Combining immunomodulators and antivirals for COVID-19 – Authors’ replyCOVID-19에 대한 면역조절제와 항바이러스제의 결합 - 저자의 답변Comment Published on 2021-06-012022-09-11 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 치료제, [키워드] Antiviral COVID-19 immunomodulator [DOI] 10.1016/S2666-5247(21)00115-4 PMC 바로가기 [Article Type] Comment
Combining immunomodulators and antivirals for COVID-19COVID-19에 대한 면역 조절제와 항바이러스제의 결합Comment Published on 2021-06-012022-09-11 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 치료제, [키워드] Antiviral COVID-19 immunomodulator [DOI] 10.1016/S2666-5247(21)00114-2 PMC 바로가기 [Article Type] Comment
Scrutinizing Coronaviruses Using Publicly Available Bioinformatic Tools: The Viral Structural Proteins as a Case StudyMolecular Biosciences Published on 2021-05-242022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Analysis antibody antiviral molecule assumed beta-coronavirus Bioinformatic cause caused contribute COVID-19 DeepView molecular graphics program disease Effect effort envelope protein glycoprotein immunomodulator impair knowledge life-threatening Lung infection macromolecule membrane protein MERS-CoV molecular nucleocapsid protein other organ pandemic Protein SARS-CoV SARS-CoV-2 Spike protein stimulate structural protein the SARS-CoV-2 virus tissues Vaccine development viral spike virus viruses [DOI] 10.3389/fmolb.2021.671923 PMC 바로가기 [Article Type] Molecular Biosciences
Possible Beneficial Actions of Caffeine in SARS-CoV-2SARS-CoV-2에서 가능한 카페인의 유익한 작용Review Published on 2021-05-222022-08-31 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] Action addition adenosine airway airway smooth muscle angiotensin Angiotensin-converting enzyme Anti-inflammatory antiviral activity Awareness caffeine chymotrypsin complex Consumption COVID-19 COVID-19 pandemic domain drug Effect effective fatigue host cell host cells immunomodulator immunomodulatory effects IMPROVE in silico in vitro in vivo models increase Infection inhibiting inhibitor mechanism molecular molecular docking molecular dynamics Proteases receptor receptor antagonist Receptor-binding domain reduce reduce viral replication required SARS-CoV-2 smooth muscle specific treatment suggested Treatment Viral viral replication wakefulness [DOI] 10.3390/ijms22115460 PMC 바로가기 [Article Type] Review
Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease매일 고용량 경구 비타민 D 요법이 코로나19 환자의 염증 표지자에 미치는 영향Randomized Controlled Trial Published on 2021-05-202022-08-13 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료법, [키워드] added addition adjunctive Pulse D therapy analysed Biochemistry BMI COVID 19 COVID-19 COVID-19 patient CRP difference disease Diseases dysregulation evaluated ferritin group groups High dose Hypovitaminosis D IL6 immune dysregulation immunomodulator Impact Inflammatory marker inflammatory markers LDH marker Microbiology N/L ratio outcomes Pathogenesis Patient Pulse D therapy randomised reduced reducing reduction Seven Side effects significantly standard treatment standard treatment alone statistical significance subject Therapeutic improvement therapy Treatment protocol treatment protocols two group two groups variable Vitamin D vitamin D level with COVID-19 [DOI] 10.1038/s41598-021-90189-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 and IL-6: Why vitamin D (probably) helps but tocilizumab might notCOVID-19 및 IL-6: 비타민 D(아마도)가 도움이 되지만 토실리주맙이 도움이 되지 않는 이유Review Published on 2021-05-152022-09-12 Journal: European journal of pharmacology [Category] 진단, [키워드] Administered administration antagonists Anti-inflammatory anti-inflammatory action antibody block conducted COVID-19 COVID-19 patient Cytokine storm Deleterious demonstrated effective Effects help IL-6 IL-6 antagonist Immune cell immunomodulator immunomodulatory effect interleukin involved Lower modulate monoclonal outcomes positive presenting pro-inflammatory pro-inflammatory action receptor receptors reducing reported Safe the cytokine storm therapeutic agent therapeutic option therapeutic target Tocilizumab Trial Vitamin D while [DOI] 10.1016/j.ejphar.2021.174031 PMC 바로가기 [Article Type] Review
