Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trialClinical Trial Published on 2021-05-012022-10-05 Journal: Stem cells translational medicine [Category] SARS, 임상, 진단, [키워드] 1:1 24 hour acute respiratory distress AEs analyzed anti-inflammatory effect ARDS Cell cell transplantation cellular cellular therapy clinical trials Control control group COVID-19 cytokine death determine distress double-blind Effect Efficacy Endpoint event group groups high mortality immunomodulatory improved patient survival intention to treat intravenous infusion mesenchymal stem cell Mesenchymal stem cells patient survival Randomized Randomized controlled trial randomized, controlled trial respiratory tract SAEs Safe secondary Serious Adverse Event severity significantly Standard of care stem cell Stratification subject survival syndrome Time to recovery transplantation Treatment treatment group UC-MSC umbilical Umbilical cord was performed was used with COVID-19 [DOI] 10.1002/sctm.20-0472 PMC 바로가기 [Article Type] Clinical Trial
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cellsResearch Published on 2021-04-142022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression analyses analyzed Blot cell membranes COVID-19 demonstrated Donor donors expressed expression flow cytometry future therapeutic Host HUC-MSC human lung tissue immunofluorescence immunomodulatory effects immunomodulatory property implication low expression mesenchymal stem cell Mesenchymal stem cells novel coronavirus disease polymerase chain populations positive Protein qPCR Quantitative reported Result SARS-CoV-2 SARS-CoV2 significantly lower stem cell supplementary material TMPRSS2 TMPRSS2 expression treat umbilical viral infection was obtained [DOI] 10.1186/s12967-021-02813-6 PMC 바로가기 [Article Type] Research
Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Treatment of Viral DiseasesReview Published on 2021-04-012022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] activate antibody production Antigen antigen-presentation antiviral immune response B cells CD4+ CTLs cytokine cytotoxicity damage-associated molecular pattern Diseases elicit ENhance Factors Immune cell immunomodulation immunomodulatory immunoregulatory cytokine infected cell Inflammatory cytokine interferon knowledge macrophages mesenchymal stem cell Mesenchymal stem cells modulate molecular mechanism MSC MSCs NK cell Prevent promote regulate released responsible Secretome STEM stem cell T helper cell therapeutic potential therapy tissue repair tissues Treatment Viral diseases viral pathogens virus-infected cells viruses [DOI] 10.3390/pathogens10040409 PMC 바로가기 [Article Type] Review
Efficacy of the current investigational drugs for the treatment of COVID-19: a scoping reviewCOVID-19 치료를 위한 현재 연구 약물의 효능: 범위 검토Review Article Published on 2021-03-122022-08-31 Journal: Annals of Medicine [Category] 치료제, [키워드] anticoagulant therapies anticoagulant therapy Arbidol available data clinical recovery ClinicalTrials Cochrane Library conducted coronavirus Corticosteroids COVID-19 COVID-19 patients COVID-19 virus database databases drug drugs effective Efficacy eligibility criteria eligible Evidence Favipiravir Final ICTRP Immunoglobulin individuals initial interferon interferons Lopinavir Lopinavir-ritonavir mesenchymal stem cell no significant difference Plasma transfusion Pneumonia Prognosis promote Recovery time Ritonavir Sample size SARS-CoV-2 standard care stem cell Stem cell transplantation systematic literature search Tocilizumab Treatment treatment for COVID-19 treatment results treatments for COVID-19 treatments of COVID-19 Viral viral clearance virus [DOI] 10.1080/07853890.2021.1875500 PMC 바로가기 [Article Type] Review Article
Mesenchymal stem cell alongside exosomes as a novel cell-based therapy for COVID-19: A review studyReview Article Published on 2021-03-062023-07-01 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, [키워드] AAT, Alpha-1-anti trypsin ACE2, angiotensin-converting enzyme 2 ARDS, acute respiratory distress syndrome Coronavirus disease 2019 COVID-19, Coronavirus disease 2019 CXCL10, C-X-C motif chemokine ligand 10 DCs, dendritic cells Exosome HGF, Hepatocyte Growth Factor HLA, human leukocyte antigen IL-1RA, interleukin-1 receptor antagonist KGF, Keratinocyte growth factor MCP1, monocyte chemoattractant protein 1 MERS-CoV, Middle East respiratory syndrome coronavirus mesenchymal stem cell MIP1α, Macrophage inflammatory protein 1α MMP, matrix-metalloprotein MSC, mesenchymal stem cell RAS, The Renin-Angiotensin system SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 TGF, Transforming growth factor TMPRSS2, Transmembrane protease/serine2 TNF, Tumor Necrosis Factor Treatment VE, Vascular endothelial VGEF, Vascular endothelial growth factor [DOI] 10.1016/j.clim.2021.108712 PMC 바로가기 [Article Type] Review Article
