Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19Research article Published on 2022-07-012022-10-05 Journal: Clinical gastroenterology and hepatology : the off [Category] 유전자 메커니즘, [키워드] activity adjusted alanine aminotransferase Analysis approach association body mass index Causal cohorts coronavirus disease correlation COVID-19 death demonstrated disease Evidence examined Factor Factors fibrosis Genome-wide association study identify increase indicated mendelian randomization Meta-analysis NAFLD nonalcoholic fatty liver Nonalcoholic Fatty Liver Disease obesity Odds ratio pandemic performed question relationship Result risk risk factor score serum severe COVID-19 Single nucleotide polymorphism steatosis UK Biobank data Waist circumference [DOI] 10.1016/j.cgh.2022.01.045 [Article Type] Research article
Mendelian randomization study on the causal effects of COVID-19 on childhood intelligenceCOVID-19가 아동기 지능에 미치는 인과적 영향에 대한 멘델식 무작위 배정 연구Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, [키워드] 95% confidence interval Affect analyses Analysis anaplastic causal link change childhood childhood intelligence condition Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Decline declines demonstrated Effect European evaluate the effect Genetic genetic susceptibility genetic variants Genome-wide association study GWAS Hospitalized identify increased risk individual lung Lungs mendelian randomization metaplastic Odds ratio organ systems other organ other organs pathogenic resulting risk factor simple mode variant was used weighted median weighted mode [DOI] 10.1002/jmv.27736 PMC 바로가기 [Article Type] Article
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severityResearch article Published on 2022-07-012022-10-05 Journal: EBioMedicine [Category] 신약개발, 유전자 메커니즘, 임상, [키워드] adverse effect African applied approach clinical investigation Colocalization complex complications conducted coronavirus disease COVID-19 COVID-19 severity COVID-19 treatments drug drug target drug targets Effect ENTPD5 European Europeans event Evidence FCRL3 finding funding genetics GWAS highlight ICAM1 ICAM5 immune system information mendelian randomization Multi-ancestry OAS1 Odds ratio other disease populations Protein protein targets provide provided recent reduce replicated risk sensitivity analysis SERPINA1 severity suggested target targets transcript Trial [DOI] 10.1016/j.ebiom.2022.104112 [Article Type] Research article
Whole-genome sequencing reveals host factors underlying critical COVID-19전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제, [키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing [DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article
Associations of sleep and circadian phenotypes with COVID-19 susceptibility and hospitalization: an observational cohort study based on the UK Biobank and a two-sample Mendelian randomization studyObservational Study Published on 2022-06-132022-10-05 Journal: Sleep [Category] 임상, [키워드] 95% CI 95% confidence interval addition analyses Analysis calculated causal link CIs Cohort cohort study conducted coronavirus disease COVID-19 COVID-19 hospitalization COVID-19 susceptibility decrease Diseases Effect Evidence Genetic Habitual Hospitalization hospitalized COVID-19 increased risk Insomnia Intervention IVW mendelian randomization MR analyses MR-Egger multivariable observation Observational cohort study outcome outcomes phenotype risk risk ratio RRs selected severe COVID-19 Sleep Support supported susceptibility Symptom UK biobank weighted median Weighting with COVID-19 [DOI] 10.1093/sleep/zsac003 PMC 바로가기 [Article Type] Observational Study
Genetic Landscape of the ACE2 Coronavirus ReceptorACE2 코로나바이러스 수용체의 유전적 지형Meta-Analysis Published on 2022-05-032022-09-11 Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases [DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis
Hepatitis B infection is causally associated with extrahepatic cancers: A Mendelian randomization studyArticle Published on 2022-05-012023-06-11 Journal: EBioMedicine [Category] B형 간염, Fulltext, [키워드] Cancer genetics HBV mendelian randomization SNPs [DOI] 10.1016/j.ebiom.2022.104003 PMC 바로가기
Celiac Disease and the Susceptibility of COVID-19 and the Risk of Severe COVID-19: A Mendelian Randomization StudyObservational Study Published on 2022-05-012022-10-05 Journal: Clinical and Translational Gastroenterology [Category] 임상, [키워드] 2-sample MR Analysis Cohort conducted confounding factors coronavirus disease COVID-19 COVID-19 susceptibility demonstrated disease identify mendelian randomization MR study multivariate logistic regression observational study Odds ratio Patient performed risk risk factor severe COVID-19 significantly suggested susceptibility UK biobank [DOI] 10.14309/ctg.0000000000000480 PMC 바로가기 [Article Type] Observational Study
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patientsShort communication Published on 2022-04-012022-10-05 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied association class correlation COVID-19 COVID-19 hospitalization Critically ill genetic marker Genome GWAS Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients independent initiative instrumental variable mendelian randomization obesity objective Patient platform reported Research design Result risk risk factor shown T2D type 2 diabete type 2 diabetes was performed [DOI] 10.1016/j.metabol.2022.155156 [Article Type] Short communication
Causal associations between COVID-19 and atrial fibrillation: A bidirectional Mendelian randomization studyResearch article Published on 2022-04-012022-10-05 Journal: Nutrition, metabolism, and cardiovascular diseases [Category] 유전자 메커니즘, [키워드] 95% CI 95% confidence interval addition Analysis association Atrial fibrillation attack bidirectional Bidirectional Mendelian randomization cardiovascular disease Causal coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection CVD directional pleiotropy Evidence General population hospitalized COVID-19 indicated mendelian randomization MR study MR-Egger observational study predicted progression provide risk severe COVID-19 severity significantly Support susceptibility [DOI] 10.1016/j.numecd.2021.11.010 [Article Type] Research article