β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19Pharmacology Published on 2021-05-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate activating Activation acute respiratory syndrome adhesion molecules Affect affected Anti-inflammatory anti-inflammatory property Antiviral beta-caryophyllene Bioavailability candidate candidate drug cannabinoid cascade caused chemokines Clinical studies Complication coronavirus COVID-19 Cytokines dietary disease Eicosanoids functional G-protein identifying immune modulation Immunity immunomodulator immunomodulators immunomodulatory properties Infection Inflammation Inflammatory mediators inhibit investigated Ligand modulate modulating modulation molecular mechanisms natural natural products Nuclear receptors pandemic Pathogenesis pharmacokinetic pharmacological pharmacological mechanism Physicochemical properties plants preventive measures Protective public health emergency receptor receptors response SARS-CoV-2 selective signaling pathway signaling pathways target therapeutic therapeutic effect therapeutic potential therapeutic strategy therapeutic target tissue Toxicity Treatment Trinity unique [DOI] 10.3389/fphar.2021.590201 PMC 바로가기 [Article Type] Pharmacology
Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19Immunology Published on 2021-05-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] activity approach attack Bacteria cellular immunity COVID-19 database Defense Demonstrating Diseases displaying effective elicit Glycosides highlight humoral immune system immunomodulation immunomodulator Including Infection Isolated management mechanism mechanisms microorganism modulate molecule MOST natural nonspecific Phytoconstituents plant plants Potential potential therapy reported Research researcher responsible Safe searched therapeutic potential Traditional Chinese medicine Viral diseases viral infections virus [DOI] 10.3389/fimmu.2021.637553 PMC 바로가기 [Article Type] Immunology
Association Between Treatments and Short-Term Biochemical Improvements and Clinical Outcomes in Post-Severe Acute Respiratory Syndrome Coronavirus-2 Inflammatory Syndrome중증 후 급성 호흡기 증후군 코로나바이러스-2 염증 증후군의 치료와 단기 생화학적 개선 및 임상 결과 사이의 연관성Observational Study Published on 2021-05-012022-09-12 Journal: Pediatric critical care medicine : a journal of th [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome Administered analyzed benefit biochemical biologic agent C-reactive protein changes in children clinical clinical guideline clinical marker Clinical outcome clinical trial clinician collected combinations Coronavirus-2 Course decrease determine Effect Evidence Guidance identify Immunoglobulin immunomodulator improvement Inflammation Inflammatory Inflammatory marker lack linear Lymphocyte count measurement over Patient pediatric Platelet Propensity score receive recommendation respiratory robust Steroids study period syndrome treated Treatment treatment guideline were used [DOI] 10.1097/PCC.0000000000002728 PMC 바로가기 [Article Type] Observational Study
Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)Perspective Published on 2021-04-282022-10-04 Journal: Immunotherapy [Category] MERS, SARS, 신약개발, [키워드] Abstract acute respiratory syndrome Anti-inflammatory cardiovascular disease characterized combination therapy coronavirus COVID-19 Cytokine storm diabete diabetes Dipeptidyl peptidase-4 DPP-4 inhibitors Drug repurposing dysregulated immune response Evidence homeostasis immunomodulation immunomodulator immunomodulators immunomodulatory properties immunomodulatory property increasingly inhibitor inhibitors modulate modulation pathophysiology patients with diabete Prevent prevent disease progression pro-inflammatory cytokine pro-inflammatory mediators progression Regulation reported SARS-CoV-2 severe coronavirus disease shown synergistic the cytokine storm Therapeutic approach Treatment Type type 2 diabetes VIDPP-4i virulence Vitamin D [DOI] 10.2217/imt-2020-0349 PMC 바로가기 [Article Type] Perspective