Harnessing adipose‑derived stem cells to release specialized secretome for the treatment of hepatitis BArticle Published on 2021-03-012023-06-10 Journal: International journal of molecular medicine [Category] B형 간염, [키워드] adipose‑derived stem cell Hepatitis B virus hepatitis BX antigen mesenchymal stem cell Secretome [DOI] 10.3892/ijmm.2021.4848 PMC 바로가기
Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 PatientsCell and Developmental Biology Published on 2021-02-052022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα [DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology
Cell-Based Therapy for Severe COVID-19 Patients: Clinical Trials and Cost-Utility중증 COVID-19 환자를 위한 세포 기반 치료: 임상 시험 및 비용 활용Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] SARS, 임상, [키워드] Abstract acute respiratory distress acute respiratory distress syndrome antigen recognition approach approved Cell Cell therapy Cell-based therapy cellular clinical clinical study clinical trial clinical trials cost country COVID-19 decrease dendritic cells develop Exosome Exosomes Government immune response immune system Immunotherapy infected cells Inflammatory introduced mesenchymal stem cell Mesenchymal stem cells moderate moderate to severe MSC MSCs natural outcomes pandemic promote regulate respiratory distress resulting stem cell stimulate syndrome T cell T cells Therapeutics therapy treating COVID-19 treating COVID-19 patient Treatment Trial Vaccine Viral viral disease Viral diseases viral infections virus-infected cell virus-infected cells [DOI] 10.1007/s12015-020-10046-1 PMC 바로가기 [Article Type] Review
Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension안지오텐신 전환 효소 2의 대사 링커로서의 생리학적 관련성 및 COVID-19 및 고혈압에서 중간엽 줄기 세포의 치료적 의미Review Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome age aldosterone angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antihypertensive therapy approach approved Asymptomatic carried Cell clinical trial combating Combination Comorbidity conducted Consequences conserved contribute contributed Corona virus Coronavirus-2 COVID-19 COVID-19 infections Critically ill cytokine Cytokine storm death diabetes Diabetes Mellitus Efficacy enzyme Evidence expressed help Host host cell hypertension immunomodulatory individual infecting inhibitor Interaction involved lead many case many cases mechanism medical condition mesenchymal stem cell metabolic molecular multi organ outcome pharmacological positive priming Prognosis protease protocol receptor regenerative properties Relevance Renin Renin-angiotensin-aldosterone-system reported residue respiratory responsible RNA virus SARS-CoV-2 Serine Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus spike Spike protein standard treatment STEM stem cell Stem cell transplantation surface protein Symptom TMPRSS2 transmembrane Transmembrane protease serine-2, Mesenchymal Stem Cell. Viral viral spike protein virus [DOI] 10.1007/s12015-020-10012-x PMC 바로가기 [Article Type] Review
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case seriesCOVID-19로 유발된 중증 ARDS 환자 치료를 위한 주산기 조직 유래 중간엽 줄기세포: 사례 시리즈Clinical Trial Published on 2021-01-292022-08-13 Journal: Stem Cell Research & Therapy [Category] 바이오마커, 임상, 진단, [키워드] acute renal and hepatic failure acute respiratory distress syndrome age Allogeneic allogeneic prenatal Alpha ARDS ARDS patients C-reactive protein C-reactive protein (CRP candidate Cardiac arrest Cardiomyopathy case sery cell infusion cell infusions Cell therapy cells chronic lymphocytic leukemia clinical trial CLL CMP Comorbidities Comorbidity Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill develop diabetes diagnosed died discharged distress Dyspnea eight enrolled fatal complication feasibility finding FIVE hepatic failure High dose hospital human umbilical cord MSCs hypertension Hypoxemia ICU ICUs IFN-γ IL-6 IL-6 level IL-6 levels IL-8 IMPROVE Inflammatory biomarker inflammatory biomarkers infusion intensive care unit intensive care units interferon gamma intravenous infusion Large randomized multicenter clinical trials leukemia Leukocytosis lung lymphocyte Lymphocytes mechanical ventilation men mesenchymal stem cell Mesenchymal stem cells Mesenchymal stromal cells MSC MSCs multi-organ failure multicenter one patient outcome Patient patients perinatal tissue Phase 1 PL-MSCs Placenta placental MSC placental MSCs Pneumonia Potential treatment Radiological parameter Radiological parameters Randomized reduce reduced renal reported required respiratory distress Respiratory distress syndrome Safe Sepsis Serious Adverse Event Serious Adverse Events Serum level serum levels Seven severe hypoxemia Significant reduction significant reductions SpO2 stem cell Stem cell therapy supplementary material survivor Survivors syndrome the cell therapeutic potential TNF-α Tolerability Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha UC-MSCs umbilical Umbilical cord women [DOI] 10.1186/s13287-021-02165-4 PMC 바로가기 [Article Type] Clinical Trial