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 test SARS-CoV-2 tests selected serological serological test Serological tests serum serum sample serum samples Siemen Spike protein Standard subject subjects the SARS-CoV-2 the WHO titer to define vaccination Variability WHO [DOI] 10.1002/jcla.24363 PMC 바로가기 [Article Type] Multicenter Study
Efficacy of high-dose intravenous immunoglobulin in severe and critical COVID-19: A retrospective cohort study중증 및 중증 코로나19에서 고용량 정맥 면역글로불린의 효능: 후향적 코호트 연구Article Published on 2022-05-012022-09-12 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality adjusted administration age analyses Analysis analyzed APACHE II score Care chronic respiratory disease COVID-19 COVID-19 disease COVID-19 severity Critical critical COVID-19 patients dysregulated immune response early administration Efficacy evaluate group High-dose hospital ICU ICU admission immunoglobulins immunomodulatory therapy IMPROVE in-hospital mortality initial intensive care Intravenous immunoglobulin invasive ventilation less Linear regression management mechanical ventilation Mortality negativity obesity outcome outcomes Oxygen requirements Patient patient selection performed reduced retrospective cohort study Retrospective study secondary Severe COVID-19 Infection significantly standard treatment supplemental oxygen Ventilation [DOI] 10.1016/j.intimp.2022.108615 PMC 바로가기 [Article Type] Article
Detection of antibodies against SARS-CoV-2 both in plasma pools for fractionation and in commercial intravenous immunoglobulins produced from plasma collected in Italy during the pandemic분획을 위한 혈장 풀과 전염병 기간 동안 이탈리아에서 수집된 혈장에서 생산된 상업용 정맥 면역글로불린 모두에서 SARS-CoV-2에 대한 항체 검출Article Published on 2022-05-012022-09-11 Journal: Blood transfusion = Trasfusione del sangue [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Amplification assay anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody authority collected Concentration Control detection determine Elecsy Grifol Grifols Immunoglobulin immunoglobulins intravenous Intravenous immunoglobulin investigated Italian Italian region Italy lombardy material nucleocapsid protein official pandemic plasma positive produced qualitative detection Quantitative reactive reactivity Receptor binding domain Release Roche SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 spike tested [DOI] 10.2450/2021.0055-21 PMC 바로가기 [Article Type] Article
False positive Herpes Simplex IgM serology in COVID-19 patients correlates with SARS-CoV-2 IgM/IgG seropositivityCOVID-19 환자의 위양성 단순 헤르페스 IgM 혈청 검사는 SARS-CoV-2 IgM/IgG 혈청 양성과 상관관계가 있습니다Article Published on 2022-05-012022-09-12 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adding Adsorption cause caused correlation COVID-19 COVID-19 patient COVID-19 patients diagnosed enzyme-linked immunosorbent False positive Herpe herpes simplex Herpes simplex IgM Heterologous IgM IgM/IgG immunoassay Immunoglobulin immunoglobulins inhibiting Interference Laboratory features molecular non-specific Patient Pneumonia Polyvinylpyrrolidone positive reactive SARS-CoV-2 serological serology Significant simplex tested Viral pneumonia [DOI] 10.1016/j.diagmicrobio.2022.115653 PMC 바로가기 [Article Type] Article
The humoral response to SARS-COV-2 vaccines in MS patients: A case series exploring the impact of DMT, lymphocyte count, immunoglobulins, and vaccine type다발성경화증 환자에서 SARS-COV-2 백신에 대한 체액성 반응: DMT, 림프구 수, 면역글로불린 및 백신 유형의 영향을 탐구하는 사례 시리즈Article Published on 2022-05-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Affect age antibody association B-cell case sery CD19 Cell Certain disease correlation COVID19 depleting detectable disease disease phenotype disorder DMT dose Exploratory analysis females fumarate Gender group humoral Humoral response Hypogammaglobulinemia immune response immunoglobulins immunological immunological characteristics lymphocyte Lymphocyte count lymphocyte counts lymphopenia Mild Multiple multiple sclerosis no differences Patient performed positive positive patient positive patients Quantitative response to vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV2 seroconversion rate seroconversion rates Spike protein subgroup subgroups tested the spike protein therapy vaccination Vaccine vaccine response Vaccines variable verification [DOI] 10.1016/j.msard.2022.103785 PMC 바로가기 [Article Type] Article