Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19COVID-19에 비해 다기관 염증 증후군 아동에서 SARS-CoV-2-특이 T 세포 반응의 제한된 유도Research Article Published on 2022-02-222022-09-10 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Adaptive immunity B cell responses CD4 CD8 Cellular immune response children contribute convalescent COVID-19 cytokine cytokine production cytokine response demonstrated develop full-length functional healthy controls Inflammatory Limited MIS-C mononuclear cell mononuclear cells nucleocapsid participant Pathogenesis peptides Peripheral blood Peripheral blood mononuclear cells plasma predominant quantified RBD Receptor binding domain responses against SARS-CoV-2 antigen SARS-COV-2 infection serologic Serologic response serologic responses significantly lower Spike receptor binding domain subset Support syndrome T cell T cell response T cell responses T cells Th1 Viral Viral proteins was reduced with COVID-19 [DOI] 10.1172/jci.insight.155145 PMC 바로가기 [Article Type] Research Article
Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19Research Published on 2022-02-172022-10-31 Journal: Genome Medicine [Category] COVID-19, MERS, [키워드] ABO airways alteration association calculate CCR1 CD8+ T cell CD8+T cell Cell cell types Cell-mediated immunity cells chemotaxis collected contribute Control COVID-19 COVID-19 infection COVID-19 pandemic CXCR6 cytokine detrimental disease severity dysregulated immune response Effect effective vaccine elevated epithelial cell expressed expressed gene expression facilitate Factor feature functional Genes Genetic genetic architecture genetic determinant GWAS GWAS summary statistics healthy control higher risk Host host genetics IFITM1 Immune cell immune cells immune response Immunity immunological increase in independent Inflammatory Inflammatory cytokines inflammatory storm Interaction involved lung tissues memory Migration Mild moderate mononuclear cell notable Patient PBMC Peripheral blood progression proliferation provide recruitment Result reveal risk S100A12 S100A8 S100A9 scRNA-seq dataset sequencing data severe COVID-19 Severe infection Severe patient severe patients severity of COVID-19 significantly single-cell single-cell sequencing subpopulation subset subtype supplementary material Symptom T cell understanding up-regulated [DOI] 10.1186/s13073-022-01021-1 PMC 바로가기 [Article Type] Research
T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of ConcernBrief Report Published on 2022-02-082022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] addition Administered affected antigenic drift B.1.1.529 BNT162b2 carried Cell cells collected comparable concern COVID-19 COVID-19 pandemic dominant Efficacy eight ELISPOT examined fluorescent FluoroSpot form healthy volunteer IL-10 IL-4 Immunity individuals Maintained manifested mononuclear cell omicron overlapping PBMC peptide Peripheral blood progression Protective protective immunity reactivity reduced representing response SARS-CoV-2 SARS-CoV-2 virus variants secreting severe disease manifestations significantly Spike protein stimulated T cell T cell response T cell responses tested Th1 response the SARS-CoV-2 vaccination Vaccines variant variants of concern VoC wild-type Wuhan-1 [DOI] 10.3390/v14020347 PMC 바로가기 [Article Type] Brief Report
SARS-CoV-2 antibody and T cell responses one year after COVID-19 and the booster effect of vaccination: A prospective cohort study코로나19 1년 후 SARS-CoV-2 항체 및 T 세포 반응과 백신 접종의 부스터 효과: 전향적 코호트 연구Article Published on 2022-02-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Ad26 Ad26.COV2-S Anti-RBD IgG antibody Antibody Response Blood BNT162b2 booster ChAdOx1 ChAdOx1-S comparable Concentration COVID-19 COVID-19 vaccination COVID-19 vaccine detectable first vaccination healthcare worker Healthcare workers IgG IgG response IgG responses immune response immune responses Immunity Immunoglobulin Immunoglobulin G individual individuals infected individuals IQR Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 mononuclear cell mononuclear cells mRNA mRNA-1273 PBMCs Peripheral blood Peripheral blood mononuclear cells prospective cohort prospective cohort study RBD IgG response retained SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection second second vaccination seroconverted spot-forming cell suffered T cell T cell response T cell responses vaccination vaccine-induced immune response vaccine-induced immune responses [DOI] 10.1016/j.jinf.2021.12.003 PMC 바로가기 [Article Type] Article
