Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variantsSARS-CoV-2 스파이크 단백질 유전자 변이체의 출현 및 지리적 분포를 감지하기 위한 동반 생물정보학 도구의 설계Research Published on 2020-12-302022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis antibody B-cell epitope Bioinformatic workflow consensus sequence coronavirus COVID mutations dataset detect disease severity Docker epitope Evolution framework generate Genetic genetic variability Genetic variant Genomic variability geographical distribution GISAID identify MHC mine mutated Mutation Neutralizing neutralizing monoclonal antibodies online tool Phylogenetic analysis portal Probability Protein protocol provide RBD Receptor binding domain receptor binding motif reduced released respiratory Result reveal robust S477N SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 vaccine sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single mutation single mutations spike Spike protein Spike protein receptor binding domain T-cell the Spike Vaccine Vaccine design variant variants Variation variations Viral writing [DOI] 10.1186/s12967-020-02675-4 PMC 바로가기 [Article Type] Research
SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe diseaseLetter Published on 2020-09-252022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] antibodies binding antibody Antibody neutralization determinant Immunity implication Isolation Live virus neutralization neutralizing monoclonal antibodies Non-severe Patient patients plasma plasma antibody response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 pseudovirus severe severe disease significantly higher Spike protein the viral nucleocapsid therapy titer [DOI] 10.1080/22221751.2020.1823890 PMC 바로가기 [Article Type] Letter
Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus InfectionReview Published on 2018-11-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] approved Combination distribution domain effective Epitopes Fatality rate global public health Immunotherapy mAb mAbs MERS MERS-CoV MERS-CoV infection Middle East Middle East Respiratory Syndrome Virus mutant Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody Passive Prophylactic RBD respiratory selective the spike protein therapeutic therapeutic agent Therapeutics therapy Vaccine viruses [DOI] 10.3390/v10120680 PMC 바로가기 [Article Type] Review
A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoVArticle Published on 2018-08-232022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antiviral agent Antiviral agents authentic virus biosafety BSL-3 cause Dipeptidyl peptidase 4 expression hDPP4 high mortality rate Human Infection inhibitor locus m336 MERS-CoV mice Middle East mouse model neutralizing monoclonal antibodies Pathogenesis peptide pseudotyped Pseudotyped virus pulmonary disease Respiratory illness respiratory syndrome coronavirus resulting susceptible transgene virus [DOI] 10.3390/v10090448 PMC 바로가기 [Article Type] Article
Humanized antibody neutralizing 2009 pandemic H1N1 virusArticle Published on 2014-12-012023-06-25 Journal: Biotechnology Journal [Category] 신종인플루엔자, [키워드] 2009 pandemic H1N1 Antibody humanization CDR grafting epitope mapping neutralizing monoclonal antibodies [DOI] 10.1002/biot.201400083