B 0 AT1 Amino Acid Transporter Complexed With SARS-CoV-2 Receptor ACE2 Forms a Heterodimer Functional Unit: In Situ Conformation Using Radiation Inactivation AnalysisOriginal Research Published on 2021-05-132022-10-31 Journal: Function (Oxford, England) [Category] COVID-19, SARS, [키워드] 6M17 accompanied ACE2 acid Amino acid amino acid transporter angiotensin-converting enzyme-2 apical membrane approach AT1 B0AT1 coexpressed complex component conformation contribute COVID-19 COVID-19 patients dose Enterocyte expressed expression form functional Gut human tissues indicated Interaction intestine linear magnitude membrane membrane vesicle membranes mitigate molecular docking molecular weight Neutral neutral amino acid transport obligatory outbreak Particles persistence physiological purified Radiation radiation inactivation reported SARS-CoV-2 SARS-CoV-2 receptor small intestine sodium-dependent transport Symptom translational Transport transporter treat variant virion [DOI] 10.1093/function/zqab027 PMC 바로가기 [Article Type] Original Research
Antiviral and Anti‐Inflammatory Treatment with Multifunctional Alveolar Macrophage‐Like Nanoparticles in a Surrogate Mouse Model of COVID‐19Full Paper Published on 2021-05-122022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] acting aggregation‐induced emission derivative alveolar Antiviral antiviral efficiency applied biomimetic nanoparticles caused clinical clinically coronavirus coronavirus disease COVID‐19 COVID‐19 cytokine cytokine absorption cytokine levels decrease early stage ENhance facilitate host cell inactivation Infection Inflammation lung damage Macrophage management Medicine membranes mice Model mouse multifunctional multimodal therapy murine nanoparticle neutralization pandemic photothermal inactivation progression Proinflammatory cytokine proinflammatory cytokines receptor receptors reduce reducing regimen regimens reported respiratory tract risk significant survival advantage surface receptor surrogate therapeutic therapeutic strategy Transmission Treatment virus worsening [DOI] 10.1002/advs.202003556 PMC 바로가기 [Article Type] Full Paper
Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study임신 결과와 SARS-CoV-2 감염: 스페인 산과 응급 그룹 연구Article Published on 2021-05-072022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] addition association both group both groups carried Cohort coronavirus COVID-19 COVID-19 symptoms delivery difference disease disorder Emergency evaluated Factors group hypertensive iatrogenic incidence increase in increased risk infected patient infected patients infected with SARS-CoV-2 Infection information maternal complications medical records membrane membranes multivariate analyses observational study outcome outcomes PCR-negative PCR-positive perinatal outcomes Pneumonia pre-eclampsia predisposition pregnancies Pregnancy pregnant women Premature premature birth Prematurity preterm births preterm deliveries preterm delivery prospective observational study Registered rupture rupture of membranes SARS-CoV-2 severe pre-eclampsia Spanish thrombotic event univariable venous was collected women [DOI] 10.3390/v13050853 PMC 바로가기 [Article Type] Article
Viability of SARS-CoV-2 in river water and wastewater at different temperatures and solids content다양한 온도 및 고형물 함량에서 강물 및 폐수에서 SARS-CoV-2의 생존 가능성Article Published on 2021-05-012022-09-11 Journal: Water research [Category] SARS, 치료기술, [키워드] adjusted assumption carried COVID-19 COVID-19 patient COVID-19 transmission Determining discharged effort environmental condition exacerbated excrete Faeces filtered highlight increases in log lowest membranes microbial nonlinear regression pandemic Patient persistence Plaque assay plaque assays Quantitative raised Regression model remained required risk Risk assessment SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus temperature Urine Variability viability wastewater water [DOI] 10.1016/j.watres.2021.117002 PMC 바로가기 [Article Type] Article
Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19Immunology Published on 2021-04-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” activated Adaptive immunity chemokine COVID-19 cytokine Cytokine storm Factor hyperinflammatory state IL-1 inhibitor innate immune response Innate immunity interferon regulatory factor interleukin-1 Involvement irak4 IRF5 kinase Ligand M1 macrophages membranes microbial infection morbidity and mortality NF-κB Pellino-1 plasma potential therapy Proinflammatory cytokine receptor required SARS-CoV-2 signaling pathway synergistic TLR transcription factors [DOI] 10.3389/fimmu.2021.638446 PMC 바로가기 [Article Type] Immunology
