myeloid cells – Page 6 – Communicable Diseases Research

Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19

COVID-19의 심각한 진행과 관련된 염증 및 항바이러스 면역 반응

Clinical Trial

Published on 2021-02-182022-08-13
Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 신종인플루엔자, 유전자 메커니즘, 임상,

VISTA: A Target to Manage the Innate Cytokine Storm

VISTA: 타고난 사이토카인 폭풍을 관리하기 위한 표적

Review

Published on 2021-02-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단,

[키워드] agonistic antibodies Anti-inflammatory Antigen presentation Autoimmune diseases blockade Cancer canonical marker canonical markers CD14 CD16 Cell change Complete conserved COVID-19 cytokine Cytokine storm Cytokine storms Diseases driven by dysregulated immune response expression Fcγr3a focus highlight human monocyte human monocytes Hyperinflammatory response IFN-I immune immune checkpoint immune responses immune system Immunity Immunosuppression Immunotherapy implication Inflammatory responses inhibitory Innate monocyte reprogramming Monocytes myeloid myeloid cell myeloid cells offer pathogenic pathology pathway Pathways phenotype receptor related diseases storm Support suppress T cell T cell activation target the interferon therapeutic triggering unique Viral viral infection viral infections vista while
[DOI] 10.3389/fimmu.2020.595950 PMC 바로가기 [Article Type] Review

Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis

Article

Published on 2021-01-012023-06-10
Journal: Developmental and comparative immunology [Category] 원숭이두창,

[키워드] epigenetics histone deacetylase myeloid cells Tissue and organ regeneration Xenopus laevis tail.
[DOI] 10.1016/j.dci.2020.103840

No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19

COVID-19에 대한 암 및 전염병 관련 FPR1 다형성의 영향 없음

Multicenter Study

Published on 2020-12-082022-09-11
Journal: Oncoimmunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] accelerate Affect allelic anticancer Antigen presentation Bacterial Cancer coding coronavirus coronavirus disease Coronavirus disease-19 COVID-19 danger-associated molecular pattern defect dendritic cells detect Effect fibrosis formyl FPR1 Frequency hospital Hypothesis immune responses Immunogenetics innate immune response innate immune responses investigated involved Lung inflammation manifestation myeloid cells nucleotide Paris pathogen pathogen-associated molecular pathogen-associated molecular patterns Patient peptide plague polymorphism receptor reduced reported SARS-CoV-2 secondary to severity severity of COVID-19 single nucleotide Single nucleotide polymorphism Trigger Yersinia Yersinia pestis
[DOI] 10.1080/2162402X.2020.1857112 PMC 바로가기 [Article Type] Multicenter Study

Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era

Article

Published on 2020-11-062023-08-29
Journal: Brain pathology (Zurich, Switzerland) [Category] E형 간염,

[키워드] MS myeloid cells Neuroinflammation sc‐RNA‐Seq
[DOI] 10.1111/bpa.12910 PMC 바로가기

Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19

Article

Published on 2020-10-292022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

[키워드] activated Algorithm Analysis APOC1 ApoE BAL BCL2A1 Bronchoalveolar lavage Bronchoalveolar lavage (BAL) C1QB canonical category CCL2 CCL3 CCL5 CCL8 CCR1 Cell cellular chemotactic chemotaxis circulation Clustering Cohort complex coronavirus disease correlation COVID-19 CXCL8 Cytokine storm dataset diagnostic disease severity downregulated EPSTI1 FABP4 FIVE FPR1 functional gene signature gene signatures hallmark healthy subject healthy subjects ICGS2 identify IFI27 IFI30 Ifi44 IFI44L IFI6 IFIT1 IFIT3 IFITM1 IFITM2 IFITM3 IFNg IL17 IL1A IL1B IL1RN immune Immune cell Inflammatory inflammatory macrophages Inflammatory response interstitial iterative KLF6 Macrophage MALAT1 Mild mononuclear cell MX1 myeloid cells NEAT1 neutrophil Neutrophils NFkB OAS1 OAS2 OAS3 OASL pathway Patient patients PBMCs Peripheral blood phagocytes phagocytosis PLSCR1 PRL reduction reflected role S100A8 SARS-CoV-2 SAT1 several gene severe COVID-19 severity Signaling Single Cell SPP1 STAT3 subset suppressed systemically TGM2 therapeutic interventions TLR7 TLR9 TNF TYMP UMAP upstream with COVID-19
[DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Research

Published on 2020-07-292022-10-05
Journal: Nature [Category] SARS, 치료기술, 치료법,

[키워드] activating Activation acute lung injury acute respiratory distress acute respiratory syndrome Analysis assessment blockade Blood Bronchoalveolar lavage fluid C5a caused complement coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity damaged disease Factor high expression level Immune cell immune responses Infection infiltration Inflammation Inflammatory response inhibited limit longitudinal analysis Lung inflammation mice monoclonal antibody myeloid cell myeloid cells neutrophil organ pathophysiology Patient patients with COVID-19 phenotypic Pneumonia Prevent prevented proportion receptor recruitment SARS-CoV-2 severity of COVID-19 Stage Support syndrome therapeutic
[DOI] 10.1038/s41586-020-2600-6 [Article Type] Research

Role of Autophagy in Lung Inflammation

Immunology

Published on 2020-07-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] accompanied activated antigen presenting cell approach Asthma asthmatic autophagic autophagic flux autophagy caused Cell cell type cells cellular cellular homeostasis changes in characterized complicate COVID-19 decrease develop disease dysfunction Effects eukaryotic functions granulocyte human cell Immune cell immunometabolism Impaired implicated implication Inflammasome Inflammation inflammatory disease Lineage lung Lung inflammation lymphoid lymphoid cell lysosome metabolism modulation myeloid cells non-immune Organisms Pathogenesis pathology phenotype Population populations Protein role SARS-CoV-2 shown specificity survival Symptoms tissue remodeling Treatment variety viral pathogenesis worse prognosis
[DOI] 10.3389/fimmu.2020.01337 PMC 바로가기 [Article Type] Immunology

The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

Review

Published on 2020-06-102023-06-20
Journal: Cell Host & Microbe [Category] Fulltext, MERS,

[키워드] complement COVID-19 Cytokines innate immune response myeloid cells Natural killer cells SARS-CoV-2
[DOI] 10.1016/j.chom.2020.05.009 PMC 바로가기 [Article Type] Review

Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease

자가 반응성 T 세포 및 자가면역 질환의 방관자 활성화에 대한 새로운 조절자로서의 Clec4b의 확인

Research Article

Published on 2020-06-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence Activation Antigen antigen-presenting cell antigen-presenting cells Arthritis Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity autoreactive T cell autoreactive T cells avoidance bystander CD11b CD4 CD4+ Cell chronic inflammation classical Clinical diagnosis complex Control control mechanism Critical DCs defined dendritic cell dendritic cells dependent on disease early disease expansion expressed expression followed by Genetic identification identify immune regulation immune response immune-priming in vitro in vivo injection limit loss of function marker mechanism MHCII myeloid cells nucleotide pathogenic pathway polymorphism receptor recombinant recombinants regulate Regulatory reveal rheumatoid arthritis shown single nucleotide Single nucleotide polymorphism Strains T cell T cells turn
[DOI] 10.1371/journal.pgen.1008788 PMC 바로가기 [Article Type] Research Article