Development of an in-house SARS-CoV-2 interferon-gamma ELISpot and plate reader-free spot detection method자체 SARS-CoV-2 인터페론 감마 ELISpot 및 플레이트 리더 프리 스팟 검출 방법 개발Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antigen antigens automated Concentration convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic demonstrated detect development diagnostic effective elicited ELISPOT enzyme enzyme-linked immunospot IFN-γ Immunity Infection Interferon-gamma mononuclear cell mononuclear cells multiple antigen Neutralising Antibodies peptide Peripheral blood Peripheral blood mononuclear cells plate reader quantified reliability Research respiratory response SARS-CoV-2 SARS-CoV-2-specific T cells severe acute respiratory syndrome Coronavirus stimulate T cell T cell response T cell responses T cells vaccination Volunteer volunteers [DOI] 10.1016/j.jviromet.2021.114398 PMC 바로가기 [Article Type] Article
Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다Immunology Published on 2022-01-282022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection [DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology
Effect of Fucoidan on the Mitochondrial Membrane Potential (ΔΨm) of Leukocytes from Patients with Active COVID-19 and Subjects That Recovered from SARS-CoV-2 InfectionArticle Published on 2022-01-242022-10-30 Journal: Marine Drugs [Category] COVID-19, SARS, [키워드] addition Anti-inflammatory Anti-viral cationic CCCP cellular homeostasis complementary COVID-19 COVID-19 patient determine Effect evaluated fucoidan healthy control healthy subject induce Infection mitochondrial membrane potential mononuclear cell PBMC Peripheral blood polysaccharide Potential Potential treatment promote recovered SARS-CoV-2 SARS-COV-2 infection subject subjects therapeutic target therapy Treatment [DOI] 10.3390/md20020099 PMC 바로가기 [Article Type] Article
The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapyMITER 시험 프로토콜 : 면역 체크 포인트 억제제 요법을받는 암 환자에서 효능 및 독성의 바이오 마커로서 미생물 군집을 평가하는 연구Study Protocol Published on 2022-01-242022-09-10 Journal: BMC Cancer [Category] 비임상, [키워드] advanced disease adverse event antibody Antigen association Bacterial Biomarker Biomarkers biopsy breath buffy coat Cancer cancer patient Cell collected correlation COVID-19 CTCAE disease Disease progression drug during treatment Efficacy evaluate Exploratory analyses genomic Gut gut microbiome help identify immune Immune checkpoint inhibitor Immune checkpoint inhibitors immunological Immunotherapy implicated IMPROVE include information inhibitor limit longitudinal lung cancer patient marker Melanoma microbial Microbiome mononuclear cell mononuclear cells mouse model non-responder Non-small cell lung cancer observation organ outcome outcomes Patient patient selection PBMCs Peripheral blood Peripheral blood mononuclear cells plasma predict Predictive primary outcome measure Prospective Study receive receiving recruited recurrence Registered Relapse renal Renal cancer responders responsible RNA secondary Secondary outcomes Stool supplementary material survival therapeutic therapeutic potential therapy tissue Toxicity transfer Treatment Treatment response Trial Whole blood [DOI] 10.1186/s12885-021-09156-x PMC 바로가기 [Article Type] Study Protocol
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과Research Article Published on 2022-01-212022-09-10 Journal: eLife [Category] 변종, [키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured [DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article
Transmitted Fetal Immune Response in Cases of SARS-CoV-2 Infections during PregnancyArticle Published on 2022-01-192022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] age analyzed anti-SARS-CoV-2 antibodies CD3 CD3+ CD34 CD4 CD8 cell count cellular immunity change Concentration concentrations correlation COVID-19 and pregnancy diagnosis of SARS-CoV-2 Effect fetal fetal immune system fetal lymphocyte subsets humoral IFN-γ IgG IgG and IgM IgM antibody IL6 immune response Immunity Infection Inflammatory response information iNKT interleukin interleukin 6 mononuclear cell Newborn Placenta placental Placentas Pregnancy pregnant women recruited Research response RNA SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection significantly higher study period subset T cell the SARS-CoV-2 virus transfer transmitted umbilical cord blood undetectable Viral RNA [DOI] 10.3390/diagnostics12020245 PMC 바로가기 [Article Type] Article