In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2Article Published on 2021-03-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 beta-coronavirus bind binding binding affinity binding energy Biochemistry cellular cellular receptor complex Computational biology and bioinformatics Coronaviridae coronavirus coronavirus disease Coronavirus-2 COVID-19 Critical demonstrated drug expressed facilitate functional host cell host cell receptor in silico inhibit Interaction Lung epithelial cells management mechanism membranes Mutation occurred pandemic performed Protein–protein interaction receptor-binding motif responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein spike glycoprotein Spread the receptor-binding domain Treatment viral genome viral infection [DOI] 10.1038/s41598-021-86380-2 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by SelinexorResearch Published on 2021-03-252022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] affinity cause Cell cells cellular cellular damage characterization COS-7 cells COVID-19 cytotoxicity disease drug candidate Endoplasmic reticulum examined highest highly pathogenic Host host protein identify inhibit inhibitor interact Interaction lysosomal mechanism membrane membranes over-expressed pathogenic pathogenicity Protein Proteins purification Rae1 Ranbp2 Result reveal SARS-CoV-2 SARS-CoV-2 protein selinexor subcellular localization supplementary material tested the SARS-CoV-2 the SARS-CoV-2 genome Toxicity XPO1 [DOI] 10.1186/s13578-021-00568-7 PMC 바로가기 [Article Type] Research
Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients—A Report of 10 CasesCase Series Published on 2021-03-122022-11-01 Journal: Case Reports in Nephrology [Category] COVID-19, [키워드] Analysis asymmetric baseline bilateral pneumonia Biomarker Blood carried Case series case sery Cellulose characteristic Course COVID-19 Diagnosis dialysis died disease drug effective evaluate favor hemodiafiltration Hemodialysis Hospital admission Hospitalization Hyperinflammatory IL-6 immunomodulatory effect Infection Inflammatory Inflammatory mediators less maintenance membrane membranes moderate outcome parameter Patient patients with SARS-CoV-2 Pneumonia positive predominant radiological reduce reduction in report required role SARS-CoV-2 severe pneumonia storm suggested susceptible systemic inflammation targeting tested the cytokine storm the disease the patient therapeutic therapeutic approaches therapeutic option those who survived variety [DOI] 10.1155/2021/5575928 PMC 바로가기 [Article Type] Case Series
Coronavirus-Induced Host Cubic Membranes and Lipid-Related Antiviral Therapies: A Focus on Bioactive PlasmalogensCell and Developmental Biology Published on 2021-03-122022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] alteration Anti-viral antiviral therapy Biomarker cardiometabolic disorder coronavirus Coronavirus infection correlation COVID-19 COVID-19 patients cubic cubic membrane deficiency enzyme ether focus host cell host cells humans IMPROVE infected individuals Infection lipid metabolism lung membrane membrane fusion membrane-bound protein membranes MERS-CoV Modification modulate obesity organism Patient plasmalogen Prophylactic provoke receptors Replication required SARS-CoV SARS-CoV-2 SARS-CoV-2 infections severity suggested susceptibility TEM therapeutic Treatment type 2 diabete Virus-host interaction [DOI] 10.3389/fcell.2021.630242 PMC 바로가기 [Article Type] Cell and Developmental Biology
SARS-CoV-2 in Pregnancy—The First Wave임신 중 SARS-CoV-2—첫 번째 물결Article Published on 2021-03-052022-09-10 Journal: Medicina [Category] SARS, 치료기술, [키워드] abortion Admission Asymptomatic carried caused Cesarean section cesarean sections Complication Contact contact with coronavirus Coronavirus infections cough COVID-19 Critical Critical illness deaths disease environmental exposure evaluate fetal FIVE gestation growth headache highlight hospital Hospitalized indication indications induction of labor infectious labor material maternal deaths maternity hospital membranes mild illness MOST Nasopharyngeal swab nine Obstetric positive Pregnancy pregnancy complications pregnancy outcome Pregnant woman pregnant women Preterm birth preterm labor public health emergency retrospective RT-PCR rupture rupture of membranes SARS virus SARS-CoV-2 SARS-COV-2 infection severe or critical illness severity Stillbirth the disease threatened abortion Transmission vertical transmission virus Wave women [DOI] 10.3390/medicina57030241 PMC 바로가기 [Article Type] Article